BREAST CYTOPATHOLOGY

Figure 5.6. Metastatic small cell carcinoma of the lung. Hypercellular
smear illustrating the characteristic neuroendocrine cytomorphology,
that is, small round oval nuclei, fine dusty chromatin, nuclear
molding, nuclear crush artifacts, and numerous karyorrhectic nuclei.
Distinction from a primary neuroendocrine carcinoma of the breast
is not possible on morphology alone. (Smear, Papanicolaou.)
Figure 5.7. Metastatic small cell carcinoma of the uterine cervix.
This patient in advanced clinical stage presented with a breast mass.
Cytomorphology as seen here looks concordant with a primary cervical
tumor. The smear is hypercellular with large nests of neuroendocrine
cells, depicting high-grade morphology. Note prominent
nuclear molding, lack of cytoplasm, and abundant karyorrhexis.
(Smear, Diff-Quik.)