BREAST CYTOPATHOLOGY

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116 4. Primary Malignant TumorsPitfalls and Differential Diagnosis• Invasive ductal carcinoma NOSSecretory CarcinomaClinical Features• First reported in children and called juvenile carcinoma• Occurs in children, adolescents, and adults• Occurs in both men and women• Shows a tubuloalveolar pattern of growthCytomorphologic Characteristics• Hypercellular smears• Background mucinous material• Cells with abundant cytoplasm and intracytoplasmic vacuoles• “Globules” of secretory materialPitfalls and Differential Diagnosis• Fibrocystic changes, papillomatosis• Lactational changesAdenoid Cystic CarcinomaClinical Features• Rare tumors with good prognosis• Slowly enlarging breast mass• Lobulated and well-defined by mammographyCytomorphologic Characteristics (Figures 4.38 and 4.39)• Smears with globules and/or cylinders of pale blue hyalinematerial on Papanicolaou stain• Bright magenta globules on Diff-Quik stain• Small hyperchromatic cells with very little cytoplasmsurrounding the globules• Inconspicuous nucleoli
Special Types of Breast Carcinomas 117Figure 4.38. Adenoid cystic carcinoma. A large fragment of basaloid-typeepithelium containing well-defined magenta-coloredhyaline globules. (Smear, Diff-Quik.)Figure 4.39. Adenoid cystic carcinoma. The aspirate harvested twolarge fragments of carcinoma consisting of tightly arranged uniformbasaloid cells. A large refractile globule is evident in the fragmentat 7 o’clock. (Smear, Papanicolaou.)
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Breast Cytopathology
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Syed Z. Ali, MDDepartment of Pathol
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To my parentsGul Bano (late) and Ma
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viiiForewordthis volume to rejuvena
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xSeries Prefaceand form the framewo
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xiiPrefacecarefully selected high-r
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ContentsForeword by Dorothy L. Rose
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2 1. Introduction and Technical Asp
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10 1. Introduction and Technical As
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2Non-neoplastic andProliferative Le
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18 2. Non-neoplastic and Proliferat
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Figure 2.26. Lactational change. Hy
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58 3. Benign and Borderline TumorsC
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60 3. Benign and Borderline TumorsF
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Page 152 and 153: 5Metastatic and SecondaryTumorsMeta
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166 IndexApocrine carcinomain axill
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168 IndexDuctal carcinoma (cont.)fi
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170 IndexFine-needle aspiration, of
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172 IndexLung cancer, 138metastatic
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174 IndexPapilloma (cont.)invasive
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BREAST CYTOPATHOLOGY

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