BREAST CYTOPATHOLOGY

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112 4. Primary Malignant TumorsFigure 4.31. Tubular carcinoma. This composite image showsa pathognomonic feature of the tumor, that is, formation of arigid tubular architecture (“hose pipe–like”). Also notice thecharacteristic right angle branching of the tubules. (Smear,Papanicolaou.)Figure 4.32. Tubular carcinoma. Higher magnification of the tubulararchitecture. The carcinoma cells are uniform and appear low grade.Noticeable features include a rigid architecture with parallel wallsand open lumen at the end. (Smear, Papanicolaou.)
Special Types of Breast Carcinomas 113Figure 4.33. Tubular carcinoma. The tumor consists of small, round,uniform nuclei arranged in tubules with open lumens and prominentscalloping (noted at 6 o’clock). (Smear, Papanicolaou.)• More common in younger patients• Presents as a solitary, soft, well-circumscribed, and mobilemass• Clinically mimics fibroadenoma, benign cyst, or an intramammarylymph node• Much better prognosis, even with axillary node metastasisCytomorphologic Characteristics (Figures 4.34 to 4.37)• Hypercellular smears• Relatively larger, pleomorphic cells, single or in loose clusters,often syncytial arrangements• Large nuclei with large nucleoli• Naked nuclei with macronucleoli, better appreciated onDiff-Quik stain• Background lymphocytes, often in close proximity to cellularsyncytia• Cellular degeneration and/or necrosis
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Breast Cytopathology
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Syed Z. Ali, MDDepartment of Pathol
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To my parentsGul Bano (late) and Ma
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viiiForewordthis volume to rejuvena
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xSeries Prefaceand form the framewo
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xiiPrefacecarefully selected high-r
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ContentsForeword by Dorothy L. Rose
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2 1. Introduction and Technical Asp
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10 1. Introduction and Technical As
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2Non-neoplastic andProliferative Le
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18 2. Non-neoplastic and Proliferat
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Figure 2.26. Lactational change. Hy
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58 3. Benign and Borderline TumorsC
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60 3. Benign and Borderline TumorsF
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Page 100 and 101: 86 4. Primary Malignant Tumors• M
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Page 152 and 153: 5Metastatic and SecondaryTumorsMeta
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Page 160 and 161: BFigure 5.9. (B) Metastatic papilla
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Page 170 and 171: 156 6. Breast Ductal LavageFigure 6
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162 6. Breast Ductal Lavagecarcinom
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164 6. Breast Ductal LavageKrishnam
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166 IndexApocrine carcinomain axill
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168 IndexDuctal carcinoma (cont.)fi
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170 IndexFine-needle aspiration, of
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172 IndexLung cancer, 138metastatic
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174 IndexPapilloma (cont.)invasive
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BREAST CYTOPATHOLOGY

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