BREAST CYTOPATHOLOGY

• Colloid carcinoma
• Fibroadenoma
Lipid-Rich Carcinoma
Clinical Features
• Lipid-rich carcinoma is an extremely rare variant (1%) of
invasive breast carcinoma, characterized by the presence
of abundant cytoplasmic neutral lipids in the majority of
neoplastic cells of the tumor.
• The patient age range is wide, from 33 to 81 years.
• Most patients present with palpable masses.
• The reported tumor sizes have ranged from 1.2 to
15 cm.
• In a series of 13 cases, described by Ramos et al. in 1974,
11 patients had extensive lymph node metastasis.
Cytomorphologic Characteristics
• Most cases show invasive carcinoma with neoplastic cells
with large, foamy, vacuolated cytoplasm.
• The droplets within the cytoplasm contain neutral lipids.
Pitfalls and Differential Diagnosis
• Secretory carcinoma
• Glycogen-rich carcinoma
• Apocrine carcinoma
Colloid (Mucinous) Carcinoma
Special Types of Breast Carcinomas 107
Clinical Features
• More common in the postmenopausal age group
• Distinctly better prognosis
• Rarely metastasizes, but often local recurrences occur
• Less nodal involvement than in infiltrating ductal carcinoma
NOS
• Often present as a large slowly growing mass, soft and well
circumscribed on palpation