BREAST CYTOPATHOLOGY

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92 4. Primary Malignant TumorsHistologic FeaturesHistologically, infiltrating duct cell carcinoma is characterizedby a spectrum of changes that vary according to the atypiaand differentiation, such as the degree of tubule formation,nuclear pleomorphism, and mitotic activity. Cytologically,variable patterns reflecting the diverse histologic morphologyof the tumors are seen. Breast aspirates of infiltrating ductcell carcinoma are cellular and often show conspicuous lossof cell cohesion.Cytomorphologic Characteristics (Figures 4.10 to 4.17)• Variably cellular• Fragments and singly dispersed malignant cells• Often a prominent plasmacytoid cellular appearance• Occasionally, pleomorphism, hyperchromasia, mitosis,necrosis, and a background of tumor diathesisFigure 4.10. Ductal carcinoma. Irregular fragments of carcinomawith enlarged, hyperchromatic nuclei. A few single malignant cellsare noted as well. A follow-up biopsy revealed an infiltrating ductalcarcinoma. (Smear, Diff-Quik.)
Ductal Carcinoma 93Figure 4.11. Ductal carcinoma and atypical ductal hyperplasia.Compare and contrast cytomorphologic characteristics of these twoentities. Infiltrating ductal carcinoma (right) shows greater pleomorphism,a significantly large nuclear size, more cellular dissociation,and prominent eccentric placement of the nucleus than atypicalductal hyperplasia (left). (Smear, Papanicolaou.)Figure 4-12. Ductal carcinoma. Higher magnification of the tumorwith overt malignant characteristics, that is, dissociated cells, markednuclear enlargement, nuclear hyperchromasia, and a totally disorganizedarchitecture. A follow-up biopsy revealed an infiltrating ductalcarcinoma. (Smear, Diff-Quik.)
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Breast Cytopathology
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Syed Z. Ali, MDDepartment of Pathol
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To my parentsGul Bano (late) and Ma
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viiiForewordthis volume to rejuvena
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xSeries Prefaceand form the framewo
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xiiPrefacecarefully selected high-r
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ContentsForeword by Dorothy L. Rose
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2 1. Introduction and Technical Asp
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10 1. Introduction and Technical As
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2Non-neoplastic andProliferative Le
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18 2. Non-neoplastic and Proliferat
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Page 100 and 101: 86 4. Primary Malignant Tumors• M
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Page 152 and 153: 5Metastatic and SecondaryTumorsMeta
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142 5. Metastatic and Secondary Tum
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Figure 5.6. Metastatic small cell c
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BFigure 5.9. (B) Metastatic papilla
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154 6. Breast Ductal LavageTable 6.
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156 6. Breast Ductal LavageFigure 6
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162 6. Breast Ductal Lavagecarcinom
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164 6. Breast Ductal LavageKrishnam
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166 IndexApocrine carcinomain axill
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168 IndexDuctal carcinoma (cont.)fi
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170 IndexFine-needle aspiration, of
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172 IndexLung cancer, 138metastatic
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174 IndexPapilloma (cont.)invasive
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BREAST CYTOPATHOLOGY

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