National Cancer Institute - NCI Division of Cancer Treatment and ...
National Cancer Institute - NCI Division of Cancer Treatment and ... National Cancer Institute - NCI Division of Cancer Treatment and ...
CANCER THERAPY EVALUATION PROGRAM The Cancer Therapy Evaluation Program fosters collaborations within the cancer clinical research community and works extensively with the pharmaceutical and biotechnology industries. The death rate from all cancers combined has been decreasing in the United States since 1991, and since 2003 the decrease has been large enough to outpace the growth and aging of the population, reducing the actual number of cancer deaths—a remarkable turn in the decades-long fight against cancer. This milestone has been achieved, in part, because therapeutic and preventive interventions to fight cancer are working. One key to the success of these interventions is that they were tested rigorously in the clinic. Clinical trials are the mechanism for testing new approaches for cancer prevention, diagnosis, and treatment. More than 1500 NCI-sponsored clinical trials are conducted annually, and some 900 treatment trials are sponsored by the Cancer Therapy Evaluation Program (CTEP) within the Division of Cancer Treatment and Diagnosis (DCTD). CTEP is organized into nine offices and branches: ■ Office of the Associate Director ■ Clinical Grants and Contracts Branch ■ Clinical Investigations Branch ■ Clinical Trials Monitoring Branch O V E R V I E W ■ Investigational Drug Branch ■ Pharmaceutical Management Branch ■ Protocol and Information Office ■ Regulatory Affairs Branch ■ Office of AIDS Malignancy Program Not only does CTEP identify promising agents for evaluation, but also it identifies biomolecular characteristics of malignant Dr. Michaele C. Christian, Associate Director Michaele Chamblee Christian, M.D., was appointed Associate Director of the Cancer Therapy Evaluation Program of DCTD in 1997. She previously worked in the Investigational Drug Branch overseeing the clinical development of novel anticancer drugs. In 1995, she established NCI’s Clinical Trials Monitoring Branch, which oversees quality assurance and compliance for hundreds of NCI clinical trials. Dr. Christian received her M.D. from Georgetown University School of Medicine, graduating summa cum laude. Additionally, she completed residency training in internal medicine and fellowships in hematology and oncology at Georgetown. Among numerous awards, Dr. Christian received the Kober Award for highest academic achievement and was elected to Alpha Omega Alpha medical honor society. Her research interests include early therapeutics development, ovarian cancer treatment, clinical trial design, and enhancing participation of under- represented populations in clinical trials. Dr. Christian is often asked to speak about new opportunities in clinical research, including accelerating bench to bedside or practical translational research, using clinical trials networks to address broader transdisciplinary research questions, and the growing use of international collaborations to conduct research that addresses global medical needs. C A N C E R T H E R A P Y E V A L U A T I O N P R O G R A M ■ 65
Not only does CTEP identify promising agents for evaluation, but also it identifies biomolecular characteristics of malignant tumors that investigators may be able to exploit clinically. 66 ■ P R O G R A M A C C O M P L I S H M E N T S 2 0 0 6 ■ ■ ■ CTEP houses NCI’s primary program for evaluating new anticancer treatments. It also provides and tracks experimental agents for clinical trials run by other NCI components. During fiscal year 2005, CTEP: ■ Managed 942 active clinical trials ■ Supervised 127 active Investigational New Drugs (INDs) ■ Oversaw the recruitment of nearly 31,000 patients to CTEPsponsored clinical trials tumors that investigators may be able to exploit clinically. CTEP accomplishes its goals by administering, coordinating, and funding clinical trials, as well as sponsoring other clinical research. The program fosters collaborations within the cancer research community and works extensively with the pharmaceutical and biotechnology industries. CTEP also reaches out to patients and advocates to help establish research priorities. The program administered 399 grants in 2005 and played a role in 942 open clinical trials. NCI Visuals Online.
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Not only does CTEP identify promising agents for evaluation,<br />
but also it identifies biomolecular characteristics <strong>of</strong> malignant<br />
tumors that investigators may be able to exploit clinically.<br />
66 ■ P R O G R A M A C C O M P L I S H M E N T S 2 0 0 6<br />
■ ■ ■<br />
CTEP houses <strong>NCI</strong>’s primary program<br />
for evaluating new anticancer<br />
treatments. It also provides <strong>and</strong><br />
tracks experimental agents for clinical<br />
trials run by other <strong>NCI</strong> components.<br />
During fiscal year 2005, CTEP:<br />
■ Managed 942 active clinical trials<br />
■ Supervised 127 active Investigational<br />
New Drugs (INDs)<br />
■ Oversaw the recruitment <strong>of</strong><br />
nearly 31,000 patients to CTEPsponsored<br />
clinical trials<br />
tumors that investigators may be able to<br />
exploit clinically. CTEP accomplishes its<br />
goals by administering, coordinating, <strong>and</strong><br />
funding clinical trials, as well as sponsoring<br />
other clinical research. The program fosters<br />
collaborations within the cancer research<br />
community <strong>and</strong> works extensively with<br />
the pharmaceutical <strong>and</strong> biotechnology<br />
industries. CTEP also reaches out to<br />
patients <strong>and</strong> advocates to help establish<br />
research priorities. The program administered<br />
399 grants in 2005 <strong>and</strong> played a role<br />
in 942 open clinical trials.<br />
<strong>NCI</strong> Visuals Online.