National Cancer Institute - NCI Division of Cancer Treatment and ...
National Cancer Institute - NCI Division of Cancer Treatment and ... National Cancer Institute - NCI Division of Cancer Treatment and ...
DIVISION OF CANCER TREATMENT AND DIAGNOSIS The Division of Cancer Treatment and Diagnosis collaborates with other National Cancer Institute components as the world‘s largest sponsor of clinical cancer research. The Division of Cancer Treatment and Diagnosis (DCTD) collaborates with other National Cancer Institute (NCI) components as the world’s largest sponsor of clinical cancer research. The multidisciplinary staff members of DCTD identify the most promising areas of science and technology for development of better diagnostic and therapeutic interventions for patients with cancer. A roster listing full-time DCTD staff as well as contractors is appended to this report. The division takes prospective detection and treatment leads, facilitates their paths to clinical application, and expedites the initial and subsequent large-scale testing of new agents and interventions in patients. By determining the highest priority questions that can be examined in the laboratory and through clinical trials, DCTD ensures that appropriate mechanisms and resources are available for the development of novel interventions for the wide range of cancers affecting children and adults. Another major objective for the division is increasing the scientific depth at which new treatments are being evaluated while coordinating the administration and conduct of clinical trials with all other NCI components involved in the pursuit of clinical studies. O V E R V I E W DCTD scientists support programs to pursue high-risk research that may yield great benefits for patients with cancer but may be too difficult or risky for industry or academia to undertake. This includes a particular emphasis on the development of unique molecular signatures for cancer and molecular assays and imaging techniques that will guide oncologic therapy in the future. D I V I S I O N O F C A N C E R T R E A T M E N T A N D D I A G N O S I S ■ 1
Dr. James H. Doroshow, Director James H. Doroshow, M.D., FACP, has been the Director of the Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute (NCI), National Institutes of Health (NIH), since 2004. He fosters collaboration with other NCI divisions and offices, as well as extramural scientists and clinicians, patient advocates, and professional cancer organizations. He leads the DCTD professional staff, who represent a wide array of scientific specialties, to integrate their insights and skills into a crossdisciplinary, scientifically driven, cooperative research endeavor to discover and develop better diagnostic and therapeutic interventions for cancer. Dr. Doroshow also oversees his own active laboratory program focusing on two lines of research: discovering the mechanisms that drive the anthracycline antibiotic cell death program and understanding the role of oxidative signals in the development and treatment of colon cancer. From 1983 to 2004, Dr. Doroshow was the Associate Director for Clinical Research at the City of Hope’s (COH) Comprehensive Cancer Center in Duarte, California; the Chairman of the COH Department of Medical Oncology and Therapeutics Research; and the Leader of the COH Cancer Center’s Clinical and Experimental Therapeutics Program. Through these roles, he oversaw solid tumor therapeutic research, supervised a staff of 75 involved in investigating novel targeted agents and other therapies, and directed a program of clinical research that supported more than 150 concurrently active clinical trials. While at COH, he founded an early therapeutics consortium of three NCI-designated cancer centers in California funded by both NCI’s phase I and II support grants. He was also the principal 2 ■ P R O G R A M A C C O M P L I S H M E N T S 2 0 0 6 investigator for COH’s membership in the Southwest Oncology Group (SWOG) and founding Chair of the SWOG Early Therapeutics Committee. From the time he received his first research grant in 1980, Dr. Doroshow was funded continuously by NCI and NIH until moving to NCI in 2004. He is the author of more than 300 full-length publications in the areas of the molecular and clinical pharmacology of the anthracycline antibiotics, the role of oxidant stress in signal transduction, and novel therapeutic approaches to breast, gastrointestinal, lung, and gynecologic cancer. Dr. Doroshow is a senior editor of Clinical Cancer Research. He is a member of the editorial boards of International Journal of Oncology, Technology in Cancer Research and Treatment, and Oncology. He is also an associate editor for the widely used Manual of Clinical Oncology published by the International Union Against Cancer. Dr. Doroshow served from 1995 to 2001 as a member of the Subspecialty Board on Medical Oncology of the American Board of Internal Medicine, from 1999 to 2000 as Chair of NCI’s Scientific Review Group A- Cancer Centers, and from 1990 to 1992 as Chair of the NIH Experimental Therapeutics II Study Section. He is currently a member of the U.S. Food and Drug Administration Oncologic Drugs Advisory Committee. Dr. Doroshow received his bachelor’s degree, magna cum laude, from Harvard College in 1969 and his medical degree, Alpha Omega Alpha, from Harvard Medical School in 1973. After completing an internship and residency at Massachusetts General Hospital in Boston, he spent three years (1975–1978) at NCI as a clinical associate. He is board-certified in internal medicine and medical oncology. Prior to joining COH in 1981, he held the position of Assistant Professor of Medicine in the Division of Medical Oncology at the University of Southern California School of Medicine in Los Angeles.
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DIVISION OF CANCER TREATMENT AND DIAGNOSIS<br />
The <strong>Division</strong> <strong>of</strong> <strong>Cancer</strong> <strong>Treatment</strong> <strong>and</strong> Diagnosis<br />
collaborates with other <strong>National</strong> <strong>Cancer</strong> <strong>Institute</strong> components<br />
as the world‘s largest sponsor <strong>of</strong> clinical cancer research.<br />
The <strong>Division</strong> <strong>of</strong> <strong>Cancer</strong> <strong>Treatment</strong> <strong>and</strong><br />
Diagnosis (DCTD) collaborates with<br />
other <strong>National</strong> <strong>Cancer</strong> <strong>Institute</strong> (<strong>NCI</strong>)<br />
components as the world’s largest sponsor<br />
<strong>of</strong> clinical cancer research.<br />
The multidisciplinary staff members <strong>of</strong><br />
DCTD identify the most promising areas<br />
<strong>of</strong> science <strong>and</strong> technology for development<br />
<strong>of</strong> better diagnostic <strong>and</strong> therapeutic<br />
interventions for patients with cancer. A<br />
roster listing full-time DCTD staff as well<br />
as contractors is appended to this report.<br />
The division takes prospective detection<br />
<strong>and</strong> treatment leads, facilitates their paths<br />
to clinical application, <strong>and</strong> expedites the<br />
initial <strong>and</strong> subsequent large-scale testing<br />
<strong>of</strong> new agents <strong>and</strong> interventions in<br />
patients. By determining the highest<br />
priority questions that can be examined<br />
in the laboratory <strong>and</strong> through clinical<br />
trials, DCTD ensures that appropriate<br />
mechanisms <strong>and</strong> resources are available<br />
for the development <strong>of</strong> novel interventions<br />
for the wide range <strong>of</strong> cancers<br />
affecting children <strong>and</strong> adults.<br />
Another major objective for the division<br />
is increasing the scientific depth at which<br />
new treatments are being evaluated<br />
while coordinating the administration<br />
<strong>and</strong> conduct <strong>of</strong> clinical trials with all<br />
other <strong>NCI</strong> components involved in the<br />
pursuit <strong>of</strong> clinical studies.<br />
O V E R V I E W<br />
DCTD scientists support programs to<br />
pursue high-risk research that may yield<br />
great benefits for patients with cancer<br />
but may be too difficult or risky for<br />
industry or academia to undertake. This<br />
includes a particular emphasis on the<br />
development <strong>of</strong> unique molecular<br />
signatures for cancer <strong>and</strong> molecular<br />
assays <strong>and</strong> imaging techniques that will<br />
guide oncologic therapy in the future.<br />
D I V I S I O N O F C A N C E R T R E A T M E N T A N D D I A G N O S I S ■ 1