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Table 1. Demographics and operative characteristics<br />

evaluation of long-term morbid<strong>it</strong>y and mortal<strong>it</strong>y. Local<br />

ethic comm<strong>it</strong>tee approval was obtained for <strong>the</strong> protocol of<br />

<strong>the</strong> application of TNP to <strong>the</strong> open chest in 2004.<br />

STATISTICAL ANALYSIS<br />

Statistical analysis was performed w<strong>it</strong>h SPSS for Windows<br />

(version 14, SPSS Inc. Chicago, USA). Continuous variables<br />

are expressed as mean ± SD. Categorical variables are<br />

presented as absolute numbers in add<strong>it</strong>ion to percentages.<br />

Categorical data was compared by X 2 test and Fisher exact<br />

test. Student´s t test or Mann-Wh<strong>it</strong>ney test were used to<br />

compare continuous data. Survival was plotted using <strong>the</strong><br />

Kaplan-Meier method for <strong>all</strong> patients. A p-value of less<br />

than 0.05 was considered significant. Analysis was based<br />

on <strong>the</strong> intention-to-treat principle.<br />

RESULTS<br />

Comparing demographic and operative characteristics, no<br />

significant differences were found between both groups<br />

(Table 1). Likewise, comparable number of patients underwent<br />

reopening of <strong>the</strong> chest for bleeding or cardiac<br />

tamponade (12% vs. 8%, NS) in <strong>the</strong> intermediate postoperative<br />

course, however, in <strong>the</strong> TNP group <strong>the</strong>re was<br />

a higher number of later chest revisions for mechanical<br />

sternal instabil<strong>it</strong>y prior to DSWI compared w<strong>it</strong>h <strong>the</strong><br />

CONV group (44% vs. 21%, p

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