2017-4

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Advisory Board of This Issue (December 2017)Abdulahad Doğan, TurkeyAhmet Emre Eşkazan, TurkeyAhmet Muzaffer Demir, TurkeyAkif Selim Yavuz, TurkeyAnıl Tombak, TurkeyBülent Eser, TurkeyBurhan Engin, TurkeyCem Ar, TurkeyChloe Anthlas, UKDilber Talia İleri, TurkeyDushyant Kumar, IndiaDüzgün Özatlı, TurkeyEbru Koca, TurkeyEmre Tekgündüz, TurkeyEngin Özçivici, TurkeyErdal Karaöz, TurkeyErdal Kurtoğlu, TurkeyEren Altun, TurkeyGraeme Quest, CanadaHale Ören, TurkeyHandan Dinçaslan, TurkeyHüseyin Onay, TurkeyJames Yu, USAJamile Shammo, USAJansen Seheult, USAJohn M. Bennett, USAKanjaksha Ghosh, IndiaMahmut Bayık, TurkeyMajid Shahabi, IranMaria Papaioannou, GreeceMehmet Sönmez, TurkeyMelih Aktan, TurkeyMeral Beksaç, TurkeyMichael Grever, USAMüge Sayitoğlu, TurkeyMutlu Arat, TurkeyNader Cohan, IranNejat Akar, TurkeyOliver Karanfılski, MacedoniaPoojan Agarwal, IndiaRajat Kumar Agarwal, IndiaRejin Kebudi, TurkeyRosemary Sparrow, AustraliaRuchi Gupta, IndiaRümeyza Kazancıoğlu, TurkeySema Anak, TurkeySevil Çatal, TurkeySigbjørn Berentsen, NorwaySujata Mallick, IndiaTamar Tadmor, IsraelTiraje Celkan, TurkeyTürkan Patıroğlu, TurkeyUjjwayini Ray, IndiaÜmit Yavuz Malkan, TurkeyVildan Güngörer, TurkeyVildan Özkocaman, TurkeyVolkan Hazar, TurkeyYahya Büyükaşık, TurkeyYüksel Aliyazıcıoğlu, Turkey
REVIEWDOI: 10.4274/tjh.2017.0197Turk J Hematol 2017;34:282-288The Scope of Kidney Affection in Monoclonal Gammopathies at AllLevels of Clinical SignificanceMonoclonal Gammopatilerin Her Klinik Evresinde Böbrek Etkilenim PaternleriŞadiye Mehtat Ünlü 1 , Hayri Özsan 2 , Sülen Sarıoğlu 11Dokuz Eylül University Faculty of Medicine, Department of Pathology, İzmir, Turkey2Dokuz Eylül University Faculty of Medicine, Department of Hematology, İzmir, TurkeyAbstractMultiple myeloma (MM) is one of the most important clonal malignantplasma cell disorders and renal involvement is associated with poorprognosis. Although there are several reasons for renal impairmentin MM, the main cause is the toxic effects of monoclonal proteins.Although cast nephropathy is the best known and unchallengeddiagnosis for hematologists and pathologists, the renal effects ofmonoclonal gammopathy can be various. Monoclonal gammopathyof renal significance was proposed by the International Kidneyand Monoclonal Gammopathy Research Group for renal lesions inmonoclonal gammopathy in recent years. Renal lesions in monoclonalgammopathy can be grouped as follows: light chain (cast) nephropathy,acute tubular injury/necrosis, tubulointerstitial nephritis, amyloidosis,monoclonal Ig deposition diseases, immunotactoid glomerulopathy,type I cryoglobulinemia, proliferative glomerulonephritis withmonoclonal IgG deposits, C3 glomerulopathy with monoclonalgammopathy, and crystal-storing histiocytosis, considering theprevious and new terminology. In this study, renal involvement ofmonoclonal gammopathies, in terms of previous and new terminology,was reviewed.Keywords: Monoclonal gammopathy of renal significance, Plasmacell disorders, Multiple myeloma, Renal involvement, Kidney, CastnephropathyÖzMultipl miyelom (MM) malign plazma hücre hastalıklarının enönemlilerinden biridir ve böbrek tutulumu kötü prognozla ilişkilidir.Multipl miyelomda böbrek fonksiyonunu etkileyecek çeşitli faktörlerbulunmakla birlikte ana etken monoklonal proteinlerin toksik etkisidir.Monoklonal gammopatilerde böbrek tutulumları içinde hematologve patologlar tarafından en iyi bilinen ve tanısı sorunsuz olan “kastnefropatisi” olmakla birlikte çok farklı tutulum tipleri olabilir. Yakınzamanda “International Kidney and Monoclonal GammopathyResearch Group” tarafından, monoklonal gammopatilerdeki böbrektutulumlarını bir çatı altında toplayan “renal öneme sahip monoklonalgammopati” terimi önerildi. Monoklonal gammopatilerdeki böbreklezyonları, önceki ve yeni terminoloji uyarınca; hafif zincir kastnefropati, akut tübüler zedelenme/nekroz, tubulointerstisyelnefrit, amiloidoz, monoklonal Ig depo hastalıkları, immünotaktoidglomerülopati, tip I kriyoglobulinemi, monoklonal IgG depozitiilişkili proliferatif glomerülonefrit, monoklonal gammopati ilişkili C3glomerülopati ve kristal/histiyosit depo hastalığı olarak gruplanabilir.Bu makalede, monoklonal gammopatilerdeki böbrek tutulumu yeni veönceki terminolojiler gözden geçirildi.Anahtar Sözcükler: Renal öneme sahip monoklonal gammopati,Plazma hücre hastalıkları, Multipl miyelom, Böbrek tutulumu, Böbrek,Kast nefropatiIntroductionEach specific immunoglobulin (Ig) molecule, which is synthesizedby plasma cells, includes two identical heavy chains and twolight chains (LCs). There are 5 types of heavy chains (ϒ/α/μ/δ/Є),and immunoglobulins get their names (IgG, IgA, IgM, IgD, IgE)according to these, while there are 2 types of LC (К/λ). Eachheavy chain and LC has constant domains and variable domains.Variable domains include the antigen-binding region. Heavychains and LCs are synthesized independently of each other andfinally unite in the endoplasmic reticulum, and the structurecalled immunoglobulin is unified here [1,2].Normally, LCs are freely filtered through the glomerular basalmembrane because they are low-molecular-weight proteinsand are reabsorbed by the proximal tubules, endocytosed andcatabolized in the lysosome. After the catabolization process,their amino acids return to the circulation. There are cubilinmegalinreceptors on the brush-border of proximal tubular cells,which are very important for the control of LC endocytosis.©Copyright 2017 by Turkish Society of HematologyTurkish Journal of Hematology, Published by Galenos Publishing HouseAddress for Correspondence/Yazışma Adresi: Şadiye Mehtat ÜNLÜ, M.D.,Dokuz Eylül University Faculty of Medicine, Department of Pathology, İzmir, TurkeyPhone : +90 232 412 34 15E-mail : mehtat.unlu@deu.edu.tr ORCID-ID: orcid.org/0000-0002-7170-7594Received/Geliş tarihi: May 18, 2017Accepted/Kabul tarihi: August 22, 2017282
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Zengin E, et al: Infection-Related
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Yıldıran A, et al: HSC Transplant
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LETTERS TO THE EDITORTurk J Hematol
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LETTERS TO THE EDITOR Turk J Hemato
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AUTHOR INDEX 201734 th Volume Index
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AUTHOR INDEX 2017Serkan Güvenç...
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SUBJECT INDEX 2017Status epilepticu
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SUBJECT INDEX 2017Chronic lymphocyt
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SUBJECT INDEX 2017Single nucleotide
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SUBJECT INDEX 2017Megakaryocytic em
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2017-4

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