World Journal of Pharmaceutical research - WJPR!

Patel Sunilkumar World Journal of Pharmaceutical research
Figure 2. In-vitro dissolution profiles for tablets of batches f1 to f7 (Using dissolution
apparatus)
Ibuprofen is chiral propionic acid derivative belonging to the class of non-steroidal anti-
inflammatory drugs (NSAIDs). Due to its analgesic, antipyretic and anti inflammatory
actions it is used in the treatment of inflammatory condition such as rheumatoid arthritis ,
osteoarthritis , ankylosing spondyolitis, mild and moderate pain, dysmenorrheal, vascular
heads and fever. The dose level as an anti-rheumatic for adults is about 1.2 to 3.2 g orally per
day in 3 or 4 divided doses. The common dosage ranges are tablets with 200 mg, 400 mg, 600
mg and 800 mg and slow release tablets with 800 mg. The OTC dosage forms are mainly the
200 mg and 400 mg form s (except for the United States and other countries, here the200 mg
form is the only OTC form). Ibuprofen is readily absorbed by the gastrointestinal tract. The
peak plasma levels are reached within 1 – 2 h. After an oral dose of 200 – 400 mg, 15 – 25
mg/ml appear in the blood serum. Ibuprofen has an extensive protein binding capacity (99%).
Ibuprofen is excreted via the kidneys. The biological half-life is about 2 hours. After 24 h
100% of the active substance is excreted in the urine.
Ibuprofen with all material that developments of sustained release dosage form. In study
HPMCk4M and Ethyl cellulose which were used in different Ratio and check optimize
weighting for suitable sustained release dosage and using hydrophilic matrix polymer and
hydrophobic matrix polymer resepectly. Batches of ibuprofen were formulated with using
HPMC K4M, Ethyl cellulose, PEG600, Lactose, magnesium stearate and talc shown table1.
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%Cumulative Release
90
80
70
60
50
40
30
20
10
0
0 5 10 15
Time in hr
BATCH1
BATCH2
BATCH3
BATCH4
BATCH5
BATCH6
BATCH7
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