World Journal of Pharmaceutical research - WJPR!

Time
(hr)
Patel Sunilkumar World Journal of Pharmaceutical research
Post-Compression Evaluations of Ibuprofen Sustained Matrix Tablets
Table 5: Evaluation of Tablets
Batch
Code
In-Vitro Drug Release Studies
Table 6: In-Vitro Drug Release Studies of Ibuprofen sustained release tablets
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Weight
Variation
Average
Wt in
(mg)±SD
Hardness
(kg/cm 2 )
±SD
Diamete
r
(mm)
±SD
% Cumulative Release
Thicknes
s
(mm)
±SD
Friability
%±SD
Drug Release
%±SD
F1 259±5.0 4.4±0.5 8.5±0.03 5.5±0.01 0.56±0.01 81.99±0.56
F2 265±5.5 4.1±0.4 8.5±0.02 5.5±0.04 0.58±0.04 78.04±0.16
F3 255±5.1 3.4±0.6 8.5±0.04 5.3±0.02 0.63±0.02 71.34±0.96
F4 260±5.5 3.85±0.5 8.7±0.01 5.3±0.01 0.60±0.01 62.11±0.10
F5 270±5.1 3.5±0.3 8.5±0.02 5.3±0.03 0.62±0.03 68.47±0.51
F6 260±5.3 3.1±0.6 8.7±0.03 5.3±0.02 0.67±0.01 74.82±0.64
F7 255±5.1 3.80±0.4 8.5±0.01 5.3±0.01 0.59±0.02 65.23±0.15
F1±SD F2±SD F3±SD F4±SD F5±SD F6±SD F7±SD
0.5 18.05±0.56 17.09±0.10 15.01±0.57 12.06±0.49 14.03±1.21 16.07±1.01 13.01±0.53
1 24.23±1.11 23.51±0.38 21.14±0.51 18.32±0.85 20.44±0.54 22.02±0.64 19.19±0.52
2 31.24±1.07 29.05±0.50 26.71±0.70 23.12±0.70 25.62±0.47 27.37±0.44 24.11±0.81
3 37.44±0.83 35.19±0.01 31.57±0.60 27.79±0.66 30.21±0.99 33.03±0.19 28.89±0.24
4 43.01±0.54 41.17±0.17 37.56±0.52 31.32±0.44 35.23±1.56 39.69±0.63 33.46±1.03
5 49.59±0.12 46.21±0.98 42.09±0.78 35.37±0.32 40.34±0.90 44.12±0.39 37.34±1.15
6 54.43±0.04 51.34±1.13 47.39±0.17 39.55±1.26 44.83±0.46 49.58±0.94 41.21±0.21
7 59.32±0.49 56.48±1.04 51.52±0.66 42.71±0.24 48.42±0.30 54.66±0.50 45.33±0.46
8 64.49±1.09 61.55±0.41 55.66±0.54 46.93±0.06 52.69±0.23 58.81±0.87 49.51±0.31
9 68.62±1.07 65.69±0.60 59.75±0.45 50.56±0.68 56.88±0.47 62.93±0.51 53.73±0.66
10 72.86±1.06 69.77±0.02 63.92±0.35 54.71±0.48 60.99±0.62 66.44±0.72 57.91±0.49
11 77.18±0.76 73.82±0.76 67.09±0.09 58.86±0.88 64.26±0.59 70.65±0.28 61.62±0.27
12 1.99±0.40 78.04±0.25 71.34±0.62 62.11±1.17 68.47±1.12 74.82±0.54 65.23±0.34
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