World Journal of Pharmaceutical research - WJPR!

Patel Sunilkumar World Journal of Pharmaceutical research
Composition of Ibuprofen Sustained Release Tablets
Table 2: Different Formulation for Ibuprofen Sustained Release Tablet
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Ingredients F1 F2 F3 F4 F5 F6 F7
Ibuprofen 200 200 200 200 200 200 200
EC --- 100 -- -- -- -- --
HPMC 100 -- -- -- -- -- --
EC:HPMC -- -- 60:40 40:60 50:50 75:25 25:75
PEG 4000 7.2 7.2 7.2 7.2 7.2 7.2 7.2
Lactose 50.86 50.86 50.86 50.86 50.86 50.86 50.86
Magnesium
Stearate
1.94 1.94 1.94 1.94 1.94 1.94 1.94
*HPMC K4M and EC indicate Hydroxypropylmethylcellulose and Ethyl cellulose all batches
contained 200mg of Ibuprofen.
Pre-Compression Evaluations of Ibuprofen Sustained Matrix Tablets
Table 3: Physical Properties of Ingredients
Ingredient
(10gm)
Bulk
Density
(gm/cm 3 )
Tapped
Density
(gm/cm 3 )
Hausner’s
ratio
Card’s index
Angle of
Repose
Ibuprofen 0.555 0.588 1.06 5.61 26.29 0
HPMC 0.540 0.606 1.12 10.89 20.18 0
EC 0.298 0.322 1.08 7.45 22.25 0
Table 4: Evaluation of Different Power Blends
Batch
Code
Bulk
density
(gm/cm 3 )
Tapped
density
(gm/cm 3 )
Hausner’s
ratio
(HR)
Carr’s index
(Ic)
Angle of
repose
(ø)
F1 0.404 0.505 1.25 20.00 20.37 0
F2 0.394 0.476 1.20 17.22 22.56 0
F3 0.394 0.446 1.13 11.66 12.62 0
F4 0.381 0.469 1.23 18.76 17.90 0
F5 0.385 0.468 1.21 17.73 16.85 0
F6 0.340 0.432 1.27 21.29 17.96 0
F7 0.402 0.512 1.27 21.48 17.03 0
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