World Journal of Pharmaceutical research - WJPR!
World Journal of Pharmaceutical research - WJPR!
World Journal of Pharmaceutical research - WJPR!
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Patel Sunilkumar <strong>World</strong> <strong>Journal</strong> <strong>of</strong> <strong>Pharmaceutical</strong> <strong>research</strong><br />
Composition <strong>of</strong> Ibupr<strong>of</strong>en Sustained Release Tablets<br />
Table 2: Different Formulation for Ibupr<strong>of</strong>en Sustained Release Tablet<br />
www.wjpr.net<br />
Ingredients F1 F2 F3 F4 F5 F6 F7<br />
Ibupr<strong>of</strong>en 200 200 200 200 200 200 200<br />
EC --- 100 -- -- -- -- --<br />
HPMC 100 -- -- -- -- -- --<br />
EC:HPMC -- -- 60:40 40:60 50:50 75:25 25:75<br />
PEG 4000 7.2 7.2 7.2 7.2 7.2 7.2 7.2<br />
Lactose 50.86 50.86 50.86 50.86 50.86 50.86 50.86<br />
Magnesium<br />
Stearate<br />
1.94 1.94 1.94 1.94 1.94 1.94 1.94<br />
*HPMC K4M and EC indicate Hydroxypropylmethylcellulose and Ethyl cellulose all batches<br />
contained 200mg <strong>of</strong> Ibupr<strong>of</strong>en.<br />
Pre-Compression Evaluations <strong>of</strong> Ibupr<strong>of</strong>en Sustained Matrix Tablets<br />
Table 3: Physical Properties <strong>of</strong> Ingredients<br />
Ingredient<br />
(10gm)<br />
Bulk<br />
Density<br />
(gm/cm 3 )<br />
Tapped<br />
Density<br />
(gm/cm 3 )<br />
Hausner’s<br />
ratio<br />
Card’s index<br />
Angle <strong>of</strong><br />
Repose<br />
Ibupr<strong>of</strong>en 0.555 0.588 1.06 5.61 26.29 0<br />
HPMC 0.540 0.606 1.12 10.89 20.18 0<br />
EC 0.298 0.322 1.08 7.45 22.25 0<br />
Table 4: Evaluation <strong>of</strong> Different Power Blends<br />
Batch<br />
Code<br />
Bulk<br />
density<br />
(gm/cm 3 )<br />
Tapped<br />
density<br />
(gm/cm 3 )<br />
Hausner’s<br />
ratio<br />
(HR)<br />
Carr’s index<br />
(Ic)<br />
Angle <strong>of</strong><br />
repose<br />
(ø)<br />
F1 0.404 0.505 1.25 20.00 20.37 0<br />
F2 0.394 0.476 1.20 17.22 22.56 0<br />
F3 0.394 0.446 1.13 11.66 12.62 0<br />
F4 0.381 0.469 1.23 18.76 17.90 0<br />
F5 0.385 0.468 1.21 17.73 16.85 0<br />
F6 0.340 0.432 1.27 21.29 17.96 0<br />
F7 0.402 0.512 1.27 21.48 17.03 0<br />
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