World Journal of Pharmaceutical research - WJPR!

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Patel Sunilkumar World Journal of Pharmaceutical research osteoarthritis, ankylosing spondylitis, mild and moderate pain, dysmenorrhoea, vascular heads and fever. The dose level as an anti-rheumatic for adults is about 1.2 to 3.2 g orally per day in 3 or 4 divided doses. The common dosage ranges are tablets with 200 mg, 400 mg, 600 mg and 800 mg and slow release tablets with 800 mg. The OTC dosage forms are mainly the 200 mg and 400 mg forms (except for the United States and other countries, here the 200 mg forms is the only OTC form). Ibuprofen is readily absorbed by the gastrointestinal tract. The peak plasma levels are reached within 1 – 2 h. After an oral dose of 200 – 400 mg, 15 – 25 mg/ml appear in the blood serum. Ibuprofen has an extensive protein binding capacity (99%). Ibuprofen is excreted via the kidneys. The biological half-life is 2 hours. After 24 h 100% of the active substance is excreted in the urine. [1,2] Ibuprofen is slight soluble in water, and hence judicious selection of release-retarding excipients is necessary to achieve a constant in vivo input rate of the drug. Most commonly used method of modulating the drug release is to include it in a matrix system. Because of their flexibility, hydrophilic polymer matrix systems are widely used in oral controlled drug delivery to obtain a desirable drug release profile, cost effectiveness, and broad regulatory acceptance. hence, in the present work and attempt has been made to develop once-daily sustained release matrix tablets of Ibuprofen using hydrophilic matrix materials and hydrophobic material such as hydroxypropylmethylcellulose (HPMC), Ethyl Cellulose(EC) and PEG 600. [3,4] Drug release for extended duration, particularly for highly water-soluble drugs, using a hydrophilic and Hydrophobic matrix system is restricted because of rapid diffusion of the dissolved drug through the hydrophilic and hydrophobic gel network. For such drugs with high water solubility, hydrophobic polymers are suitable, along with a hydrophilic matrix for developing sustained-release dosage forms. Hydrophobic polymers provide several advantages, ranging from good stability at varying pH values and moisture levels to well established safe applications. Therefore, in this study, the hydrophobic polymers like ethyl cellulose (EC) were used. Main objective of study was to formulate and evaluation of sustained release dosage form by different polymer material to investigate the effect of Polymer. [8] www.wjpr.net 1331
Patel Sunilkumar World Journal of Pharmaceutical research MATERIAL AND METHODS MATERIAL Ibuprofen was procured from Ratmani Pharmaceutical pvt Ltd Mehsana. Hydroxypropyl methylcellulose K4M (HPMC K4M) was obtained from Purui Enterprise pvt ltd Ahmedabad. Ethyl Cellulose was obtained from Chemeco company pvt ltd Ahmedabad.PEG was obtained from Shital Chemical, Ahmedabad. Lactose, Magnesium stearate, and talc were purchased from Shital Chemical pvt ltd, Ahmedabad. All other materials and chemicals used were of either pharmaceutical or analytical grade. METHODS Tablet Preparation Ibuprofen Sustained Release matrix tablets were prepared by Wet granulation technique. 7,8 Drug was passed through 40# sieve. HPMC K 4M, Ethyl cellulose, Lactose, PEG 400 were passed through 30# sieve. All other ingredients were passed through 40# sieve. All ingredients were mixed for 15-20 min. After mixing, Mg. stearate (60# sieve) and Talc were added to mixer blend and mix again for 3-5 min. Prepared blend was compressed (10/30 diameter, flat punches) using Multi Rotary Tablet Machine (Type: Patel services pvt ltd, Ahemdabad). Each tablet contains 200 mg of Ibuprofen and other pharmaceuticals ingredients as listed in Table 1. EVALUATION OF POWDER AND POWER BLEND Angle of Repose Angle of Repose of Power and Power blend were determined by the funnel method. Accurately weight powder blend were taken in the funnel. Height of the funnel was adjusted in such a way the tip of the funnel just touched the apex of the powder blend. Powder blend was allowed to flow through the funnel freely on to the surface. Diameter of the powder cone was measured and angle of repose was calculated using the following equation. [3],[4] Tan α = h/r DENSITY Bulk Density (BD) Weigh accurately 10 g of Power and Power blend, which were previously passed through 20# sieve and transferred in 100 ml graduated cylinder. Carefully level the powder without www.wjpr.net 1332
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