World Journal of Pharmaceutical research - WJPR!

Patel Sunilkumar World Journal of Pharmaceutical research
osteoarthritis, ankylosing spondylitis, mild and moderate pain, dysmenorrhoea, vascular
heads and fever. The dose level as an anti-rheumatic for adults is about 1.2 to 3.2 g orally per
day in 3 or 4 divided doses. The common dosage ranges are tablets with 200 mg, 400 mg, 600
mg and 800 mg and slow release tablets with 800 mg. The OTC dosage forms are mainly the
200 mg and 400 mg forms (except for the United States and other countries, here the 200 mg
forms is the only OTC form). Ibuprofen is readily absorbed by the gastrointestinal tract. The
peak plasma levels are reached within 1 – 2 h. After an oral dose of 200 – 400 mg, 15 – 25
mg/ml appear in the blood serum. Ibuprofen has an extensive protein binding capacity (99%).
Ibuprofen is excreted via the kidneys. The biological half-life is 2 hours. After 24 h 100% of
the active substance is excreted in the urine. [1,2]
Ibuprofen is slight soluble in water, and hence judicious selection of release-retarding
excipients is necessary to achieve a constant in vivo input rate of the drug. Most commonly
used method of modulating the drug release is to include it in a matrix system. Because of
their flexibility, hydrophilic polymer matrix systems are widely used in oral controlled drug
delivery to obtain a desirable drug release profile, cost effectiveness, and broad regulatory
acceptance. hence, in the present work and attempt has been made to develop once-daily
sustained release matrix tablets of Ibuprofen using hydrophilic matrix materials and
hydrophobic material such as hydroxypropylmethylcellulose (HPMC), Ethyl Cellulose(EC)
and PEG 600. [3,4]
Drug release for extended duration, particularly for highly water-soluble drugs, using a
hydrophilic and Hydrophobic matrix system is restricted because of rapid diffusion of the
dissolved drug through the hydrophilic and hydrophobic gel network. For such drugs with
high water solubility, hydrophobic polymers are suitable, along with a hydrophilic matrix for
developing sustained-release dosage forms. Hydrophobic polymers provide several
advantages, ranging from good stability at varying pH values and moisture levels to well
established safe applications. Therefore, in this study, the hydrophobic polymers like ethyl
cellulose (EC) were used. Main objective of study was to formulate and evaluation of
sustained release dosage form by different polymer material to investigate the effect of
Polymer. [8]
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