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Patel Sunilkumar World Journal of Pharmaceutical research Formulated Power blend of Different batches were Evaluated. Showed results of Power blend have Bulk density and tapped density of F1 to F7 batches that 0.340 to 0.404 and 0.432 to 0.532 Respect. Carr’s Index and hausner’s ratio have good compare to std value as according to IP of F1 to F7 batches that 11.66 to 21.48 and 1.13 to 1.27 shown table 3 Respect. Angle of repose has good and Excellent as Compare standard value as According to IP of F1 to F7 Batches that 12.62 0 to 22.56 0 shown table3. Ibuprofen Tablets were Prepared successfully by wet granulation Technique. In Weight variation test, the Pharmacopoeia limit for percent of deviation for tablets of more than 260mg is ±5%. The average percent deviation of all tablets was found to be limit and hence all formulations passed the weight variation test. The hardness of tablets of all formulation was in range of 2.5±0.51 to 3.8±0.54 kg\cm 2 . The Thickness of tablets ranged from 5.204±0.01 to 5.514±0.01.i.e. less than 1%. The Diameter of tablets ranged from 8.301±0.01 to 8.520±0.01. The Friability of tablets of all formulation was in range of 0.059±0.01 to 0.065±0.01shown table 4.All thickness shown uniform thickness. The Drug content was found to be uniform all formulation and ranged from 62.11% to 81.99%. Shown in figure1 CONCLUSION Among all formulation f4 containing 40% of ehtylcellulose and 60% of Hydroxy propyl methyl cellulose showed in vitro drug release 62.11% and which is equivalent to marketed preparation hence considered as most promising formulation. Result also showed that among hydrophilic and hydrophobic matrix polymer. HPMC sustain more than EC .Combination of HPMC and EC retain drug more than that individual matrix polymer. In study concluded HPMC and EC are hydrophilic and hydrophobic matrix polymer which using matrix foaming agent by wet granular technique to sustain the release of ibuprofen. ACKNOWLEDGEMENTS We are grateful to Ratmani Pharmaceutical Ltd, Mehsana for providing gift sample of Ibuprofen. REFERENCES 1. Dabbagh M.A and Beitmashal L.Sustained Release Formulation and In-Vitro Evaluation of Ibuprofen-Hpmc Matrix Tablets. Jundishapur J Natural Pharm Products, 2006; 1:1-7. 2. Prajapati Bhupendra G., Patel Krunal R.Design and In Vitro Evaluation of Novel Nicorandil Sustained Release Matrix Tablets Based On Combination of Hydrophilic and Hydrophobic Matrix System. Int J Pharm Sci. and Res, 2010; 1(1): 2143-2156. www.wjpr.net 1339
Patel Sunilkumar World Journal of Pharmaceutical research 3. Subramaniam Kannan, Rangasamy Manivannan, Kugalur Ganesan Parthiban Kakkatummal Nishad and Natesan Senthil Kumar. Formulation and Evaluation of Sustained Release Tablets of Aceclofenac using Hydrophilic Matrix System. Int J Pharma Tech Res, 2010; 2(3):1775-1780. 4. Raghavendra raon.G, Gandhi sagar, patel tarun.Formulation And Evaluation of Sustained Release Matrix tablets of Tramadol Hydrochloride.Int J Pharm and pharmaceutical sci ,2009; 1(1):660-671. 5. Sahu Atul Kumar, Singh Shailendra Kumar and Verma Amita. Formulation Development of Buoyant Controlled Release Tablets Containing Chitosan: Optimization of In vitro Dissolution and Release Kinetics.Int J Pharma and Pharmaceutical Sci, 2011; 3(2):81-85. 6. Selvadurai Muralidharan, Subramania Nainar Meyyanathan, Kaliaperumal Krishnaraj 1 And Sekar Rajan .Development of oral Sustained release dosage form for low melting chiral compound Dexibuprofen and it’s in vitro-in vivo evaluation. Int J Drug Dev, 2011; 3:492-502. 7. Shoaib M. Harris, tazeen japery, Merchant humid a. and yousuf Rabia Ismail. Evaluation of Drug Release Kinetics from Ibuprofen Matrix Tablets Using Hpmc. Pakistan J Pharm Sci, 2006; 19(2):119-124. 8. Tiwari Sandip B., Murthy T. Krishna, Pai M. Raveendra, Mehta Pavak R., and Chowdary Pasula B.Controlled Release Formulation of Tramadol Hydrochloride Using Hydrophilic and Hydrophobic Matrix System. American Association of pharm scientists Pharm Sci Tech, 2003; 4(3):E31. 9. Bhagwat Durgacharan A, Kawtikwar Pravin S and Sakarkar Dinesh M. Sustained Release Matrices of Verapamil HCl Using Glyceryl Monosterate and Stearic Acid.Res J Pharm Tech, 2008; 1(4):405-409. 10. Yeole P.G., gatte UC, babla I B and nakhat PD. Design and Evaluation of Xanthan Gum- based Sustained Release Matrix Tablets of Dichlofenac sodium. Ind J Pharm Sci, 2006; 185-189. 11. Senthil Kumar B, Prem Anand D C, Senthil Kumar K L, Saravanakumar M and Thirumurthy R.Formulation and evaluation of diltiazem hydrochloride Extented release tablet by melt granulation technique. Int J Pharm & Indu Res, 2011; 1(1): 36-42. 12. Saleh A. Al-Suwayeh, Mohammed H. El-Shaboury, Saeed M. Al-Baraki, Abubakar S. Elgorashy and Ehab I. Taha. In Vitro and in Vivo Evaluation of Sustained Release www.wjpr.net 1340
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