World Journal of Pharmaceutical research - WJPR!

Patel Sunilkumar World Journal of Pharmaceutical research
Formulated Power blend of Different batches were Evaluated. Showed results of Power blend
have Bulk density and tapped density of F1 to F7 batches that 0.340 to 0.404 and 0.432 to
0.532 Respect. Carr’s Index and hausner’s ratio have good compare to std value as according
to IP of F1 to F7 batches that 11.66 to 21.48 and 1.13 to 1.27 shown table 3 Respect. Angle of
repose has good and Excellent as Compare standard value as According to IP of F1 to F7
Batches that 12.62 0 to 22.56 0 shown table3. Ibuprofen Tablets were Prepared successfully by
wet granulation Technique. In Weight variation test, the Pharmacopoeia limit for percent of
deviation for tablets of more than 260mg is ±5%. The average percent deviation of all tablets
was found to be limit and hence all formulations passed the weight variation test. The hardness
of tablets of all formulation was in range of 2.5±0.51 to 3.8±0.54 kg\cm 2 . The Thickness of
tablets ranged from 5.204±0.01 to 5.514±0.01.i.e. less than 1%. The Diameter of tablets
ranged from 8.301±0.01 to 8.520±0.01. The Friability of tablets of all formulation was in
range of 0.059±0.01 to 0.065±0.01shown table 4.All thickness shown uniform thickness. The
Drug content was found to be uniform all formulation and ranged from 62.11% to 81.99%.
Shown in figure1
CONCLUSION
Among all formulation f4 containing 40% of ehtylcellulose and 60% of Hydroxy propyl
methyl cellulose showed in vitro drug release 62.11% and which is equivalent to marketed
preparation hence considered as most promising formulation. Result also showed that among
hydrophilic and hydrophobic matrix polymer. HPMC sustain more than EC .Combination of
HPMC and EC retain drug more than that individual matrix polymer. In study concluded
HPMC and EC are hydrophilic and hydrophobic matrix polymer which using matrix foaming
agent by wet granular technique to sustain the release of ibuprofen.
ACKNOWLEDGEMENTS
We are grateful to Ratmani Pharmaceutical Ltd, Mehsana for providing gift sample of
Ibuprofen.
REFERENCES
1. Dabbagh M.A and Beitmashal L.Sustained Release Formulation and In-Vitro Evaluation
of Ibuprofen-Hpmc Matrix Tablets. Jundishapur J Natural Pharm Products, 2006; 1:1-7.
2. Prajapati Bhupendra G., Patel Krunal R.Design and In Vitro Evaluation of Novel
Nicorandil Sustained Release Matrix Tablets Based On Combination of Hydrophilic and
Hydrophobic Matrix System. Int J Pharm Sci. and Res, 2010; 1(1): 2143-2156.
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