Nina Wettschureck and Stefan Offermanns - Physiological Reviews
Nina Wettschureck and Stefan Offermanns - Physiological Reviews
Nina Wettschureck and Stefan Offermanns - Physiological Reviews
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1162 NINA WETTSCHURECK AND STEFAN OFFERMANNS<br />
TABLE 1—Continued<br />
Endogenous Lig<strong>and</strong>(s) Receptor<br />
Coupling to G Protein<br />
Subclass(es) Reference Nos.<br />
Amylin<br />
Angiotensin II<br />
Apelin<br />
Bradykinin<br />
Calcitonin<br />
Calcitonin gene-related peptide (CGRP)<br />
CC chemokines<br />
CXC chemokines<br />
CX3C chemokines<br />
Cholecyctokinin (CCK-8)<br />
Complement C3a/C5a<br />
Corticitropin-releasing factor (CRF),<br />
urocortin<br />
AMY1 (CT�RAMP1), AMY2 (CT�RAMP2), AMY3 (CT�RAMP3)<br />
AT1 AT2 APJ<br />
B1,B2 CT<br />
CGRP1 (CL�RAMP1)<br />
CCR1,2,3,4,5,6,7,8,9,10<br />
CXCR1,2,3,4,5,6<br />
XCL1, XCL2, CX3L1<br />
CCK1, CCK2 C3a, C5a<br />
CRF1, CRF2 Gs Gq/11, G12/13, Gi/o ?<br />
Gi/o Gq/11 Gs,Gq/11 Gs,Gq/11 Gi/o Gi/o Gi/o Gq/11, Gs Gi/o Gs 525<br />
134<br />
627<br />
378<br />
525<br />
525<br />
466, 467<br />
466, 467<br />
466, 467<br />
582<br />
208<br />
239<br />
Endothelin-1, -2, -3<br />
Follicle-stimulating hormone (FSH)<br />
Formyl-Met-Leu-Phe (fMLP)<br />
Galanin, galanin-like peptide<br />
Gastric inhibitory peptide<br />
Gastrin<br />
Gastrin-releasing peptide (GRP),<br />
bombesin<br />
ETA (ET-1, ET-2), ETB (ET-1, -2, -3)<br />
FSH<br />
FPR<br />
GAL1, GAL3<br />
GAL2<br />
GIP<br />
CCK2 BB2<br />
Gq/11, G12/13, Gs Gs Gi/o Gi/o Gi/o, Gq/11, G12/13 Gs Gq/11 Gq/11 131<br />
648<br />
373<br />
657<br />
657<br />
332, 431<br />
582<br />
36<br />
Ghrelin<br />
Glucagon<br />
Glucagon-like peptide<br />
Gonadotropin-releasing hormone<br />
Growth hormone-releasing hormone<br />
Kisspeptins, metastin<br />
Luteinizing hormone,<br />
choriogonadotropin<br />
GHS-R<br />
Glucagon<br />
GLP1, GLP2<br />
GnRH<br />
GHRH<br />
GPR54<br />
LSH<br />
Gq/11 Gs Gs Gq/11 Gs Gq/11 Gs,Gi 342<br />
431<br />
431<br />
445<br />
206, 431<br />
137, 575<br />
648<br />
Melanin-concentrating hormone<br />
Melanocortins<br />
Motilin<br />
Neurokinin-A/-B (NK-A/-B)<br />
Neuromedin-B, bombesin<br />
Neuromedin U<br />
Neuropeptide FF & AF<br />
Neuropeptide W-23, W-30<br />
Neuropeptide Y (NPY) etc.<br />
Neurotensin<br />
Opioids (�-endorphin, Met/Leuenkephalin,<br />
dynorphin A, nociceptin/<br />
orphanin FQ)<br />
MCH1<br />
MCH2<br />
MC1,MC3,MC4,MC5 GPR38<br />
NK2 (NK-A), NK3 (NK-B)<br />
BB1<br />
NMU1 (FM-3), NMU2 (FM-4)<br />
NPFF1, NPFF2<br />
GRP7, GPR8<br />
Y1,Y2,Y4,Y5,Y6 NTS1, NTS2<br />
�, �, �, ORL1<br />
Gi/o? Gq/11 Gs Gq/11 Gq/11 Gq/11 Gq/11 Gi/o Gi/o Gi/o Gq/11 Gi/o 63<br />
682<br />
173<br />
513<br />
496<br />
67<br />
54<br />
580<br />
440<br />
654<br />
370<br />
Orexin A/B<br />
Oxytocin<br />
Parathyroid hormone (related peptide)<br />
Prokineticin-1,2<br />
Prolactin-releasing peptide<br />
Relaxin, insulin-like 3<br />
Secretin<br />
Somatostatin<br />
Substance P (SP)<br />
Thyrotropin (TSH)<br />
Thyrotropin-releasing hormone (TRH)<br />
Urotensin II<br />
Vasoactive intestinal polypeptide (VIP),<br />
PACAP<br />
OX1, OX2<br />
OT<br />
PTH/PTHrP<br />
PK-R1, PK-R2<br />
PrRP (GPR10)<br />
LGR7, LGR8<br />
Secretin<br />
SST1, SST2, SST3, SST4, SST5 NK1 TSH<br />
TRH-1, TRH-2<br />
UT-II (GPR14)<br />
VPAC1, VPAC2, PAC1 Gs,Gq/11 Gq/11, Gi/o Gs,Gq/11 Gq/11 Gq/11 Gs Gs Gi/o Gq/11 Gs,Gq/11, Gi,G12/13 Gq/11 Gq/11 Gs 442<br />
256<br />
203<br />
591<br />
613<br />
35<br />
431<br />
511<br />
513<br />
648<br />
614<br />
150<br />
651<br />
Vasopressin<br />
Proteases (the new NH2-terminal domain<br />
produced by proteolytic cleavage<br />
serves as a tethered lig<strong>and</strong>)<br />
V1a, V1b V2 Gq/11 Gs 256<br />
256<br />
Thrombin <strong>and</strong> others<br />
Trypsin <strong>and</strong> others<br />
PAR-1, PAR-3, PAR-4<br />
PAR-2<br />
Gq/11, G12/13, Gi/o Gq/11 271<br />
271<br />
Physiol Rev • VOL 85 • OCTOBER 2005 • www.prv.org