Edinburgh, Scotland, United Kingdom - TAIR

A level-set model of leaf form development C36
Saturday 14:00 - 14:30
Systems Biology
A key question in biology is to understand how organismal form is generated
through the process of development. Here we focus on the development of
leaves. To this end, we integrate developmental genetics and computational
modeling to compare the mechanisms that shape the simple leaf of the model
plant Arabidopsis thaliana and the compound subdivided leaf of its close relative
Cardamine hirsuta. The models capture the feedback between the dynamic
emergence of auxin convergence points on the leaf margin, and the
development of leaf shape. Following the level-set methodology, this
development is simulated as the propagation of leaf margin over time. The
propagation rates are informed by the interplay between auxin and gene
expression in the leaf margin. We test and validate these models by interrogating
experimental data for A. thaliana, C. hirsuta and their mutants and transgenic
variants.
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Przemyslaw
Prusinkiewicz1
Miltos Tsiantis2
1University of Calgary
Alberta
Canada
2University of Oxford
UK