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Autophagic components contribute to hypersensitive cell death in Arabidopsis Recent studies implicate autophagy as a pro-survival mechanism in plants that restricts programmed cell death (PCD) associated with the pathogen-triggered hypersensitive response (HR). This model is based on the observation that HR lesions show unrestricted spreading in tobacco and Arabidopsis plants with RNAi-mediated reduction of autophagy gene expression. We examined HR PCD responses in autophagy-deficient Arabidopsis knockout mutants (atg), and report that infection-induced lesions are contained in atg mutants. HR PCD conditioned by one class of innate immune receptors through the defense regulator EDS1 is suppressed in atg mutants. Furthermore, we demonstrate that PCD triggered by immune receptors via NDR1 is either autophagy-independent or engages autophagic components with cathepsins and other unidentified cell death mediators. Thus, autophagic cell death contributes to HR PCD and can function in parallel with other pro-death pathways. 80 C29 Thursday 15:45 - 16:00 Plant Defence Daniel Hofius1 Torsten Schultz-Larsen2 Jan Joensen1 Dimitrios Tsitsigiannis3 Ole Mattsson1 Nikolaj Petersen4 Lise Jørgensen1 Jonathan D G Jones2 John Mundy1 Morten Petersen1 1Copenhagen University, Copenhagen Denmark 2Sainsbury Laboratory Norwich UK 3Agricultural University Athens Greece 4Danish Cancer Society Copenhagen Denmark
Untangling transcriptional regulatory networks modulating hormone responses The phytohormone ethylene plays critical roles in growth, defense and a myriad other plant processes by regulating the expression of large and diverse sets of genes through control of protein stabilization of the master transcriptional regulator EIN3. Using ChIP-Seq and RNA-Seq methods, we found that EIN3 is involved in a feedback loop that controls both positive and negative components in ethylene signaling. Several ethylene receptor genes are direct EIN3-binding targets, along with genes encoding CTR1 protein kinase and EBF1/EBF2, EIN3binding F-box proteins, EER5, a proteasome-related signalosome subunit that is proposed to be involved resetting the ethylene-signaling pathway, as well as RAN1 a copper transporter involved in ethylene receptor function. We also identified a number of positive regulators in the ethylene signaling pathway components among the list of EIN3 direct target genes. Confirming that a massive transcriptional cascade is a critical aspect of the diverse responses mediated by ethylene output pathways, we identified many AP2/ERF and WRKY transcription factors as direct EIN3 binding targets; several of which are known to be involved in mediating responses to pathogens. In addition, we identified key points of hormone crosstalk of ethylene with other hormones. Direct EIN3 targets included several of the master regulatory transcription factors controlling growth regulation by other hormones, revealing new (and direct) connections among these signaling pathways. Additional EIN3 targets include enzymes for hormone biosynthesis or conjugation, further supporting the existence of connections among hormone pathways. Finally, we merged the EIN3-target information with global gene expression information and a large protein-protein interaction network (Braun et al. CCSB-Harvard/Salk, unpublished) to establish a first generation hormone interactome network map. As indicated by the multitude of connections between different nodes in the network, EIN3 targets encompass numerous hormone biosynthesis and signaling pathways which can now be further explored. 81 C30 Thursday 14:00 - 14:30 Plant Growth Regulators Katherine N Chang Hong Qiao Dwight Kuo Trey Ideker Joseph R Ecker The Salk Institute La Jolla CA Univ. of Calif San Diego USA
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20 th International Conference on A
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Organising & Scientific Committee D
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At a Glance Programme Tuesday 30 th
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ICAR 2009 Programme Wednesday 1 st
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ICAR 2009 Programme Wednesday 1 st
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ICAR 2009 Programme Thursday 2 nd J
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ICAR 2009 Programme Saturday 4 th J
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ICAR Supporters ICAR 2009 gratefull
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of the conference. Hard copies of t
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Local Information Welcome to Edinbu
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Keynote Speakers Professor David Ba
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Mechanism and function of active DN
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DNA methylation and transgeneration
Page 32 and 33: Architecture from stem cell centred
Page 34 and 35: The responses of stomata to environ
Page 36 and 37: Low oxygen stress: What is more imp
Page 38 and 39: Effectors affect distal effects; pl
Page 40 and 41: Genome-wide association study of 10
Page 42 and 43: Predicting flowering time in changi
Page 44 and 45: Cellular dynamics in plant immunity
Page 46 and 47: Timing is everything: exploring lin
Page 48 and 49: Regulation of shade avoidance by a
Page 50 and 51: Systems analysis of the diurnal reg
Page 53 and 54: Concurrent Abstracts 51
Page 55 and 56: Uniparental expression of PolIV-dep
Page 57 and 58: The circadian clock controls carboh
Page 59 and 60: Local-scale population structure an
Page 61 and 62: Identification of CO 2 -binding pro
Page 63 and 64: Towards a spatiotemporal understand
Page 65 and 66: Sequencing across the genome-phenom
Page 67 and 68: EZ-Rhizo: New software for fast and
Page 69 and 70: Evidence of neutral transcriptome e
Page 71 and 72: Signalling modules controlling the
Page 73 and 74: Asymmetry, pattern and renewal in A
Page 75 and 76: Leaf size is regulated by a cell-au
Page 77 and 78: Using pathogen effectors to underst
Page 79 and 80: Endocytic trafficking: New players
Page 81: New classes of proteins forming com
Page 85 and 86: Cytokinin signaling: Two-components
Page 87 and 88: Dynamic, auxin-responsive plasma me
Page 89 and 90: A level-set model of leaf form deve
Page 91 and 92: Modelling cell division in the Arab
Page 93 and 94: A systems biology approach to under
Page 95 and 96: Arabidopsis as a model for cell wal
Page 97 and 98: Exploiting model species to increas
Page 99: Using Arabidopsis thaliana to impro
Page 102 and 103: Epigenetic regulation of cartenoid
Page 104 and 105: The last common ancestor of ferns a
Page 106 and 107: Resetting and regulation of Floweri
Page 108 and 109: Functional redundancy and spatial e
Page 110 and 111: Dynamic interactions of vernalizati
Page 112 and 113: Analysis of the Arabidopsis AtMYB60
Page 114 and 115: The early bird 1 reveals a new cog
Page 116 and 117: Posttranslational modifications of
Page 118 and 119: Isolation and identification of ubi
Page 120 and 121: Shedding light upon the plant circa
Page 122 and 123: Transcriptome profiling of RNA-proc
Page 124 and 125: Plant Growth Regulators A subunit o
Page 126 and 127: Tissue identity shapes growth respo
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Page 130 and 131: Descriptions and Programmes Tuesday
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Thursday 2 nd July 16:30 - 18:00 1
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Saturday 4 th July 16:30 - 18:00 1
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Exhibition The ICAR 2009 Exhibition
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Stand 1 Journal of Experimental Bot
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Stand 10 Agrisera Agrisera is a Swe
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Notes 140
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Edinburgh, Scotland, United Kingdom - TAIR

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