chapter 2 palladium catalysts in suzuki cross- coupling reaction
chapter 2 palladium catalysts in suzuki cross- coupling reaction
chapter 2 palladium catalysts in suzuki cross- coupling reaction
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NaO 3S<br />
15<br />
P<br />
NaO 3S<br />
P<br />
CH 2COONa<br />
SO 3Na<br />
Me 3N<br />
17 18<br />
Figure 3.2. The water soluble phosph<strong>in</strong>e derivatives used <strong>in</strong> Suzuki <strong>reaction</strong>s<br />
P<br />
P<br />
16<br />
SO 3Na<br />
Sulfonated triphenylphosph<strong>in</strong>es 15 and 16 (TPPTS and TPPMS respectively) are<br />
the most commonly used as water-soluble ligands (Figure 3.2), with which <strong>palladium</strong><br />
goes <strong>in</strong>to aqueous phase and catalytic <strong>reaction</strong> proceeds therefore <strong>in</strong> water (Genet and<br />
Saignac 1999).<br />
Dupuis et al. reported the Suzuki <strong>cross</strong>-coupl<strong>in</strong>g <strong>reaction</strong>s between aryl<br />
bromides and arylboronic acids us<strong>in</strong>g a water soluble Pd(0)/TPPTS catalyst under mild<br />
conditions (Figure 3.3) (Dupuis et al. 2001).<br />
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