Kompendium 2020 Forschung & Klinik
Das Kompendium 2020 der Universitätsklinik für Orthopädie und Unfallchirurgie von MedUni Wien und AKH Wien (o. Univ.-Prof. R. Windhager) stellt einen umfassenden Überblick über die medizinsichen Leistungen und auch die umfangreichen Forschungsfelder dar. Die Veröffentlichungen zeigen die klinische Relevanz und innovative Ansätze der einzelnen Forschungsrichtungen. Herausgeber: Universitätsklinik für Orthopädie und Unfallchirurgie MedUni Wien und AKH Wien Prof. Dr. R. Windhager ISBN 978-3-200-07715-7
Das Kompendium 2020 der Universitätsklinik für Orthopädie und Unfallchirurgie von MedUni Wien und AKH Wien (o. Univ.-Prof. R. Windhager) stellt einen umfassenden Überblick über die medizinsichen Leistungen und auch die umfangreichen Forschungsfelder dar. Die Veröffentlichungen zeigen die klinische Relevanz und innovative Ansätze der einzelnen Forschungsrichtungen.
Herausgeber: Universitätsklinik für Orthopädie und Unfallchirurgie
MedUni Wien und AKH Wien
Prof. Dr. R. Windhager
ISBN 978-3-200-07715-7
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TOP-Studien<br />
48<br />
Figure 2. Histological sections of regenerated<br />
articular cartilage in the MACT group stained with<br />
safranin O at the 12-month follow-up. Shown is<br />
the center of the regenerated area at 2 magnifications.<br />
Blood vessels crossing the tidemark<br />
are marked with arrows, and the chondrocyte<br />
arrangement in the deep zone of cartilage is<br />
presented at a higher magnification. Scale bar:<br />
200 µm (100x), 50 µm (400x).<br />
rial revealed only a slight reduction in staining in MACT and SPONGIO groups<br />
compared to healthy cartilage tissue. In contrast, the MATRIX group showed<br />
strongly reduced staining. The tidemark was broken by blood vessels in all regeneration<br />
groups. Chondrocytes arranged in columns in the central defect area<br />
of the MACT group, suggesting the formation of hyaline cartilage (Figure 2).<br />
In summary, the analysis of the histological evaluation of the 12-month<br />
results showed significant superiority of the MACT and SPONGIO groups<br />
compared to the MATRIX group.<br />
Conclusion<br />
Early OA was treated successfully in a large animal model, with the MACT group<br />
showing the best regeneration after 4 months, persisting until 12 months with<br />
even further improvement during this time. The good results of the SPONGIO<br />
group can be attributed to the use of fibrin glue which was used to stop the<br />
bleeding and standardize the model, and which might have also acted as a<br />
matrix for cells. The poor results of the MATRIX group could be explained by the<br />
sealing of the cancellous bone with flat fibrin glue preventing the migration of<br />
stem cells from the bone into the matrix, suggesting implications for clinical<br />
application in terms of matrix fixation. Further studies are needed to assess<br />
whether these results can be directly transferred to the human knee joint.<br />
Assoz. Prof. Priv.-Doz. Mag. Dr. Stefan Toegel<br />
References:<br />
Author:<br />
Stefan Toegel is head of the<br />
„Karl Chiari Lab for Orthopaedic<br />
Biology“. In 2015, he became an<br />
Associate Professor at the Medical<br />
University of Vienna and<br />
obtained his habilitation in Cell<br />
Biology in 2018. The main focus<br />
of his research is on the pathomechanisms<br />
of osteoarthritis.<br />
1 <br />
Schinhan M, Toegel S, Weinmann D, et al. Biological regeneration of articular cartilage in an early<br />
stage of compartmentalized osteoarthritis: 12-month results. Am J Sports Med. <strong>2020</strong>;48:1338–46.<br />
2 <br />
Aldrian S, Zak L, Wondrasch B, et al. Clinical and radiological long- term outcomes after matrixinduced<br />
autologous chondrocyte transplantation: a prospective follow-up at a minimum of 10 years.<br />
Am J Sports Med. 2014;42:2680–2688.<br />
3 <br />
Brittberg M, Lindahl A, Nilsson A, et al. Treatment of deep cartilage defects in the knee with autologous<br />
chondrocyte transplantation. N Engl J Med. 1994;331:889–895.<br />
4 <br />
Brix MO, Stelzeneder D, Chiari C, et al. Treatment of full-thickness chondral defects with Hyalograft<br />
C in the knee: long-term results. Am J Sports Med. 2014;42:1426–1432.<br />
5 <br />
Schinhan M, Gruber M, Dorotka R, et al. Matrix-associated autologous chondrocyte transplantation<br />
in a compartmentalized early stage of osteoarthritis. Osteoarthr Cartilage. 2013;21:217–225.<br />
6 <br />
Ficat RP, Ficat C, Gedeon P, et al. Spongialization: a new treatment for diseased patellae.<br />
Clin Orthop Relat Res. 1979;144: 74–83.