Kompendium 2020 Forschung & Klinik
Das Kompendium 2020 der Universitätsklinik für Orthopädie und Unfallchirurgie von MedUni Wien und AKH Wien (o. Univ.-Prof. R. Windhager) stellt einen umfassenden Überblick über die medizinsichen Leistungen und auch die umfangreichen Forschungsfelder dar. Die Veröffentlichungen zeigen die klinische Relevanz und innovative Ansätze der einzelnen Forschungsrichtungen. Herausgeber: Universitätsklinik für Orthopädie und Unfallchirurgie MedUni Wien und AKH Wien Prof. Dr. R. Windhager ISBN 978-3-200-07715-7
Das Kompendium 2020 der Universitätsklinik für Orthopädie und Unfallchirurgie von MedUni Wien und AKH Wien (o. Univ.-Prof. R. Windhager) stellt einen umfassenden Überblick über die medizinsichen Leistungen und auch die umfangreichen Forschungsfelder dar. Die Veröffentlichungen zeigen die klinische Relevanz und innovative Ansätze der einzelnen Forschungsrichtungen.
Herausgeber: Universitätsklinik für Orthopädie und Unfallchirurgie
MedUni Wien und AKH Wien
Prof. Dr. R. Windhager
ISBN 978-3-200-07715-7
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
TOP-Studien<br />
36<br />
Figure 2: X-ray images of isolated defect areas<br />
from 2 patients treated with autologous bone<br />
graft substitute (ABGS) or placebo (PBO) from day<br />
1 to month 24. Black arrows shown for the defect<br />
area at month 18 indicate more pronounced BMD<br />
on X-rays of a PBO-treated patient compared with<br />
ABGS. However, at 12 months, still there is a gap<br />
in zone 4 (Z4) for both groups as shown on X-ray<br />
images. At month 24, in the medial site of the gap<br />
for both groups, an incomplete cortical-periosteal<br />
surface restoration after plate removal is indicated<br />
(yellow arrows).<br />
Our Patients<br />
Patients were followed for 0 to 24 months by clinical examination (safety),<br />
computed tomography (CT), and serial radiographic analyses (efficacy) 3 .<br />
The results showed no detectable anti-rhBMP6 antibodies in the blood of<br />
any of the 20 patients at 14 weeks after implantation. During the following<br />
24 months no serious adverse reactions were recorded. The CT scans from<br />
defects of patients treated with rhBMP6/ABC showed an accelerated bone<br />
healing compared with placebo at 9 weeks (47.8 ± 24.1 versus 22.2 ± 12.3<br />
mg/cm 3 ; p = 0.008) and at 14 weeks (89.7 ± 29.1 versus 53.6 ± 21.9 mg/cm 3 ;<br />
p = 0.006) follow-up (Figure 1). Radiographic analyses at weeks 6 and 24 and<br />
months 12 and 24 suggested the advanced bone formation and remodeling<br />
in rhBMP6/ABC-treated patients (Figure 2).<br />
Conclusion<br />
We were able to show that rhBMP6/ABC at a dose of 100 μg/mL accelerates<br />
bone healing in patients undergoing HTO without serious adverse events<br />
and with good tolerability compared with placebo alone. For the first time,<br />
a BMP-based osteogenic implant was examined against a placebo for bone<br />
healing efficacy in the trabecular bone surface, using an objective bone<br />
mineral density measurement system.<br />
ao. Univ.-Prof. in Dr. in Catharina Chiari, MSc<br />
Author:<br />
Catharina Chiari is head of the<br />
Pediatric Orthopedic Team.<br />
Additionally, she has a strong<br />
interest in joint preservation<br />
and regenerative medicine.<br />
Currently she is the president<br />
elect of the Austrian Orthopedic<br />
Society (ÖGO).<br />
References:<br />
1<br />
Vukicevic S, Sampath TK. Bone morphogenetic proteins: systems biology regulators. 1st ed. New<br />
York: Springer International Publishing; 2017.<br />
2<br />
Grgurevic L, Oppermann H, Pecin M, Erjavec I, Capak H, Pauk M, Karlovic S, Kufner V, Lipar M,<br />
Bubic Spoljar J, Bordukalo-Niksic T, Maticic D, Peric M, Windhager R, Sampath TK, Vukicevic S.<br />
Recombinant human bone morphogenetic protein 6 delivered within autologous blood coagulum<br />
restores critical size segmental defects of ulna in rabbits. JBMR Plus. 2019;3(5):e10085.<br />
3<br />
Nemecek E, Chiari C, Valentinitsch A, Kainberger F, Hobusch G, Kolb A, Hirtler L, Trost C, Vukicevic<br />
S, Windhager R. Analysis and quantification of bone healing after open wedge high tibial osteotomy.<br />
Wien Klein Wochenschr. 2019;131(23–24):587–98.