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IDSA Guidelines2Per 2017 Infectious Disease Society of America (IDSA) guidelines, for patients withdiarrhea that persists ≥ 14 days, consider parasitic pathogens 1Clinical presentation of chronic diarrhea may be associated with the following pathogens 1 :Cryptosporidium spp., Giardia lamblia, Cyclospora caytanensis † , Cystoisospora belli † , and Entamoeba histolytica ††Nitazoxanide is not indicated for diarrhea caused by these parasitesConsiderations when evaluating patientswith infectious diarrhea 1• International Travel• Immunocompromised Hosts• Foodborne/Waterborne Vectors• Animal Exposure (Zoonoses)• Antimicrobial Association• Certain Sexual Practices• Long-Term Care Facilities• Child Care Facilities• Healthcare Associated*IndicationsALINIA ® for Oral Suspension (patients 1 year of age and older) and ALINIA Tablets (patients 12 years and older)are indicated for the treatment of diarrhea caused by Giardia lamblia or Cryptosporidium parvum.Limitations of Use: ALINIA for Oral Suspension and ALINIA Tablets have not been shown to be effective for thetreatment of diarrhea caused by Cryptosporidium parvum in HIV-infected or immunodeficient patients.Important Safety Information• ALINIA Tablets and ALINIA for Oral Suspension are contraindicated in patients with a prior hypersensitivityto nitazoxanide or any other ingredient in the formulations.
AGA Clinical Guidelines3In 2019 guidelines, the American Gastroenterology Association (AGA) stronglyrecommends: patients with chronic diarrhea should be tested for Giardia 2Summary of Recommendations on the Laboratory Evaluation of Functional Diarrheaand Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) † in Adults 2StatementrecommendationRecommendation 1: In patients presenting with chronic diarrhea, the AGA suggests the use of either fecalcalprotectin or fecal lactoferrin to screen for IBDRecommendation 2: In patients presenting with chronic diarrhea, the AGA suggests against the use of ESR or CRPto screen for IBDStrength ofrecommendationConditionalConditionalQuality of evidenceLowLowRecommendation 3: In patients presenting with chronic diarrhea, the AGA recommends testing for Giardia Strong HighRecommendation 4: In patients presenting with chronic diarrhea with no travel history to or recent immigrationfrom high-risk areas, the AGA suggests against testing stools for ova and parasites (other than Giardia)Recommendation 5: In patients presenting with chronic diarrhea, the AGA recommends testing for celiac diseasewith IgA-tTG and a second test to detect celiac disease in the setting of IgA deficiencyConditionalStrongLowModerateRecommendation 6: In patients presenting with chronic diarrhea, the AGA suggests testing for bile acid diarrhea Conditional LowRecommendation 7: In patients presenting with chronic diarrhea, the AGA makes no recommendation for the useof currently available serologic tests for diagnosis of IBS†Nitazoxanide is not indicated for diarrhea caused by IBD, IBS, or IBS-DNoneKnowledge gap*IndicationsALINIA ® for Oral Suspension (patients 1 year of age and older) and ALINIA Tablets (patients 12 years and older)are indicated for the treatment of diarrhea caused by Giardia lamblia or Cryptosporidium parvum.Limitations of Use: ALINIA for Oral Suspension and ALINIA Tablets have not been shown to be effective for thetreatment of diarrhea caused by Cryptosporidium parvum in HIV-infected or immunodeficient patients.Important Safety Information• ALINIA Tablets and ALINIA for Oral Suspension are contraindicated in patients with a prior hypersensitivityto nitazoxanide or any other ingredient in the formulations.
Page 1: When diarrhea persists more than 14
Page 5 and 6: About Giardiasis5In the U.S., Giard
Page 7 and 8: ALINIA ® Tablets Clinical Study De
Page 9 and 10: ALINIA ® Tablets Efficacy9ALINIA T
Page 11 and 12: ALINIA ® OS Head-to-Head Data11ALI
Page 13 and 14: ALINIA ® Safety Profile13Most Comm
Page 15 and 16: ALINIA ® Patient Savings15With the

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