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How & Where ALINIA ® Works 12How ALINIA works• ALINIA is the first in class and only FDA-approved thiazolide• The antiprotozoal activity of ALINIA is believed to be due to interference withPFOR enzyme-dependent electron transfer reaction, which is essential toanaerobic energy metabolism. This may not be the only pathway by whichnitazoxanide exhibits antiprotozoal activity 13• Nitazoxanide is absorbed through the intestine and rapidly converted to theactive metabolite, tizoxanide, circulating in the blood 13Where ALINIA works• Approximately 2⁄3 of the oral dose of nitazoxanide is excreted in the fecesand 1⁄3 in the urine 13• ALINIA treats diarrhea caused by an intracellular pathogen (Cryptosporidiumparvum) and a lumenal anaerobic pathogen (Giardia lamblia) 13*IndicationsALINIA ® for Oral Suspension (patients 1 year of age and older) and ALINIA Tablets (patients 12 years and older)are indicated for the treatment of diarrhea caused by Giardia lamblia or Cryptosporidium parvum.Limitations of Use: ALINIA for Oral Suspension and ALINIA Tablets have not been shown to be effective for thetreatment of diarrhea caused by Cryptosporidium parvum in HIV-infected or immunodeficient patients.Important Safety Information• ALINIA Tablets and ALINIA for Oral Suspension are contraindicated in patients with a prior hypersensitivityto nitazoxanide or any other ingredient in the formulations.
ALINIA ® Safety Profile13Most Common Adverse Reactions≥2% of Patients †Abdominal painHeadacheChromaturiaNausea†In pooled controlled clinical trials involving 536 HIV-uninfected subjects treated with ALINIA tablets or ALINIA for oral suspension 14• Adverse events similar to placebo in clinical trials using the recommended dose 14• Less than 1% of patients discontinued in clinical trials due to adverse events 14• No significant inhibitory effect on cytochrome P450 enzymes 13*IndicationsALINIA ® for Oral Suspension (patients 1 year of age and older) and ALINIA Tablets (patients 12 years and older)are indicated for the treatment of diarrhea caused by Giardia lamblia or Cryptosporidium parvum.Limitations of Use: ALINIA for Oral Suspension and ALINIA Tablets have not been shown to be effective for thetreatment of diarrhea caused by Cryptosporidium parvum in HIV-infected or immunodeficient patients.Important Safety Information• ALINIA Tablets and ALINIA for Oral Suspension are contraindicated in patients with a prior hypersensitivityto nitazoxanide or any other ingredient in the formulations.
Page 1 and 2: When diarrhea persists more than 14
Page 3 and 4: AGA Clinical Guidelines3In 2019 gui
Page 5 and 6: About Giardiasis5In the U.S., Giard
Page 7 and 8: ALINIA ® Tablets Clinical Study De
Page 9 and 10: ALINIA ® Tablets Efficacy9ALINIA T
Page 11: ALINIA ® OS Head-to-Head Data11ALI
Page 15 and 16: ALINIA ® Patient Savings15With the

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