3. FOOD ChEMISTRy & bIOTEChNOLOGy 3.1. Lectures

Chem. Listy, 102, s265–s1311 (2008) Food Chemistry & Biotechnology
(a) (b)
Fig. 1. Effect of the chronic inflammation of human pancreas on lipid peroxidation expressed as MDA concentration (a) and 4-HNE
concentration (b); values are the mean ± S.E.M. * Symbol shows significant difference compared to the control, † symbol shows significant
difference between the 1 st and 2 nd blood collection
However, the levels of 4-HnE in the 2 nd blood collection
(mean 0.19 ± S.E.M. 0.01 µmol dm –3 ) were only slightly elevated
in comparison with healthy controls. The concentration
trend of 4-HnE is not correlated with MDA between the
1 st and 2 nd blood collection.
Conclusions
In the present study, we demonstrated that the chronic
inflammation in pancreas is accompanied with an increased
concentration of secondary products of lipid peroxidation
as MDA and 4-HnE in blood plasma. This observation is in
agreement with published studies of other authors 3,4 .
In contrast with 4-HnE, the concentration of MDA in
plasma increased gradually during the followed time period.
It can be suggested that MDA rather then 4-HnE could be a
good biomarker 5,6,7 for monitoring of oxidative stress in patients
with chronic pancreatitis and a progress of the disease.
To confirm this suggestion, these patients will be examined
periodically in the consequent two years.
This study was conducted under the research plan
AVOZ50040507 and supported by grant NR 9295-3 (Internal
Grant Agency of Ministry of Health of The Czech Republic).
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