Womb as Paradise Lost

86
Womb as Paradise Lost – Foetal Programming
Thetic Part 1 – Philosophical Introduction
This cortical strip has projections to the anterior striatum which projects to the
globus pallidus to the anterior dorsal thalamus back to the cortical strip. All of
these regions are also involved in syntax and speech learning. 66
3.5.1 Genetic Applications to Humans
In addition to the similarities in the neurobiological circuits necessary for
vocalizations between animal vocal learners and humans, there are also a
few genetic similarities. The most prominent of these genetic links are the
FOXP1 and FOXP2 genes, which code for forkhead box (FOX) proteins P1
and P2 respectively. FOXP1 and FOXP2 are transcription factors which
play a role in the development and maturation of the lungs, heart and
brain, 67 and are also highly expressed in brain regions of the vocal learning
pathway, including the basal ganglia and the frontal cortex. 68
In these regions (i.e. the basal ganglia and frontal cortex), FOXP1 and
FOXP2 are thought to be essential for brain maturation and development of
speech and language. 69
Researchers have found that patterns of expression of FOXP1 and FOXP2 are
amazingly similar in the human foetal brain and the songbirds. 70
In humans, FOXP2 is highly expressed in the basal ganglia, frontal cortex, and
insular cortex, all thought to be important nodes in the human vocal pathway.
66 Jarvis, ED (2007). "Neural systems for vocal learning in birds and humans: a synopsis". Journal of Ornithology 148
(1): 35–44. An important item according to the research of MDF-syndrome and Fetal Programming.
67 Pariani, MJ; Spenser, A, Graham Jr, JM, Rimoin, DL (2009). "A 785 kb deletion of 3p14.1p13 including the FOXP1
gene, associated with speech delay, contractures, hypertonia and blepharophimosis". European Journal of Medical Genetics
52 (2-3): 123–127.
68 Vargha-Kahadem, F; Gadian, DG; Copp, A; Mortimer, M (2005). "FOXP2 and the neuroanatomy of speech and language".
Nature Reviews Neuroscience 6 (2): 131–138.
69 Vargha-Kahadem, F; Gadian, DG; Copp, A; Mortimer, M (2005). "FOXP2 and the neuroanatomy of speech and language".
Nature Reviews Neuroscience 6 (2): 131–138.
70 Vargha-Kahadem, F; Gadian, DG; Copp, A; Mortimer, M (2005) op.cit.