Womb as Paradise Lost

Womb as Paradise Lost – Foetal Programming
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Practical Part – Mindlink sysrtem: “Concluding Remarks”
of embryonically active promoters, namely CpG islands 343 , so that they remain
potentially active throughout development and adulthood. (...) Thus, CpG islands
that are silenced by other mechanisms during embryogenesis would acquire dense
methylation leading to irreversible silencing. When, however, the density of
methylated CpG’s is low, as it is in most of the genome, repression is likely to be
weak and may be overcome by the presence of strong activators. 344
In the cadre of MFD-syndrome we have to research the correlation between prenatal
emotional state and maternal cortisol with methylation state of NR3C1. 345
Here the genome and the epigenome, together with the vital-emotive and/or physical
disorders of the pregnant woman, has received in-formation that gives form
to the potentiality of the “unknown” content. This form is phenomenologically
343 CpG islands (or CG islands) are regions with a high frequency of CpG sites, though objective definitions for CpG
islands are limited. The usual formal definition of a CpG island is a region with at least 200 bp, and a GC percentage that
is greater than 50 % ..., Wikipedia.
344 Shobha Vasude, Emre Seli, and Joan A. Steitz Metazoan oocyte and early embryo development program: a progression
through translation regulatory cascades Genes Development. January 15, 2006 20: 138-146
345 The name glucocorticoid (glucose + cortex + steroid) derives from its role in the regulation of the metabolism of glucose,
its synthesis in the adrenal cortex, and its steroidal structure. A less common synonym is glucocorticosteroid.