[libribook.com] Traumatic Scar Tissue Management 1st Edition

are covered in greater detail in Chapter 6. As burn trauma often impacts larger
surface areas, Chapter 6 will also discuss area of damage and amount of tissue
loss considerations in greater detail.
NP/CM Impact Outcome
Substance
P
CGRP
Elevated levels linked to excessive inflammation and subsequent
sequelae; including fibroblasts proliferation and increased histamine
release by mast cells
Elevated levels linked to sensory symptoms associated with wound
healing and chronic inflammation
Increased incidence of:
• pathophysiological scars
• pruritus and other
sensory disturbances
(e.g. hyperalgesia and
allodynia)
• heightened pain
sensation
Increased incidence of:
• pruritus
• heightened pain
sensation
• pain
translation/development
of chronic/persistent
pain
NGF Altered levels linked to disruption of normal wound healing processes Adverse impact on:
• neuron
development/survival
• inflammatory processes
Various
NPs,
histamine
and
kinins
Elevated levels linked to exaggeration of neurogenic inflammation,
increased receptor hypersensitivity and aberrant re-innervation;
including, density aberrancies and increased concentration of receptors
sensitive to certain stimulants, such as Substance P and CGRP, that
drive various outcomes
Increased incidence of:
• pathophysiological scars
• aberrant reinnervation/nerve
density
Increased incidence of:
• pathophysiological scars
• pruritus and other
sensory disturbances
• pain
translation/development
of chronic/persistent
pain
• small nerve fiber
neuropathy