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[libribook.com] Traumatic Scar Tissue Management 1st Edition

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Clinical Consideration

Because therapeutic agents that target the TGF-β signaling pathway have

been shown to improve wound healing and reduce scarring (Finnson et al.

2013), targeting the TGF-β signaling pathway represents a viable strategy

for improving wound healing and reducing pathological scarring (Finnson

et al. 2013). Transforming growth factor beta-1 (TGF-β1) activation is – in

part – influenced by tissue tension (Wipff & Hinz 2009, Meyer-ter-Vehn et

al. 2011). It is suggested that the manual manipulation of fascia has the

potential to change the cell-matrix tension state (i.e. restoration of tensional

homeostasis) and possibly influence localized TGF-β1 activity (Grinell

2008).

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