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[libribook.com] Traumatic Scar Tissue Management 1st Edition

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Clinical Consideration

Following persistent inflammation in skeletal muscle, an increase in free

nerve-ending fiber density in the perimysium can occur within 12 days.

The mechanism proposed suggests NGF as the contributing factor to the

increase in substance P production in the dorsal root ganglion. This

illustrates the rapidity with which the PNS can become ‘efficient’ at pain

transmission and supports the importance of timely modulation of the early

immune response (Reinert et al. 1998, Waters-Banker et al. 2014).

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