[libribook.com] Traumatic Scar Tissue Management 1st Edition

Clinical Consideration
Transforming growth factor beta-1 (TGF-β1) is known to stimulate
collagen synthesis and proliferation. Collagen is the predominant fiber
found in fascia and the predominant type of fiber laid-down during softtissue
repair/remodeling – more on this in Chapter 5.
MFBs can contract in a smooth muscle-like manner providing fascia with
contractile capabilities independent of muscle contraction (Spector 2002, Schleip
et al. 2005, Schleip et al. 2006).
MFB contraction plays a major role in wound healing/remodeling, pathological
fascial contractures and fibrosis (e.g. Dupuytren disease, plantar fibromatosis,
frozen shoulder, ChLBP and abnormal scar formation) (Gabbiani 2003,
Langevin et al. 2009). Therefore higher than normal concentrations of MFBs are
typically present in injured or traumatized fascia.