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[libribook.com] Traumatic Scar Tissue Management 1st Edition

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Clinical Consideration

Manual therapy techniques treat the fascial layers by altering density,

tonus, viscosity and the arrangement of fascia (Findley et al. 2012).

Myofibroblasts (MFBs): differentiation of fibroblasts into MFBs is triggered in

response to mechanical strain/tensional loading and certain cytokines (e.g.

transforming growth factor beta-1; TGF-β1). MFBs play an important role in

inflammation, remodeling and fibrosis (Cathie 1974, Powell et al. 1999,

Tomasek et al. 2002, Hinz & Gabbiani 2003, Schleip et al. 2007, Nekouzadeh et

al. 2008, Hinz 2013).

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