[libribook.com] Traumatic Scar Tissue Management 1st Edition

Histology
Fascia comprises:
• ECM (covered previously)
• Cells
• Fibrous proteins.
Cells
The most prominent cellular components of fascia include:
• Mast cells and macrophages
• Adipocytes
• Fibroblasts.
Mast cells and macrophages play a role in wound repair and immune
response.
Adipocytes play a role in heat preservation, storage, protection from physical
trauma and also serve as a ‘spacer’ separating adjacent layers of fascia (Stecco
et al. 2008).
Fibroblasts, the predominant cell type, are highly adaptable and noted for their
ability to:
– remodel in response to mechanical strain
– produce biochemical responses, and
– differentiate into various cell types (e.g. myofibroblasts) (Eagen et al.
2007, Mammoto & Ingber 2009, Stecco et al. 2009, Meltzer et al. 2009).
Fibroblasts synthesize the components of the ECM and play a significant role in
soft-tissue remodeling.