[libribook.com] Traumatic Scar Tissue Management 1st Edition

16.06.2020 Views

Clinical ConsiderationIt is suggested that alterations in HA amount and organization may play arole in tissue changes (e.g. tissue softening and improved slide/glide)following fascial manipulations (Evanko & Wight 1999).

Clinical ConsiderationHA and its fragments may play crucial roles in the skin wound-healingprocess by modulating the expression of fibroblast genes involved inremodeling and repair of ECM (David-Raoudi et al. 2008).Collectively the ECM defines the shape and form of our cells. It provides aframework to which the cells can adhere, move about in and communicatethrough. The ECM creates a medium by which appropriate balance can bemaintained between porosity, hydration and ionic environment, thus allowingnutrients and metabolites to diffuse freely into and out of our cells. The ECMacts as an immune barrier. It is also a repository for metabolites and toxins, andfor storing fat.The ECM plays an important role in wound healing and repair. It serves as arepository for signaling molecules and mediates signals from other cells topromote cell proliferation and differentiation.The ECM is responsive to mechanical strain and tensional loading (tissuedeformation). Mechanical forces exert influence on the tissue structural elements(microfilaments) and the molecular composition of the ECM (Benjamin &Ralphs 1998, Milz et al. 2005). Strain type, degree, direction and duration caninfluence ECM composition and impact fibroblast functions that guide healingand adaptation responses (Purslow 2002, Ingber 2003, Standley & Meltzer 2008,Stecco et al. 2009, Blechschmidt & Gasser 2012). The clinical relevance of thisfeature of the ECM will be noted throughout this book.One of the mechanisms by which cells sense changes in mechanicalstrain/tensional load is via specialized (matrix adhered) transmembrane receptors(integrins). Integrins play a role in defining cellular shape, mobility, regulatingthe cell cycle and mediating cell-to-cell and cell-to-ECM signals. Via integrins,mechanical stimulus can evoke a biochemical response, which, in turn, cantrigger a variety of cellular responses and activities. Conversion of mechanicalstimulus into biochemical response is called mechanotransduction. The integrin–mechanotransduction communication system works much faster than neurally

Clinical Consideration

It is suggested that alterations in HA amount and organization may play a

role in tissue changes (e.g. tissue softening and improved slide/glide)

following fascial manipulations (Evanko & Wight 1999).

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