[libribook.com] Traumatic Scar Tissue Management 1st Edition

16.06.2020 Views

Pathophysiological ConsiderationAbnormal or pathological cross-links, instigated by variouspathophysiological circumstance (e.g. diminished GS), can adverselyimpact tissue mobility and lead to tissue contracture and shortening (Vanden Berg 2010, 2012). Changes to the ECM (adhesions betweenmicrofilaments, i.e. pathological crosslinks) are seen in scarred fascia(Kozma et al. 2005, Chirasatitsin & Engler 2010).

Ground substanceGround substance (GS), the amorphous gel-like component of the ECM, is animportant metabolic interface that fills the space between cells and fibers. GSinfluences tissue development and cellular migration, proliferation, shape andmetabolic functions.Constituents within the GS (e.g. GAGs and PGs) perform a variety of functionsthat can influence tissue development and cellular migration, proliferation, shapeand metabolic functions (Van den Berg 2012). One important feature of theseconstituents is their ability to attract and bind water, which factors significantlyinto fascia’s viscoelastic properties and in lubrication, thereby reducing frictionbetween moving or sliding fibers, tissues and layers.

Ground substance

Ground substance (GS), the amorphous gel-like component of the ECM, is an

important metabolic interface that fills the space between cells and fibers. GS

influences tissue development and cellular migration, proliferation, shape and

metabolic functions.

Constituents within the GS (e.g. GAGs and PGs) perform a variety of functions

that can influence tissue development and cellular migration, proliferation, shape

and metabolic functions (Van den Berg 2012). One important feature of these

constituents is their ability to attract and bind water, which factors significantly

into fascia’s viscoelastic properties and in lubrication, thereby reducing friction

between moving or sliding fibers, tissues and layers.

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