Open Access e-Journal Cardiometry No.16 May 2020

EDITORIAL
The performance of the cardiovascular system
and the immunity: new philosophy in
health care
Our organism works as an integrated unit. The performance
of the cardiovascular system is linked with
all levels of immunity. Any changes in an external and/
or internal environment of an organism, including the
presence of latent infectious and toxic processes initiated
by pathogens of bacterial, viral, fungal and parasitic
origin, affecting the organs and the systems therein, that
may result in chronic diseases, find reflection in hemodynamics.
The most advanced theory of hemodynamics
is covered by our journal in details, and the present
issue is not an exception. But we would like to note
some practical recommendations on maintaining the
normal immunity in healthy subjects: the recommendations
have been prepared by our authors, researchers
having extensive experience in theory and practice.
1. Adaptation reactions in a human organism
Professor A.I. Shikhlyarova presents her statement
as follows:
Relationships between the cardiovascular system
state and the adaptation reactions (AR), including
the coagulation mechanisms, have been evidenced by
many research works; that has found successful applications
to many techniques in practice.
First of all, each AR has its own specific profile in relation
to the coagulation and anticoagulation systems.
Under stress, especially in the phase of alarm, there
is an increase in the coagulation potential: the R reaction
time is shortened by half, and as a result the total
time of coagulation T is reduced. In other words, the
activity of the coagulation system grows.
With the reaction of training the diametrically opposite
events occur: hypocoagulation is observed: the C
clotting time becomes longer by more than twice and,
despite the fact that the R reaction time remains the
same, prolongation R + K is observed that indicates an
increase in activity of the anticoagulation system. At the
same time, a decrease in fibrinogen constants is found.
With development of the calm activation reaction,
especially its primary phase, the functions of the coagulation
and anticoagulation systems are well balanced.
There are differences between the calm (CA) and elevated
activation (EA) according to the changes in the
blood coagulation. In case of EA, a moderate hypocoagulation
develops. The R reaction time becomes longer;
the anticoagulation system (R + K) is activated,
but moderately, not as pronounced as under the reaction
of training.
Besides, when investigating the brain activity (EEG),
also some rheological parameters characterizing the
magnitude of systolic supply, the microcirculatory bed
vascular tone, the diastolic index, the vascular elasticity
have been studied that characterizes the state of the elastic
properties of large-size arteries and other parameters
at various adaptation reactions. There are some descriptions
of these changes outlined by my monograph “Adaptation
reactions and activation therapy”, 2002, page 49.
In Journal Cardiometry, Issue 15, you can find my
paper treating some aspects of practical applications
of AR. It offers practical recommendations on the AR
type correction using conventional biostimulants.
It follows that the nonspecific basis for the cardiovascular
system state, as one of the essential integral
component of the organism life maintenance, is an archetype
of that adaptation reaction, which performs
differentiated implementation of the homeostasis regulation
mechanisms under variable functional loads.
2. Increase in nonspecific resistance and
immune protection of the organism
Professor E.I. Maevsky writes the following:
Succinate-based food additives: Miodon (developed
by ITEB RAS, Research Center “Mioran” Ltd.) and its
analogues Signalom Active and Signalom Pro Sport,
produced in Canada, in addition to their capability to
intensify the performance, accelerate the recovery rate
of the human organism from fatigue and asthenic conditions,
demonstrate their pronounced immunotropic
effect, increase the nonspecific resistance and the immune
protection in a human organism.
The mechanism of the action of these agents includes
four main factors:
1. The primary component of this sort of food additives
is succinate at doses of 10-4-10-5 М which activates
cell receptor SUCNR1, responsible for the mobilization
of the proper functions in various tissues, and
especially, the hypothalamus, the heart, the kidney, the
liver and the main elements of innate immunity: dendritic
cells, macrophages, T and B lymphocytes.
2. The same signal doses of succinate stabilize intracellular
factor HIF1α, which induces formation of the
HIF dimer initiating transcription of genes responsible
for the formation of the adaptation to hypoxia,
8 | Cardiometry | Issue 16. May 2020