Calcium Channel
Calcium is the oldest and most widely used signaling substance in the cell and is involved in the regulation of almost all biological functions of the body, such as cardiac and muscle contraction, neuronal transmission, learning and memory, embryogenesis and development, cell proliferation and apoptosis, cell division and differentiation, cell energy metabolism, protein phosphorylation and dephosphorylation modification, and gene expression and regulation. Calcium is the oldest and most widely used signaling substance in the cell and is involved in the regulation of almost all biological functions of the body, such as cardiac and muscle contraction, neuronal transmission, learning and memory, embryogenesis and development, cell proliferation and apoptosis, cell division and differentiation, cell energy metabolism, protein phosphorylation and dephosphorylation modification, and gene expression and regulation.
Calcium ChannelCalcium is the oldest and most widely used signaling substance in the cell and isinvolved in the regulation of almost all biological functions of the body, such ascardiac and muscle contraction, neuronal transmission, learning and memory,embryogenesis and development, cell proliferation and apoptosis, cell division anddifferentiation, cell energy metabolism, protein phosphorylation anddephosphorylation modification, and gene expression and regulation. Thecytoplasmic free calcium ion concentration of mammalian cells is generallycontrolled at 100-200 nmol/L.The steep but tightly controlled concentration gradient of calcium ions between thecell membrane and the cytoplasm and organelles is maintained and dynamicallyregulated according to the needs of the cells. It relies on a variety of ion channels, ionpumps, and transporters to work together. Although different cells have differentspecific mechanisms, the molecules involved in calcium channel is including cellmembranes and organelle membrane ion channels (mediating calcium ions into thecytoplasm), transporters of cell membranes and organelle membranes (includingprimary active transport and secondary transport), cytoplasmic and organellecalcium buffer protein (combined storage of calcium ions), etc. Any abnormality inthe links may cause instability of calcium homeostasis and cause disease. Elucidationof the regulation mechanism of calcium channel reveals one of the basic links ofcalcium homeostasis and the regulation of life processes.
Calcium Channel
Calcium is the oldest and most widely used signaling substance in the cell and is
involved in the regulation of almost all biological functions of the body, such as
cardiac and muscle contraction, neuronal transmission, learning and memory,
embryogenesis and development, cell proliferation and apoptosis, cell division and
differentiation, cell energy metabolism, protein phosphorylation and
dephosphorylation modification, and gene expression and regulation. The
cytoplasmic free calcium ion concentration of mammalian cells is generally
controlled at 100-200 nmol/L.
The steep but tightly controlled concentration gradient of calcium ions between the
cell membrane and the cytoplasm and organelles is maintained and dynamically
regulated according to the needs of the cells. It relies on a variety of ion channels, ion
pumps, and transporters to work together. Although different cells have different
specific mechanisms, the molecules involved in calcium channel is including cell
membranes and organelle membrane ion channels (mediating calcium ions into the
cytoplasm), transporters of cell membranes and organelle membranes (including
primary active transport and secondary transport), cytoplasmic and organelle
calcium buffer protein (combined storage of calcium ions), etc. Any abnormality in
the links may cause instability of calcium homeostasis and cause disease. Elucidation
of the regulation mechanism of calcium channel reveals one of the basic links of
calcium homeostasis and the regulation of life processes.
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