European Patent Bulletin 2012/09 - European Patent Office
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(C07D) II.1(1)<br />

(54) VERBESSERTES VERFAHREN ZUR HER-<br />

STELLUNG VON LETROZOL UND ZWI-<br />

SCHENPRODUKTEN DAVON<br />

AN IMPROVED PROCESS FOR<br />

PREPARATION OF LETROZOLE AND ITS<br />

INTERMEDIATES<br />

PROCÉDÉ PERFECTIONNÉ DE PRÉPARA-<br />

TION DU LÉTROZOLE ET SES INTERMÉ-<br />

DIAIRES<br />

(73) Fresenius Kabi Oncology Limited, B- 310,<br />

Som Datt Chambers - I Bhikaji Cama Place,<br />

New Delhi 110 066, IN<br />

(72) SHRAWAT, Vimal, Kumar, Ghaziabad 201<br />

010, IN<br />

SINGH, Jai, Pal, Ghaziabad 201 010, IN<br />

NAUTIYAL, Rajesh, Prasad, Ghaziabad 201<br />

010, IN<br />

(74) Le Coupanec, Pascale A.M.P., Cabinet Nony<br />

3, rue de Penthièvre, 75008 Paris, FR<br />

C07D 301/10 → (51) C07C 41/03<br />

C07D 307/20 → (51) C11C 3/00<br />

C07D 307/32 → (51) C07C 211/48<br />

C07D 307/60 → (51) C07D 4<strong>09</strong>/12<br />

C07D 3<strong>09</strong>/14 → (51) C07C 211/48<br />

C07D 317/64 → (51) C07C 217/64<br />

C07D 319/12 → (51) C11C 3/00<br />

(51) C07D 333/16 (11) 2 228 372 B1<br />

(25) En (26) En<br />

(21) 10156142.1 (22) 10.03.2010<br />

(84) AT BE BG CH CY CZ DE DK EE ES FI FR GB<br />

GR HR HU IE IS IT LI LT LU LV MC MK MT<br />

NL NO PL PT RO SE SI SK SM TR<br />

(43) 15.<strong>09</strong>.2010<br />

(30) 12.03.20<strong>09</strong> US 402740<br />

05.03.2010 US 718289<br />

(54) Verfahren zur Herstellung von (S)-(+)-N-<br />

Methyl-3-(1-Naphthyloxy)-3-(2-Thienyl)-<br />

Propylamin mittels einer optisch aktiven<br />

Methylhydroxylaminopropanolverbindung<br />

als Zwischenprodukt<br />

Process for Preparing (S)-(+)-N-Methyl-3-<br />

(1-Naphthyloxy)-3-(2-Thienyl-Propylamine<br />

by using Optically Active Methylhydroxylaminopropanol<br />

Compound as an Intermediate<br />

Procédé de préparation de (S)-(+)-N-<br />

Methyl-3-(1-Naphthyloxy)-3-(2-Thienyl-<br />

Propylamine en utilisant un composant<br />

optique actif de Méthylhydroxylaminopropanol<br />

en tant qu'intermédiaire<br />

(73) SCI Pharmatech, Inc., Hai-Hu-Tsun Lu-Chu-<br />

Hsiang, Taoyuan, TW<br />

(72) CHEN, Bo-Feng, Taoyuan, TW<br />

YEH, Jinun-Ban, Taoyuan, TW<br />

WONG, Weichyun, Toayuan, TW<br />

LU, Feng-Ju, Taoyuan, TW<br />

(74) Jones, Helen M.M., Gill Jennings & Every<br />

LLP The Broadgate Tower 20 Primrose<br />

Street, London EC2A 2ES, GB<br />

C07D 401/02 → (51) C07D 211/58<br />

C07D 401/04 → (51) C07D 213/75<br />

C07D 401/06 → (51) C07D 211/58<br />

C07D 401/12 → (51) A01N 43/40<br />

C07D 401/12 → (51) C07D 2<strong>09</strong>/42<br />

C07D 401/12 → (51) C07D 211/58<br />

Europäisches <strong>Patent</strong>blatt<br />

<strong>European</strong> <strong>Patent</strong> <strong>Bulletin</strong><br />

<strong>Bulletin</strong> européen des brevets<br />

C07D 401/12 → (51) C07D 213/75<br />

C07D 401/14 → (51) A61K 31/506<br />

C07D 401/14 → (51) C07D 211/58<br />

C07D 401/14 → (51) C07D 239/90<br />

C07D 401/14 → (51) C<strong>09</strong>B 5/14<br />

(51) C07D 403/04 (11) 2 123 649 B1<br />

A61K 31/404 A61K 31/405<br />

A61P 35/00 A61P 3/10<br />

A61P 7/00 A61P 29/00<br />

A61P 37/00 A61P 9/00<br />

(25) Zh (26) En<br />

(21) 07817351.5 (22) 03.12.2007<br />

(84) AT BE BG CH CY CZ DE DK EE ES FI FR GB<br />

GR HU IE IS IT LI LT LU LV MC MT NL PL<br />

PT RO SE SI SK TR<br />

(43) 25.11.20<strong>09</strong><br />

(86) CN 2007/071161 03.12.2007<br />

(87) WO 2008/067756 2008/24 12.06.2008<br />

(30) 04.12.2006 CN 200610<strong>09</strong>8202<br />

15.12.2006 CN 200610161220<br />

(54) 3-PYRROLO-CYCLOHEXYLEN-2-DIHY-<br />

DROINDOLINONDERIVATE UND ANWEN-<br />

DUNGEN DAVON<br />

3-PYRROLO-CYCLOHEXYLENE-2-<br />

DIHYDRO-INDOLINONE DERIVATIVES<br />

AND USES THEREOF<br />

DÉRIVÉS DE 3-PYRROLO-CYCLOHEXY-<br />

LÈNE-2-DIHYDRO-INDOLINONE ET<br />

UTILISATIONS DE CEUX-CI<br />

(73) Jiangsu Simcere Pharmaceutical R&D Co.,<br />

Ltd., No. 12 Huayuan Road, Nanjing Jiangsu<br />

210042, CN<br />

(72) TANG, Feng c/o JIANGSU SIMCERE PHAR-<br />

MACEUTICAL R&D CO., LTD., Nanjing<br />

Jiangsu 210042, CN<br />

SHEN, Han c/o JIANGSU SIMCERE PHAR-<br />

MACEUTICAL R&D CO., LTD, Nanjing<br />

Jiangsu 210042, CN<br />

JIN, Qiu c/o JIANGSU SIMCERE PHARMA-<br />

CEUTICAL R&D CO., LTD, Nanjing Jiangsu<br />

210042, CN<br />

DING, Lei c/o JIANGSU SIMCERE PHARMA-<br />

CEUTICAL R&D CO., LTD, Nanjing Jiangsu<br />

210042, CN<br />

YANG, Jie c/o JIANGSU SIMCERE PHAR-<br />

MACEUTICAL R&D CO., LTD, Nanjing<br />

Jiangsu 210042, CN<br />

YIN, Xiaojin c/o JIANGSU SIMCERE PHAR-<br />

MACETICAL R&D CO., LTD., Nanjing<br />

Jiangsu 210042, CN<br />

LU, Shiyue c/o JIANGSU SIMCERE PHAR-<br />

MACEUTICAL R&D CO., LTD., Nanjing<br />

Jiangsu 210042, CN<br />

(74) Kramer, Reinhold, Kramer - Barske -<br />

Schmidtchen Landsberger Strasse 300,<br />

80687 München, DE<br />

(51) C07D 403/12 (11) 1 636 208 B1<br />

C07D 417/12 A61K 31/401<br />

A61K 31/4155 A61K 31/425<br />

A61K 31/4965<br />

(25) En (26) En<br />

(21) 04759362.9 (22) <strong>09</strong>.04.2004<br />

(84) AT BE BG CH CY CZ DE DK EE ES FI FR GB<br />

GR HU IE IT LI LU MC NL PL PT RO SE SI<br />

SK TR<br />

AL HR LT LV MK<br />

(43) 22.03.2006<br />

(86) US 2004/011012 <strong>09</strong>.04.2004<br />

(87) WO 2004/<strong>09</strong>2162 2004/44 28.10.2004<br />

(30) 11.04.2003 US 412600<br />

23.10.2003 US 513765 P<br />

658<br />

<strong>Patent</strong>e<br />

<strong>Patent</strong>s<br />

Brevets (<strong>09</strong>/<strong>2012</strong>) 29.02.<strong>2012</strong><br />

(54) INHIBITOREN VON SERINPROTEASEN,<br />

INSBESONDERE HCV-NS3-NS4A-PRO-<br />

TEASE<br />

INHIBITORS OF SERINE PROTEASES,<br />

PARTICULARLY HCV NS3-NS4A<br />

PROTEASE<br />

INHIBITEURS DES SERINE PROTEASES,<br />

EN PARTICULIER DE LA PROTEASE NS3-<br />

NS4A DU VHC<br />

(73) VERTEX PHARMACEUTICALS INCOR-<br />

PORATED, 130 Waverly Street, Cambridge,<br />

MA 02139-4242, US<br />

(72) FARMER, Luc, J., Foxboro, MA 02035, US<br />

PERNI, Robert, P., Marlborough, MA 01752,<br />

US<br />

BHISETTI, Govinda, Rao, Lexington, MA<br />

02421, US<br />

WILSON, Keith, P., La Jolla, CA 92037, US<br />

(74) Burrichter, Arwed Andreas, COHAUSZ &<br />

FLORACK <strong>Patent</strong>- und Rechtsanwälte Partnerschaftsgesellschaft<br />

Bleichstrasse 14,<br />

40211 Düsseldorf, DE<br />

(60) 10178023.7 / 2 332 935<br />

C07D 403/12 → (51) C07D 2<strong>09</strong>/42<br />

C07D 403/12 → (51) C07D 213/75<br />

C07D 403/12 → (51) C07D 239/90<br />

C07D 403/14 → (51) A61K 31/506<br />

C07D 403/14 → (51) C07D 239/90<br />

C07D 405/12 → (51) C07D 2<strong>09</strong>/42<br />

C07D 405/12 → (51) C07D 213/75<br />

C07D 405/14 → (51) C07D 2<strong>09</strong>/42<br />

C07D 407/06 → (51) C11C 3/00<br />

C07D 4<strong>09</strong>/06 → (51) C07D 213/75<br />

(51) C07D 4<strong>09</strong>/12 (11) 2 176 255 B1<br />

C07D 307/60 A61K 31/365<br />

A61K 31/385 A61P 35/00<br />

A61P 29/00 A61P 3/10<br />

A61P 31/00<br />

(25) En (26) En<br />

(21) 08783912.2 (22) 07.08.2008<br />

(84) AT BE BG CH CY CZ DE DK EE ES FI FR GB<br />

GR HR HU IE IS IT LI LT LU LV MC MT NL<br />

NO PL PT RO SE SI SK TR<br />

(43) 21.04.2010<br />

(86) CN 2008/071919 07.08.2008<br />

(87) WO 20<strong>09</strong>/018780 20<strong>09</strong>/07 12.02.20<strong>09</strong><br />

(30) 08.08.2007 CN 200710029644<br />

(54) ANDROGRAPHOLIDDERIVATE UND DE-<br />

REN VERWENDUNG BEI DER HERSTEL-<br />

LUNG VON MEDIKAMENTEN<br />

ANDROGRAPHOLIDE DERIVATIVES AND<br />

USE THEREOF IN MANUFACTURE OF<br />

MEDICAMENTS<br />

DÉRIVÉS D'ANDROGRAPHOLIDE ET<br />

LEUR UTILISATION POUR LA FABRICA-<br />

TION DE MÉDICAMENTS<br />

(73) Panorama Research Inc., 1230 Bordeaux<br />

Drive, Sunnyvale, CA 94089, US<br />

(72) WANG, Yuqiang, Guangdong 510632, CN<br />

JIANG, Xiaojian, Guangdong 510632, CN<br />

JIANG, Jie, Guangdong 510632, CN<br />

ZHANG, Zaijun, Guangdong 510632, CN<br />

YANG, Zhaoqi, Guangdong 510632, CN<br />

YU, Pei, Guangdong 510632, CN<br />

(74) UEXKÜLL & STOLBERG, <strong>Patent</strong>anwälte Beselerstrasse<br />

4, 22607 Hamburg, DE<br />

C07D 4<strong>09</strong>/12 → (51) C07D 211/58

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