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Biologische Systeme und Medizin Poster: Mi., 14:00–16:30 M-P183 Large scale Protein dynamics studied by Neutron Spinecho Spectroscopy Ralf Biehl 1 , Bernd Hoffmann 2 , Michael Monkenbusch 1 , Bela Farago 3 , Rudolf Merkel 2 , Dieter Richter 1 1 Institut für Festkörperforschung, FZJ, Germany – 2 Institut für Schichten und Grenzflächen, FZJ, Germany – 3 Institut Laue-Langevin, Grenoble, France During operation of proteins as universal nanomachines or involved in the transmission and amplification of signals, conformational changes are omnipresent. An intriguing combination of structure and flexibility facilitates their activity. Conformational changes can be triggered by small-amplitude, nanosecond protein domain motion. Understanding how conformational changes are initiated requires the characterization of protein domain motion on these timescales and on length scales comparable to protein dimensions. We present here examinations by Neutron Spinecho Spectroscopy of the internal dynamics of the unfolded globular protein ribonuclease A under thermal stress and the protein alcohol dehydrogenase in equilibrium.
Biologische Systeme und Medizin Poster: Mi., 14:00–16:30 M-P184 Chiral discrimination and structural analysis of RNA by Raman spectroscopy and x-ray crystallography Sarah Bolik 1 , Benjamin Schulz 1 , Michael Ruebhausen 1 , Mathias Kramer 2 , Markus Perbandt 2 , Christian Betzel 2 , V.E. Erdmann 3 , Sven Klussmann 4 1 Insitut für Angewandte Physik, Universität Hamburg – 2 Institut für Biochemie, Univeristät Hamburg – 3 Institut für Biochemie, Freie Universität Berlin – 4 Noxxon Pharma AG, Berlin Amino acids found in living organisms occur almost exclusively as L-enantiomers and nucleic acids as D-enantiomers. The origins of this pervasive homochirality have never been explained satisfactorily. Because there is no obvious biochemical reason for choosing one enantiomer over the other, numerous physical and biochemical mechanisms have been invoked to explain the phenomenon. Chirality is a fundamental aspect of chemical biology, and is of central importance in pharmacology. We have analysed the L- and the D- enantiomer of an RNA molecule with the sequence (r(CUGGGCGG)x r(CCGCCUGG)) by X-ray crystallography and Raman spectroscopy. The combined results of these experiments reveal new insights about the nature of chirality in nucleic acids. X-ray crystallography is a technique in crystallography in which the pattern produced by the diffraction of X-rays through the closely spaced lattice of atoms in a crystal is recorded and then analyzed to reveal the nature of that lattice. Since electrons more or less surround atoms uniformly, it is possible to determine where atoms are located. This generally leads to an understanding of the material and molecular structure of a substance. This technique is widely used in chemistry and biochemistry to determine the structures of inorganic compounds, DNA/RNA, and proteins. X-ray diffraction is commonly carried out using single crystals of a material. Inelastic light scattering can reveal structural changes as well as changes in the electronic structure of the investigated system due to its coupling to electronic matrix elements. We use incident photons around 5 eV, where specific chromophores within the enantiomer exhibit a resonance. Spectra could be described by taking into account oscillation modes of the included bases. These modes are superpositions of modes originating from the different possible vibrations of atoms in the complex structured bases. We find that there is no sign of a structural difference in the spectra of L- and D-RNA. Nevertheless, small changes in the modes between the two forms enable us to calculate a Raman Difference Spectrum (RDS). The RDS is dependent on the incident photon energy. We suggest that electronic configuration between L- and D-RNA is different due to charge transfer effects that modify the electronic structure to which the Raman probe couples. We outline how to use this matrix element effect for the study of bio-organic matter.
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Deutsche Tagung für Forschung mit
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Impressum: Herausgeber: A. Schreyer
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Postersitzung A Mittwoch, 4. Oktobe
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Postersitzung B Donnerstag, 5. Okto
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Allgemeine Hinweise Tagungsort Die
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Plenarvortrag Mi., 10:00-10:30 M-PV
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Index Autoren und ihre Beiträge: u
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Index M-P98, M-P100, M-P101, M-P195
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Index Deák, L. D-P300 Decker, H. M
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Index Gavrila, G. D-P276 Gebhardt,
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Index Homeyer, J. D-P377, D-P389 Ho
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Index Kravtsov, E. D-P231, D-P252 K
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Index Mezei, F. M-P13, M-P22, D-V27
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Index Ponce, M.L. D-P214 Ponkratz,
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Index Stürmer, D. D-P405 Stuermer,
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Index Wochner, P. F-V68 Woiterski,
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