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18<br />

G. Litscher<br />

colleagues [4] did consider the SEF, nor did they<br />

investigate the effects of manual needle acupuncture<br />

and the effects of<strong>Laser</strong>needle@ acupuncture.<br />

We have shown in this study that awake volunteers<br />

subjected to acupressure at Yintang can have<br />

similar BIS and SEF values to anaesthetized patients.<br />

While it is unlikely that a patient will receive acupressure<br />

or acupuncture during surgery, the question<br />

as to what causes BIS readings below 50 in awake<br />

subjects remains. It is unlikely to be a placebo effect<br />

as we have shown in several test measurements usin~<br />

placebo points that BIS is not affected by <strong>Laser</strong>needle<br />

stimulation per se. In the present study there were<br />

small statistically significant but not clinically important<br />

changes with needle acupuncture, <strong>Laser</strong>needle@<br />

acupuncture and acupressure at control point. These<br />

findings also help confirm that the BIS and SEF<br />

reductions induced by acupressure at Yintang are<br />

not a placebo effect. Reduced electromyographic<br />

levels could be partially responsible [21]. At the<br />

moment it is unclear to what degree system algorithms<br />

contribute to such findings. BIS is certainly<br />

affected by electrical activity nearby, especially<br />

diathermy. Therefore, there could also be a possibility<br />

that local movement in the region of the recording<br />

electrode might be responsible for the EEG effects<br />

observed. These are apparently less during control<br />

point acupuncture than during Yintang acupressure,<br />

where pressure is applied to a point immediately<br />

adjacent to the Zipprep@ electrode. Further investigations<br />

are necessary to clarify these questions.<br />

In conclusion, we found in healthy awake volunteers<br />

that acupressure at Yintang results in statistically<br />

significant and clinically relevant reductions in<br />

BIS and SEF while needle acupuncture, <strong>Laser</strong>needle@<br />

acupuncture and acupressure at a control point result<br />

in statistically significant but clinically unimportant<br />

reductions. Although the validity of BIS in anaesthesia<br />

is higher than that of SEF, BIS too has to be<br />

interpreted very carefully as our results show. Our<br />

results also highlight the EEG similarities of acupressure<br />

induced sedation and anaesthesia.<br />

Acknowledgements<br />

The author would like to express his thanks to Dr Lu<br />

Wang, Mag. Petra Petz and Evamaria Huber (Department<br />

of Biomedical Engineering and Research in<br />

Anesthesia and Intensive Care, University of Graz)<br />

for their valuable help.<br />

References<br />

Litscher G, Schwarz G. Noninvasive bioelectrical neuromonitoring<br />

in anaesthesia and critical care. Bur J Anaesthesiol<br />

2001; 18: 785-788.<br />

2. Litschet G. Editotial. The future of neuromonitoring.<br />

Internet J Neuromonitoring 2000; 1(1): http:/ /www.ispub.com/<br />

ostia/ index. php ?xmlF ilePath = journals/ i j nm/voll n 1/<br />

editorial2.xml<br />

3. Rampil IJ. A primer for EEG signal processing in anesthesia.<br />

Anesthesiology 1998; 89: 980-1002.<br />

4. Fassoulaki A, Paraskeva A, Patris K, Pourgiezi T,<br />

Kostopanagiotou G. Pressure applied on the extra 1<br />

acupuncture point reduces bispectral index values and<br />

stress in volunteers. Anesth Analg 2003; 96: 885-889.<br />

5. Stux G, Pomeranz B. Basics of Acupuncture. Berlin, Germany:<br />

Springer, 1998.<br />

6. Litscher G, Schikora D. Cerebral vascular effects of noninvasive<br />

laserneedles measured by transorbital and transtemporal<br />

Doppler sonography. <strong>Laser</strong> Med Sci 2002; 17:<br />

289-295.<br />

7. Litscher G, Schikora D. Near-infrared spectroscopy for<br />

objectifying cerebral effects of needle and laserneedle<br />

acupuncture. Spectroscopy 2002; 16: 335-342.<br />

8. Sebel PS, Lang E, Rampil IJ, et al. A multicenter study of<br />

bispectral electroencephalogram analysis for monitoring<br />

anesthetic effect. Anesth Analg 1997; 84: 891-899.<br />

9. LiuJ, Singh H, White PF. Electroencephalographic bispectral<br />

index correlates with intraoperative recall and depth of<br />

propofol-induced sedation. Anesth Analg 1997; 84: 185-189.<br />

10. HeckM, Kurnie B, BoldtJ, LangJ, Lehmann A, Saggau W.<br />

Electroencephalogram bispectral index predicts hemodynamic<br />

and arousal reactions during induction of anesthesia<br />

in patients undergoing cardiac surgery.J Cardiothorac Vasc<br />

Anesth 2000; 14: 693-697.<br />

11. Chan MTV, Gin T. What does the bispectral EEG index<br />

monitor? Eur J Anaesthesiol2000; 17: 146-148.<br />

12. Greif R, Laciny S, Mokhtarani M, et al. Transcutaneous<br />

electrical stimulation of an auricular acupuncture point<br />

decreases anesthetic requirement. Anesthesiology 2002; 96:<br />

306-312.<br />

13. Tsay SL, Chen ML. Acupressure and quality of sleep in<br />

patients with end-stage renal disease -a randomized control<br />

trial. Int J Nurs Stud 2003; 40: 1-7.<br />

14. Felhendler D, Lisander B. Pressure on acupoints decreases<br />

postoperative pain. ClinJ Pain 1996; 12: 326-329.<br />

15. Boehler M, Mitterschiffthaler G, Schlager A. Korean hand<br />

acupressure reduces postoperative nausea and vomiting after<br />

gynecologicallaparoscopic surgery. Anesth Analg 2002; 94:<br />

872-875.<br />

16. Eizember FL, Tomaszewski CA, Kerns WP. Acupressure<br />

for prevention of emesis in patients receiving activated<br />

charcoal.J Toxicol-Clin Toxicol2002; 40: 775-780.<br />

17. Cho ZH, Wong EK, Fallon JH. Neuro-Acupuncture. Los<br />

Angeles, USA: Q-Puncture, 2001.<br />

18. Litscher G, Cho ZH, eds. Computer Controlled Acupuncture@.<br />

Berlin, Germany: Pabst Science Publishers, 2000.<br />

19. Litscher G. High-Tech Akupunktur@. Berlin, Germany: Pabst<br />

Science Publishers, 2001.<br />

20. Hui KKS, Liu J, Makris N, et al. Acupuncture modulates<br />

the limbic system and subcortical gray structures of the<br />

human brain: evidence from fMRI studies in normal subjects.<br />

Hum Brain Mapp 2000; 9: 13-25.<br />

21. Bruhn J, Bouillon TW, Shafer SL. Electromyographic<br />

activiry falsely elevates the bispectral index. Anesthesiology<br />

2000; 92: 1485-1487.

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