Diagnostic Ultrasound - Abdomen and Pelvis
Gartner Duct Cyst TERMINOLOGY Abbreviations • Gartner duct cyst (GDC) • Gartner duct (GD) Definitions • Secretory retention cysts ○ Remnant of embryonic mesonephric (wolffian) ducts ○ Can occur anywhere along course of duct, most commonly anterolateral part of proximal 1/3 of vaginal wall IMAGING General Features • Best diagnostic clue ○ Solitary fluid-filled structure in anterolateral vaginal wall ○ Does not communicate with urethra • Size ○ Generally < 2 cm diameter • Same appearance as müllerian cysts: Remnants of paramesonephric duct, cannot be distinguished from each other Ultrasonographic Findings • Grayscale ultrasound ○ Cyst characteristics – Anechoic to hypoechoic – Increased through transmission – Well-defined wall separate from cervix ○ Infection or hemorrhage → increased echogenicity of fluid component ○ May contain septa ○ In rare cases, can become quite large and can cause urethral obstruction • Color/power Doppler ○ No internal flow on Doppler ○ Helps to confirm cystic nature rather than solid mass, such as vaginal tumor Radiographic Findings • GD may opacify on hysterosalpingography (HSG) if associated with fistula to vagina ○ Will opacify as focal dilated duct • GD runs parallel to cervical canal MR Findings • T1WI ○ Low signal intensity if simple fluid content ○ Intermediate to high signal intensity if content is hemorrhagic or proteinaceous in nature • T2WI ○ High signal fluid content • In anterolateral vaginal wall • When large or recurrent, may be multiloculated Imaging Recommendations • Best imaging tool ○ Transvaginal sonography is 1st modality of choice – Ultrasound may fail to differentiate GDC from urethral diverticulum if connection between diverticulum and urethra is not well seen – Light pressure with transducer will minimize compression of cyst – Partial withdrawal of transvaginal probe is helpful – Transperineal sonography is alternative • Protocol advice ○ Pelvic MR helpful to show location within vaginal wall/relationship to surrounding tissues – Always include kidneys on coronal scout images – Introduction of water-soluble gel into vagina immediately prior to study improves delineation of vaginal fornices ○ Improved imaging with endoluminal coil is reported in literature DIFFERENTIAL DIAGNOSIS Cystic Appearance • Nabothian cysts ○ Within cervix ○ Eccentric to cervical canal ○ GDC is adjacent to but separate from cervix • Vaginal inclusion cysts ○ Occur as result of obstetric or gynecologic trauma ○ Usually posterior wall – GDC are anterolateral in location ○ Ask patient about prior deliveries/surgeries • Endometriosis implant ○ More complex architecture ○ Thick wall, low-level internal echoes ○ Likely to have other manifestations of endometriosis ○ MR likely to show evidence of blood products • Urethral diverticulum ○ In midurethra, arising in posterolateral wall facing vagina – Communicates with urethra – Associated with frequency, urgency, postvoid dribbling – When large enough, wraps around urethra in horseshoe configuration • Ectopic ureterocele ○ Can occur any where between bladder neck and external urethral orifice ○ Associated with incontinence and urinary tract infection ○ Can present as cystic vaginal mass, ○ May produce filling defect on voiding cystourethrography (VCUG) Solid Appearance • Vaginal tumor ○ Extremely rare ○ Usually symptomatic ○ Solid mass; palpable, visible on speculum exam – Squamous cell carcinoma may undergo cystic degeneration – Vaginal sarcoma • Uterine/cervical fibroid ○ Prolapsed submucosal fibroid – Solid, protrudes though cervix – Visible on speculum exam Diagnoses: Female Pelvis 847
Gartner Duct Cyst Diagnoses: Female Pelvis ○ Cervical fibroid – Solid, arises from cervical stroma PATHOLOGY General Features • Associated abnormalities ○ Müllerian duct anomalies – Unicornuate, bicornuate, didelphys, or septate uterus – Carry ↑ risk for infertility, spontaneous abortion – May present with hematocolpos/primary amenorrhea in setting of müllerian anomalies ○ Renal anomalies – Ipsilateral renal dysgenesis/agenesis – Cross-fused ectopia/ectopic ureter ○ Diverticulosis of fallopian tubes (salpingitis isthmica nodosa) – Associated with increased incidence of infertility/increased risk for ectopic • Embryology ○ Mesonephric ducts normally resorb in females ○ Remnants form interrupted channel along genital tract → GD ○ Dilatation of lower portion of mesonephric duct remnants → GDC – Commonest in vaginal wall ○ Ureteral bud also develops from mesonephric duct – Associated renal/ureteric anomalies are common CLINICAL ISSUES Presentation • Most common signs/symptoms ○ Usually asymptomatic ○ Incidental finding on transvaginal ultrasound ○ Incidental finding on pelvic examination – Usually soft to palpation • Other signs/symptoms ○ May be symptomatic if large – Pelvic pressure symptoms – Dyspareunia – Obstructed labor – Mass at introitus described in neonate ○ May present with urologic symptoms – Cyst may be seen posterior to bladder or protrude into bladder, mimicking ureterocele – May cause ureteric or urethral obstruction – Reported cases of recurrent urinary retention in children requiring surgical resection of GDC – Urinary incontinence – Large GDC may mimic cystocele or urethral diverticulum Demographics • Epidemiology ○ Remnants of GD can be detected in 25% of adult women ○ GDC reported to occur in 1-2% of women Natural History & Prognosis • No specific treatment required if asymptomatic • Infection/hemorrhage may cause acute pain • Large cysts tend to be symptomatic • GDC may recur postoperatively ○ Recurrences tend to be multilocular – May be mistaken for ovarian carcinoma, lymphocele, abscess ○ Pelvic MR will show location inferior to levator plate • Clear cell adenocarcinoma or malignant female adnexal tumor of wolffian origin (FATWO) from GDC are very rare; can present with vaginal bleeding and irritation Treatment • If symptomatic ○ Aspiration ○ Sclerotherapy – Aspirate fluid – Inject with 5% tetracycline solution in volume equal to aspirate – Tetracycline solution reaspirated after 24 hours ○ Marsupialization ○ Surgical excision • Check uterine/renal anatomy for possible associated malformations DIAGNOSTIC CHECKLIST Consider • In young females with ipsilateral renal dysgenesis, a ureterocele-like "cyst" without associated ureteric dilatation is highly suspicious for GDC ○ Strong association with other wolffian duct as well as müllerian duct anomalies ○ Reported obstructing vaginal septum Image Interpretation Pearls • In infant with pelvic cyst, distension of vagina with saline allows confirmation that cyst arises in vaginal wall • Associated with müllerian duct/renal/ureteral anomalies ○ If cyst seen on pelvic imaging, check kidneys SELECTED REFERENCES 1. Shobeiri SA et al: Evaluation of vaginal cysts and masses by 3-dimensional endovaginal and endoanal sonography. J Ultrasound Med. 32(8):1499-507, 2013 2. Surabhi VR et al: Magnetic resonance imaging of female urethral and periurethral disorders. Radiol Clin North Am. 51(6):941-53, 2013 3. Dwarkasing RS et al: MRI evaluation of urethral diverticula and differential diagnosis in symptomatic women. AJR Am J Roentgenol. 197(3):676-82, 2011 4. Chaudhari VV et al: MR imaging and US of female urethral and periurethral disease. Radiographics. 30(7):1857-74, 2010 5. Bats AS et al: Malignant transformation of Gartner cyst. Int J Gynecol Cancer. 19(9):1655-7, 2009 6. Dwyer PL et al: Congenital urogenital anomalies that are associated with the persistence of Gartner's duct: a review. Am J Obstet Gynecol. 195(2):354-9, 2006 7. Macura KJ et al: MR imaging of the female urethra and supporting ligaments in assessment of urinary incontinence: spectrum of abnormalities. Radiographics. 26(4):1135-49, 2006 8. Prasad SR et al: Cross-sectional imaging of the female urethra: technique and results. Radiographics. 25(3):749-61, 2005 9. Hahn WY et al: MRI of female urethral and periurethral disorders. AJR 182:677-82, 2004 10. Eilber KS et al: Benign cystic lesions of the vagina: a literature review. J Urol. 170(3):717-22, 2003 11. Sherer DM et al: Transvaginal ultrasonographic depiction of a Gartner duct cyst. J Ultrasound Med. 20(11):1253-5, 2001 848
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Gartner Duct Cyst<br />
Diagnoses: Female <strong>Pelvis</strong><br />
○ Cervical fibroid<br />
– Solid, arises from cervical stroma<br />
PATHOLOGY<br />
General Features<br />
• Associated abnormalities<br />
○ Müllerian duct anomalies<br />
– Unicornuate, bicornuate, didelphys, or septate uterus<br />
– Carry ↑ risk for infertility, spontaneous abortion<br />
– May present with hematocolpos/primary amenorrhea<br />
in setting of müllerian anomalies<br />
○ Renal anomalies<br />
– Ipsilateral renal dysgenesis/agenesis<br />
– Cross-fused ectopia/ectopic ureter<br />
○ Diverticulosis of fallopian tubes (salpingitis isthmica<br />
nodosa)<br />
– Associated with increased incidence of<br />
infertility/increased risk for ectopic<br />
• Embryology<br />
○ Mesonephric ducts normally resorb in females<br />
○ Remnants form interrupted channel along genital tract<br />
→ GD<br />
○ Dilatation of lower portion of mesonephric duct<br />
remnants → GDC<br />
– Commonest in vaginal wall<br />
○ Ureteral bud also develops from mesonephric duct<br />
– Associated renal/ureteric anomalies are common<br />
CLINICAL ISSUES<br />
Presentation<br />
• Most common signs/symptoms<br />
○ Usually asymptomatic<br />
○ Incidental finding on transvaginal ultrasound<br />
○ Incidental finding on pelvic examination<br />
– Usually soft to palpation<br />
• Other signs/symptoms<br />
○ May be symptomatic if large<br />
– Pelvic pressure symptoms<br />
– Dyspareunia<br />
– Obstructed labor<br />
– Mass at introitus described in neonate<br />
○ May present with urologic symptoms<br />
– Cyst may be seen posterior to bladder or protrude<br />
into bladder, mimicking ureterocele<br />
– May cause ureteric or urethral obstruction<br />
– Reported cases of recurrent urinary retention in<br />
children requiring surgical resection of GDC<br />
– Urinary incontinence<br />
– Large GDC may mimic cystocele or urethral<br />
diverticulum<br />
Demographics<br />
• Epidemiology<br />
○ Remnants of GD can be detected in 25% of adult women<br />
○ GDC reported to occur in 1-2% of women<br />
Natural History & Prognosis<br />
• No specific treatment required if asymptomatic<br />
• Infection/hemorrhage may cause acute pain<br />
• Large cysts tend to be symptomatic<br />
• GDC may recur postoperatively<br />
○ Recurrences tend to be multilocular<br />
– May be mistaken for ovarian carcinoma, lymphocele,<br />
abscess<br />
○ Pelvic MR will show location inferior to levator plate<br />
• Clear cell adenocarcinoma or malignant female adnexal<br />
tumor of wolffian origin (FATWO) from GDC are very rare;<br />
can present with vaginal bleeding <strong>and</strong> irritation<br />
Treatment<br />
• If symptomatic<br />
○ Aspiration<br />
○ Sclerotherapy<br />
– Aspirate fluid<br />
– Inject with 5% tetracycline solution in volume equal to<br />
aspirate<br />
– Tetracycline solution reaspirated after 24 hours<br />
○ Marsupialization<br />
○ Surgical excision<br />
• Check uterine/renal anatomy for possible associated<br />
malformations<br />
DIAGNOSTIC CHECKLIST<br />
Consider<br />
• In young females with ipsilateral renal dysgenesis, a<br />
ureterocele-like "cyst" without associated ureteric<br />
dilatation is highly suspicious for GDC<br />
○ Strong association with other wolffian duct as well as<br />
müllerian duct anomalies<br />
○ Reported obstructing vaginal septum<br />
Image Interpretation Pearls<br />
• In infant with pelvic cyst, distension of vagina with saline<br />
allows confirmation that cyst arises in vaginal wall<br />
• Associated with müllerian duct/renal/ureteral anomalies<br />
○ If cyst seen on pelvic imaging, check kidneys<br />
SELECTED REFERENCES<br />
1. Shobeiri SA et al: Evaluation of vaginal cysts <strong>and</strong> masses by 3-dimensional<br />
endovaginal <strong>and</strong> endoanal sonography. J <strong>Ultrasound</strong> Med. 32(8):1499-507,<br />
2013<br />
2. Surabhi VR et al: Magnetic resonance imaging of female urethral <strong>and</strong><br />
periurethral disorders. Radiol Clin North Am. 51(6):941-53, 2013<br />
3. Dwarkasing RS et al: MRI evaluation of urethral diverticula <strong>and</strong> differential<br />
diagnosis in symptomatic women. AJR Am J Roentgenol. 197(3):676-82,<br />
2011<br />
4. Chaudhari VV et al: MR imaging <strong>and</strong> US of female urethral <strong>and</strong> periurethral<br />
disease. Radiographics. 30(7):1857-74, 2010<br />
5. Bats AS et al: Malignant transformation of Gartner cyst. Int J Gynecol Cancer.<br />
19(9):1655-7, 2009<br />
6. Dwyer PL et al: Congenital urogenital anomalies that are associated with the<br />
persistence of Gartner's duct: a review. Am J Obstet Gynecol. 195(2):354-9,<br />
2006<br />
7. Macura KJ et al: MR imaging of the female urethra <strong>and</strong> supporting ligaments<br />
in assessment of urinary incontinence: spectrum of abnormalities.<br />
Radiographics. 26(4):1135-49, 2006<br />
8. Prasad SR et al: Cross-sectional imaging of the female urethra: technique<br />
<strong>and</strong> results. Radiographics. 25(3):749-61, 2005<br />
9. Hahn WY et al: MRI of female urethral <strong>and</strong> periurethral disorders. AJR<br />
182:677-82, 2004<br />
10. Eilber KS et al: Benign cystic lesions of the vagina: a literature review. J Urol.<br />
170(3):717-22, 2003<br />
11. Sherer DM et al: Transvaginal ultrasonographic depiction of a Gartner duct<br />
cyst. J <strong>Ultrasound</strong> Med. 20(11):1253-5, 2001<br />
848