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Diagnostic Ultrasound - Abdomen and Pelvis

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Bladder Diverticulum<br />

Diagnoses: Urinary Tract<br />

– May occur anywhere<br />

□ Most common near ureteric orifices<br />

– Associated with syndromes<br />

□ Prune-belly syndrome<br />

□ Ehlers-Danlos<br />

□ Menkes kinky-hair syndrome<br />

□ Diamond-Blackfan syndrome<br />

○ Congenital: Hutch diverticulum (40%)<br />

– Weakness in detrusor muscle in paraureteral region<br />

– Associated ± vesicoureteric reflux<br />

• Associated abnormalities<br />

○ Vesicoureteral reflux (VUR)<br />

Gross Pathologic & Surgical Features<br />

• Bladder mucosa <strong>and</strong> submucosa herniates through weak<br />

areas in wall<br />

• Typically located at areas of congenital weakness of<br />

muscular wall at ureteral meatus or periureteral<br />

(posterolateral) bladder wall<br />

Microscopic Features<br />

• Uroepithelial lining<br />

Treatment<br />

• Options, risks, complications<br />

○ Complications<br />

– Carcinoma<br />

– Vesicoureteral reflux<br />

– Ureteral obstruction<br />

○ Indications for surgery <br />

– Persistent infection<br />

– Stone formation<br />

– Ureteral obstruction<br />

DIAGNOSTIC CHECKLIST<br />

Consider<br />

• Look for internal debris or filling defects, which may be<br />

calculi, hematoma, or tumor<br />

Image Interpretation Pearls<br />

• Differentiated from pelvic cysts by demonstration of<br />

diverticulum neck connecting to bladder in appropriate<br />

plane<br />

○ CTU or cystogram can help in differentiation<br />

CLINICAL ISSUES<br />

Presentation<br />

• Most common signs/symptoms<br />

○ Usually asymptomatic<br />

• Other signs/symptoms<br />

○ Hematuria due to complications<br />

– Calculi<br />

– Tumor due to chronic inflammation (in older patients)<br />

○ Large fluid-filled diverticulum may present with pelvic<br />

mass <strong>and</strong> may cause bladder outlet obstruction<br />

• Clinical profile<br />

○ Older male with benign prostatic hyperplasia (BPH)<br />

○ Spinal cord injury patient (neurogenic bladder)<br />

Demographics<br />

• Age<br />

○ 6th <strong>and</strong> 7th decade<br />

• Gender<br />

○ M:F = 9:1<br />

• Epidemiology<br />

○ Prevalence 1.7% in children<br />

○ Multiple diverticula in children<br />

– Neurogenic dysfunction<br />

– Posterior urethral valves<br />

– Prune belly syndrome<br />

Natural History & Prognosis<br />

• Wide neck diverticula<br />

○ Empty readily with bladder<br />

• Narrow neck diverticula<br />

○ Urinary stasis → complications such as infection, stone<br />

<strong>and</strong> ureteral obstruction<br />

• Secondary inflammation predisposes to development of<br />

carcinoma within diverticulum<br />

• Tumors in diverticula have worse prognosis<br />

○ Poorly formed wall <strong>and</strong> absence of muscle layer leads to<br />

more rapid local invasion into surrounding perivesical fat<br />

SELECTED REFERENCES<br />

1. Shebel HM et al: Cysts of the lower male genitourinary tract: embryologic<br />

<strong>and</strong> anatomic considerations <strong>and</strong> differential diagnosis. Radiographics.<br />

33(4):1125-43, 2013<br />

2. Alex<strong>and</strong>er RE et al: Bladder diverticulum: clinicopathologic spectrum in<br />

pediatric patients. Pediatr Dev Pathol. 15(4):281-5, 2012<br />

3. Debenedectis CM et al: Incidental genitourinary findings on<br />

obstetrics/gynecology ultrasound. <strong>Ultrasound</strong> Q. 28(4):293-8, 2012<br />

4. Aslam F et al: Acute urinary retention as a result of a bladder diverticulum.<br />

Int J Urol. 13(5):628-30, 2006<br />

5. Pace AM et al: Congenital vesical diverticulum in a 38-year-old female. Int<br />

Urol Nephrol. 37(3):473-5, 2005<br />

6. Yang JM et al: Transvaginal sonography in the diagnosis, management <strong>and</strong><br />

follow-up of complex paraurethral abnormalities. <strong>Ultrasound</strong> Obstet<br />

Gynecol. 25(3):302-6, 2005<br />

7. Shukla AR et al: Giant bladder diverticula causing bladder outlet obstruction<br />

in children. J Urol. 172(5 Pt 1):1977-9, 2004<br />

8. Wang CW et al: Pitfalls in the differential diagnosis of a pelvic cyst: lessons<br />

from a post-menopausal woman with bladder diverticulum. Int J Clin Pract.<br />

58(9):894-6, 2004<br />

9. Cappele O et al: A study of the anatomic features of the duct of the urachus.<br />

Surg Radiol Anat. 23(4):229-35, 2001<br />

10. Yu JS et al: Urachal remnant diseases: spectrum of CT <strong>and</strong> US findings.<br />

Radiographics. 21(2):451-61, 2001<br />

11. Maynor CH et al: Urinary bladder diverticula: sonographic diagnosis <strong>and</strong><br />

interpretive pitfalls. J <strong>Ultrasound</strong> Med. 15(3):189-94, 1996<br />

12. Bellah RD et al: Ureterocele eversion with vesicoureteral reflux in duplex<br />

kidneys: findings at voiding cystourethrography. AJR Am J Roentgenol.<br />

165(2):409-13, 1995<br />

13. Itoh N et al: Spontaneous rupture of a bladder diverticulum:<br />

ultrasonographic diagnosis. J Urol. 152(4):1206-7, 1994<br />

14. Levine D et al: Using color Doppler jets to differentiate a pelvic cyst from a<br />

bladder diverticulum. J <strong>Ultrasound</strong> Med. 13(7):575-7, 1994<br />

15. Dondalski M et al: Carcinoma arising in urinary bladder diverticula: imaging<br />

findings in six patients. AJR Am J Roentgenol. 161(4):817-20, 1993<br />

16. Farhi J et al: Giant diverticulum of the bladder simulating ovarian cyst. Int J<br />

Gynaecol Obstet. 36(1):55-7, 1991<br />

17. Dragsted J et al: Urothelial carcinoma in a bladder diverticulum evaluated by<br />

transurethral ultrasonography. Sc<strong>and</strong> J Urol Nephrol. 19(2):153-4, 1985<br />

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