BioMaxCoQ10 Professional detailer CoyneHealthcare1701026_DetailAid_Bio-Max-Web

Biomax
MicroActive ® CoQ10

Product Information For Biomax® Co-Enzyme Q10
Proprietary name
Product composition
Product specifications
Ingredient source
Pharmacological action
Indications
Contraindications
Medicinal interactions
Interactions with diseases or conditions
Pregnancy and breastfeeding
Warnings
Dosage and directions for use
Known symptoms of overdose and particulars of its treatment
Identification
Presentation
Storage conditions

What is Co-Enzyme Q10?
Co-Enzyme Q10 is a fat-soluble vitamin-like compound. It is also known as ubiquinone,
ubidecarenone, coenzyme Q and sometimes abbreviated to CoQ10, CoQ, Q10. It is found in almost
every eukaryotic cell of the body, primarily in the mithochondria. It is a component of the electron
transport chain and therefore participates in aerobic cellular respiration which is responsible for
generating energy in the form of adenosine triphosphate (ATP). More than 75 percent of the body’s
energy is produced this way.
The highest concentrations of Co-Enzyme Q10 are found in those organs with the highest energy
requirements, such as the heart, liver, kidneys and pancreas. CoQ10 is concentrated in these organs
because it is essential to the process of producing cellular energy from the food you eat.
The other functions of Co-Enzyme Q10 include activity as an antioxidant, a membrane stabilizer,
and as a cofactor in many metabolic pathways.
Distribution in the Body
CoQ10 is made naturally in the body, but deficiency may occur due to disease, low dietary intake,
The concentration of Coenzyme Q10 in the body decreases
year by year, indicating that it has a close relationship with aging.
the use of certain medications or high CoQ10 use by the body. The concentration of CoQ10 in the
body decreases year by year suggesting a relationship with aging and the related risk of deficiency.
100%
CoQ10
Levels 100% 95.3%
83%
Liver
72.6%
68.2%
Lungs
Kidneys
65.3%
51.7%
Heart
42.9%
20 Years 40 Years 60 Years 80 Years
Distribution in the body
The concentration of Coenzyme Q10 in the body decreases
year by year, indicating that it has a close relationship with aging

Symptoms of deficiency include
• Loss of muscle control
• Cardiomyopathy
• Muscle weakness
• Cerebellar atrophy
• Physical and mental fatigue
• Seizures
• Chronic pain / headaches
• Low mood
Patient’s at risk of CoQ10 deficiency
• Over the age of 30
• The use of certain chronic medications
• Neuromuscular disease
• Neurological disease
• Cardiovascular disease
• IBS, Crohn’s disease, celiac disease
• Chronic fatigue syndrome
• Fibromyalgia
• Overweight
Medications causing deficiency include
Anti-hypertensive
Medications
• Beta Blockers
• Thiazide
• Hydralazine
• Methyldopa
• Clonidine
Cholesterol Lowering
Medications
• Gemfibrozil
• Statin Drugs/HMG-CoA
Reductase inhibitors
Anti-Psychotic/Anti-
Depressant Medications
• Haloperidol
• Phenothiazines
• Tricyclic

The Problem With Traditional Co-Enzyme Q10
Supplementation
One of the major challenges for using oral CoQ10 therapeutically has been absorption. Standard
crystalline powders are absorbed at a rate of less than 1%.
Being a lipophilic compound, the efficiency of absorption is poor because of its:
• Insolubility in water
• Relatively large molecular weight
• Limited solubility in lipids
•
It has also been found that the higher the ingested dose, the lower the percentage of dose
absorbed. This then calls for smaller doses spread throughout the day.
There are a number of liposome, micelles and nanoparticulated CoQ10 supplements commercially
available said to overcome the challenge of poor CoQ10 absorption. Studies indicate that these
solubilized products may provide uptake benefits for some people but not others.
Some challenges faced with these products include:
• Cost
• Inclusion of undesirable synthetics which irritate gut
• Questionable universal absorption in all users
• Multiple daily dosing for efficacy
Ubiquinol vs Ubiquinone
CoQ10 exists either in its oxidized form, ubiquinone, or in its reduced form, ubiquinol.
Ubiquinone and ubiquinol are redox pairs in that one can be rapidly converted to the other
and vice versa in areas where their specific functions are required.
Ubiquinone is a cofactor in the inner membrane of the mitochondria for the synthesis of energy
(ATP). Ubiquinone, through its synthesis of energy, is involved in all body processes requiring
energy: energy synthesis, active transport, membrane and nucleotide stability, synthesis of
enzymes, coenzymes, hormones, neuro-transmitter synthesis and reuptake, ciliary activity in
the upper respiratory systems, all muscle contractile functions, sperm production and motility,
deactivation of muscle contraction, pumping action of sweat and other cutaneous glands.
Ubiquinol is an antioxidant throughout the body. This is especially true in the cell membranes and
those of the cell organelles. In these membranes CoQ10 may well be the primary lipophilic molecule
essential for the prevention of lipid peroxidation resulting in cell damage and eventually cell death.

Key Benefits Of Biomax® CoQ10
Biomax® CoQ10 uses revolutionary new MicroActive® CoQ10. The patented MicroActive® process
(U.S. 7,030,102) complexes each CoQ10 molecule with two ß-cyclodextrin molecules in a water
media. ß-cyclodextrin is used extensively in the food and pharmaceutical industries. It is a GRAS
compound formed through an enzymatic conversion of starch. One side of the molecule is fatsoluble
and holds the CoQ10, while the other side is water-soluble and makes for efficient transport
through the digestive system. When the micronized MicroActive® complex arrives at a cell, it comes
apart, depositing a single CoQ10 molecule for efficient absorption.
0.45
0.40
0.35
0.30
0.25
0.20
0.15
0.10
0.05
0
Biomax® CoQ10
• 370% better absorption than crystalline CoQ10
• 158% better absorption than solubilised CoQ10
• 24 hour time release
• Universally enhanced absorption in all users
• Double CoQ10 levels in 3 weeks MicroActive ® CoQ10
• Validated through human clinical studies
• No artificial additives Solubilized CoQ10
0
5
Biomax CoQ10 Promises “Assured Bioavailability”
Many advanced CoQ10 products claim to be “more bioavailable” by demonstrating improved
uptake for a group 0.7 of subjects. The problem is that within this group some subjects are naturally
“super” absorbers, while others still show poor uptake. In contrast, MicroActive® CoQ10
0.6
0.5
demonstrates superior absorption in all subjects, not just a few. This is why all subjects in the threeweek
study by Madhavi and Kagan (2010) doubled their CoQ10 levels, compared with the control
0.4
group in which only 44% of subjects doubled their CoQ10 MicroActive levels.
® CoQ10
Madhavi, D., Kagan, D. 0.3 A study on the bioavailability of a sustained-release coenzyme Q10-ß-Cyclodextrin complex.
Integrative Medicine, 9(1): 0.2 20-24.
0.1
10 15 20 25
HOURS
Crystalline CoQ10
Individual Subjects’ 0
CoQ10 Absorption After Single
0 5
10
15 20 25
Oral Dose
HOURS
25
20
15
10
universally
bioavailable
bioavailable,
not universal
5
marginally
bioavailable
0
MicroActive ®
Solubilized
Products
Crystalline

0.20
0.15
0.10
0.05
0
MicroActive ® CoQ10
Solubilized CoQ10
05
05
MicroActive® vs Crystalline CoQ10
10 15 20 25
HOURS
0.7
0.6
0.5
0.4
MicroActive ® CoQ10
0.3
0.2
0.1
0
Crystalline CoQ10
0 5
10
15 20 25
HOURS
MicroActive® vs Oil Solubilized CoQ10 Softgel
0.45
0.40
0.35
0.30
0.25
0.20
0.15
0.10
0.05
0
0
Muscle
Muscle COKM
MicroActive ® CoQ10
Solubilized CoQ10
5
10 15 20 25
HOURS
0.7
0.6
0.5
0.4
Indication 0.3
Daily Dose Biomax® CoQ10
0.2
0
CoQ10 RECOMMENDATIONS AND GUIDELINES
MicroActive ® CoQ10
Hypertension 0.1
200mg 1 Capsule
Crystalline CoQ10
Statin use 100mg 1 Capsule
0 5
10
15 20 25
Cardiomyopathy 400mg HOURS 1 -2 Capsules
25
20
15
10
Healthy patients over 40 100mg 1 Capsule
Statin-associated myopathy 200mg-600mg 1-2 Capsules
Angina pectoris 150mg 1 Capsule
Heart attack recovery 100mg-150mg 1 Capsule
Parkinson’s disease 1400mg 4 Capsules
Alzheimers’s disease 1200mg-1400mg 4 Capsules
Improved sperm function 200mg-300mg 1 Capsule
Endurance athletes 300mg 1 Capsule
universally
bioavailable
bioavailable,
not universal
5
marginally
bioavailable

Comparison with other Co-Enzyme Q10 supplements
1 Capsule
Biomax
CoQ10®
MicroActive ® CoQ10
= (3.5) x 50mg Solubilised CoQ10
= (6.5) x 50mg Crystalline CoQ10
= (2.5) x 30mg Nano-particulate CoQ10
(Polysorbate 80)
Biomax® CoQ10 Guarantees Universal Absorption In All Users
CoQ10 Recommendations And Guidelines
Product Information For Biomax® CoQ10
PROPRIETARY NAME (AND DOSAGE FORM):
Biomax® CoQ10 (capsules)
PRODUCT COMPOSITION:
Each capsule contains the following as active ingredient:
MicroActive® CoQ10 Complex
280 mg
Comprised of:
Co-enzyme Q10 26% [ubiquinone]
β-Cyclodextrin
72 mg
208 mg
PRODUCT SPECIFICATIONS
Crystal-free
CoQ10 complexed with cyclodextrin
Light yellow free-flowing 60 mesh powder
26% CoQ10 concentration
Stable at room temperature
Water-dispersible
INGREDIENT SOURCE
Ingredient
β-Cyclodextrin
Co-Enzyme Q10
Source
Plant
Micro-organism

PHARMACOLOGICAL ACTION:
Co-Enzyme Q10 is a fat-soluble vitamin-like compound that can found in almost every eukaryotic
cell of the body. It can be found in very high concentrations in the heart, pancreas, liver and kidneys.
Some of its functions seem to include activity as a cofactor in a number of metabolic pathways,
one in particular being the production of the energy rich molecule adenosine triphosphate (ATP) in
oxidative respiration. Other primary functions seem to include activity as a membrane stabilizer,
and as an antioxidant.
INDICATIONS:
For individuals using “statin” cholesterol medicines, Biomax CoQ10 is recommended as a highly
bioavailable compound to prevent Co-Enzyme Q10 deficiency. Co-Enzyme Q10 may help to
maintain and support cardiovascular health. Research has indicated that Co-Enzyme Q10 may
also help reduce the frequency of migraine headaches and the associated nausea when used
prophylactically. Co-Enzyme Q10 is a fat-soluble vitamin-like compound present in virtually all cells
and some of its primary functions seem to include activity as an antioxidant, a membrane stabilizer
and as a cofactor in many metabolic pathways, particularly in the production of ATP, important for
cellular energy production.
CONTRAINDICATIONS:
There are no known contraindications.
MEDICINAL INTERACTIONS:
Antihypertensive medication: Co-Enzyme Q10 can decrease blood pressure and might have
additive blood pressure lowering effects when used with antihypertensive medications, use with
caution.
Chemotherapy: Preliminary evidence suggests that inhibition of co-enzyme Q10 dependant
enzymes and decreased co-enzyme Q10 synthesis in the heart might contribute to the
cardiotoxicity caused by doxorubicin. Theoretically, taking co-enzyme Q10 supplements
might prevent this toxicity. There is, however, also a concern that co-enzyme Q10 might
lower effectiveness of doxorubicin. Co-Enzyme Q10 does not seem to significantly alter the
pharmacokinetics of doxorubicin.
Warfarin: Concomitant use might reduce the anticoagulation effects of warfarin. Co-Enzyme Q10
is chemically similar to menaquinone and might have vitamin K-like procoagulant effects. Closely
monitor individuals taking warfarin and co-enzyme Q10. Dose adjustment may be necessary.
INTERACTIONS WITH DISEASES OR CONDITIONS
Hypotension, hypertension: Co-Enzyme Q10 might lower blood pressure. It can have additive
effects with medications used for hypertension, use with caution.
Smoking: Cigarette smoking depletes body stores of co-enzyme Q10.
Surgery: Co-Enzyme Q10 might affect blood pressure. Theoretically, co-enzyme Q10 might interfere
with blood pressure control during and after surgical procedures. Individuals are advised to
discontinue co-enzyme Q10 at least 2-weeks before elective surgical procedures.

PREGNANCY AND BREASTFEEDING:
Safety in pregnancy and breastfeeding has not been established.
WARNINGS:
Do not exceed recommended dosages unless on the advice of a health care provider. Do not use
this product if you are allergic to any of the ingredients. If you are on any medication or suffering
from any medical condition, it is advisable to seek medical advice before starting any new medicine,
supplement or remedy.
POSSIBLE SIDE EFFECTS AND SPECIAL PRECAUTIONS
Common side effects may include upset stomach, diarrhoea, nausea vomiting and loss of appetite,
skin rashes and low blood pressure.
Not all side effects for Co-Enzyme Q10 may be reported.
Always consult your healthcare practitioner or pharmacist for medical advice.
DOSAGE AND DIRECTIONS FOR USE
Adults: Take 1 capsule daily after a meal.
KNOWN SYMPTOMS OF OVERDOSE AND PARTICULARS OF ITS TREATMENT
Treat should be symptomatic and supportive. In the case of accidental overdose of the product,
contact the nearest hospital or poison control centre.
IDENTIFICATION
Clear vegetarian capsule shell (0) containing light yellow free flowing powder.
PRESENTATION
White glass bottle with metal screw cap and seal for protection. Contains 30 powder filled capsules.
STORAGE INSTRUCTIONS
Store in a cool dry place below 25 degrees Celsius. Keep out of reach of children.
Notes

Biomax
MicroActive ® CoQ10

info@coynehealthcare.co.za
Phone: 021 421 9144
Moorings 1 Portswood Road
V&A Waterfront Cape Town