Dr.Inshad Ali Khan - Indian Institute of Integrative Medicine (IIIM)

CURRICULUM VITAE
Name INSHAD ALI KHAN
Date of Birth May 27, 1968
Citizenship Indian
Marital status Married
Present Address Clinical Microbiology Unit
Indian Institute of Integrative Medicine (CSIR),
Canal Road, Jammu Tawi 180001. (INDIA)
Phone: 0191-2572002, 2544382, 2578206
Email inshad@rediffmail.com, iakhan@iiim.res.in
Phone: 0191-2572002, 25
Permanent Address D-31, Lane No.1, Batla House,
Jamia Nagar, New Delhi-110025, (INDIA)
Phone No.+91- 11-26981978
Education:
Degree Year Division University/College Subjects
Ph.D 1996 Awarded Jamia Millia Islamia, "Molecular fingerprinting of
New Delhi
Salmonella typhi."
M.Sc Biological 1992 First Jamia Millia Islamia, Biochemistry, Microbiology,
Sciences
New Delhi
Immunology, Molecular
genetics, Biophysics, Protein
Chemistry, Plant physiology,
Animal physiology, Ecology
Positions held:
Post held Duration Place Job Responsibilities
Scientist „E1‟ Aug 2006 Biotechnology Division, Indian Research
till date Institute of Integrative Medicine
(CSIR), Jammu Tawi, India
Scientist „C‟ Nov 2003 Biotechnology Division, Indian Research
July 2006 Institute of Integrative Medicine
(CSIR), Jammu Tawi, India
Scientist May 2002- Biotechnology Division, Indian Research
Fellow Nov 2003 Institute of Integrative Medicine
(CSIR), Jammu Tawi, India
Research Nov 2000 – Department of Microbiology
Research & Development
Scientist May 2002 (New Chemical Entity Research), program on New Drug
Lupin Research Park, 46A/47A,
Pune 411042 Maharastra, INDIA
Discovery Research
Research Dec 1996 - Department of Microbiology
Research & Development
Scientist Nov 2000 (New Drug Discovery Research), program on New Drug
Ranbaxy Research Laboratories,
Gurgaon, Harayana, INDIA
Discovery Research

Present Status: Scientist „E1‟ and scientist in-charge of BSL-3 lab, Biotechnology Division,
Indian Institute of Integrative Medicine (CSIR), Jammu Tawi, India,
Details of Research experience (1992-till date):
The Ph.D work was carried out in the Department of Microbiology, AIIMS, under the
supervision of Dr. Ashok Rattan, Additional Professor. The work included the
characterization of bacterial strains of Salmonella typhi biochemically, serologically,
and by molecular typing methods such as Whole Cell Protein analysis (WCPA) by
SDS- PAGE. Finally all these methods were compared with 16S r RNA typing.
Worked as research scientist in Department of Microbiology, Ranbaxy Research Labs
(India's leading pharmaceutical industry). Actively involved in screening of new
chemical entity (NCEs) for its antibacterial, antifungal and anti-mycobacterial activity
based on NCCLS guidelines, screening the new molecules for there in vivo activities
in mice, guinea pig and rat models for IND directed studies.
Worked as research scientist with Lupin Laboratories Ltd, Pune, Maharastra. The
research area was NCEs research on anti-infectives with focus on antimycobacterial
compounds. Established in-vivo models of M. tuberculosis in mice and guinea pig.
Achieved expertise in intranasal mice model of M. tuberculosis, intranasal and
intracranial mice models of C. neoformans.
Working as Scientist E1 and scientist in-charge of BSL-3 lab in Biotechnology
Division of Indian Institute of Integrative Medicine, Jammu. Established the antiinfective
screening facility and initiated the anti-infective screening. Principal
Investigator and active member in laboratory's various research programs, presently
heading the anti infective group. My group is extensively screening the plant extracts,
essential oils and phytomolecules for therapeutic and non-therapeutic uses. One of the
main objectives of our research is to look for more efficacious combination of
phytomolecules with anti-infective agents. Such combinations can reduce the
emergence of resistance in microorganisms. One such topical combination from our
group is already in the clinical trials. The group also actively working on the
combination therapy of antiTB drugs with plant based Immunomodulators. Such
combinations are aimed at shortening the treatment regimen of TB and prevention of
relapse of TB due latency.
Drug efflux is one of the major cause resistances in microorganisms. The group is
also working bacterial efflux pumps by cloning and expressing them in E coli host.
At the same time we are also designing the synthetic molecules as inhibitors of these
efflux pumps.
We are also exploring the new therapeutic targets in M tuberculosis by using In vivo
Induced Antigen Technology (IVIAT). This technology utilizes the pooled sera from
TB patents to detect the antigens expressed under diseased condition.

Major research areas:
Anti-infective research with reference to identification of plant derived pharmacophores.
Antimicrobial resistance and microbial efflux pumps.
New drug targets and immunotherapeutics for M.tuberculosis.
Regulation of M. tuberculosis gene expression.
Oral microbiology
Achievements
Identification of piperine as bacterial efflux pump inhibitor.
Development of topical antibacterial formulation consisting of a combination of
known antibacterial agent and bacterial efflux pump inhibitor. This formulation has
shown better efficacy than the original formulation in mice model of skin infection.
Development of two natural based oral care rinse formulations for Procter & Gamble,
USA. These formulations are advanced stages of development.
Major national and international funded projects:
Identification of bioenhancers/ test actives for oral care application- Colgate-
Palmolive, USA. (Completed)
Herbal health care compositions having anti-microbial, anti-oxidant and anti-
inflammatory properties- Procter & Gamble, USA. (Completed)
Natural additives for baby care wipes formulations- Procter & Gamble, USA.
(Completed)
Characterization, fractionation and molecular identification of SK-II Pitera
bioactivity- Procter & Gamble, USA. (Completed)
Exploitation of India‟s rich microbial biodiversity- Network project under 11 th FYP,
CSIR. (Ongoing)
Synthesis and antitubercular activity of Benzothiadiazine, Coumarin and Diarylprrole
congeners- DST funded. (Ongoing)

Identification of Mycobacterium tuberculosis genes differentially expressed in TB
patients- DST funded. (Ongoing)
Identification, Design and Validation of novel inhibitors of putative multidrug
resistant efflux pump Rv1258c of Mycobacterium tuberculosis OSDD, CSIR funded.
(Ongoing)
Whole cell screening of library of drug like compounds from Chembridge database-
OSDD, CSIR funded. (Ongoing)
Fellowships, memberships and honors:
Qualified the Graduate Aptitude Test in Engineering (GATE) 1993 with a percentile
score of 84.62 to avail UGC fellowship.
Life member of Indian Association of Medical Microbiologists (IAMM) since1994.
Best paper award, Year 2005-06 for the research paper “ Piperine, a phytochemical
potentiator of ciprofloxacin against Staphylococcus aureus” by Regional Research
Laboratory (CSIR), Canal road, Jammu. (Senior author)
2 nd Best paper award, Year 2007-08 for the research paper “Novel structural
analogues of piperine as inhibitors of the NorA efflux pump of Staphylococcus
aureus” by Indian Institute of Integrative Medicine (CSIR), Canal road, Jammu.
(Senior author)
2 nd Best paper award, Year 2008-09 for the research paper “Evaluation of the
antimicrobial, antioxidant and anti-inflammatory activities of hydroxychavicol for its
potential use as oral care agent” by Indian Institute of Integrative Medicine (CSIR),
Canal road, Jammu. (Senior author)
Professional trainings and visits abroad
Visited Germany in connection with collaborative project with Proctor & Gamble,
Germany (Jan 2007)
Visited USA in connection with collaborative project with Proctor & Gamble and
Colgate-Palmolive (Jan 2007)
Visited Bangkok to participate in Biosafety and Biosecurity workshop, Bangkok,
Thailand, (April 2007)
Visited USA to attend a training program on biosafety and biosecurity, Albuquerque,
NM (24 th April-3 rd May 2009)

Research Training/ Workshop/ Conferences attended:
June 1994. Participated in NAMS/ICMR/ AIIMS workshop on quality-controlled
determination of antibiotic susceptibility held at AIIMS, New Delhi.
Attended the International Symposium On AIDS And Hepatitis. Organized by
Department of Gastroenterology and Human Nutrition, AIIMS, New Delhi, January
9th to 12th 1997.
Attended the IUBMB Symposium on DNA Enzymes: Structure & Mechanisms
organized by Departments of Biochemistry and Microbiology and Cell Biology,
Indian Institute of Sciences, Bangalore, India, Dec 1st to 3rd 2000.
Attended the WHO sponsored workshop on Non-clinical safety testing organized by
CDRI, at New Delhi from 24 th to 26 th Oct 2005.
Attended a training programme on “Laboratory Quality System, Management and
Internal Quality Audit” organized by NABL, at NITS, BIS, Noida from 6 th to 9 th June
2005.
BSL lab training:
BSL3 onsite biosafety training program conducted by Emory University, NSITE,
USA at NIV Pune from 9 th Feb to 13 th Feb 2009.
Controlling Laboratory Biorisks Training Course conducted by International
Biological Threat Reduction, Sandia National Laboratories at Albuquerque, USA
from 27 th April to 2 May 2009.
Recognized guide for Ph.D. degree in Microbiology and Molecular Biology at:
Guru Nanak Dev University, Amritsar
Bharti Vidyapeeth University, Pune
Shri Mata Vaishno Devi University, Katra, Jammu
Supervision of research:
Thesis awarded: 05
1. Manoj Kumar- “Identification of in-vivo expressed antigens of Mycobacterium
tuberculosis in HIV positive TB patients using IVIAT.” – 2009
2. Ashwani Kumar- “ Piperine, a phytochemical potentiator of ciprofloxacin against
Staphylococcus aureus.”- 2010
3. Zahid Mehmood Mirza- “Synergistic interaction of piperine with mupirocin
against Staphylococcus aureus infection.”-2011
4. Intzr Ali- “ Plant derived molecules as potential antifungal agents.”-2011

Patents:
5. Sandeep Sharma- “ Piperine as bioefficacy enhancer of rifampicin against
Mycobacterium tuberculosis infection.”-2011
Thesis ongoing: 03
1. Furqan Ali- “Evaluation of plant derived molecules as oral care agents and
elucidation of their mechanism of action.”
2. Anshu Beulah Ram- “ Expression studies of putative efflux proteins of
Mycobacterium tuberculosis.”
3. Nitin Pal Kalia- “Evaluation of Capsaicin and its structural analogs as multidrug
efflux pump inhibitors of Staphylococcus aureus”
1. Surrinder Koul, Venkat M Reddy, Pyare Lal Sangwan, Budh Singh, Ch Parveen
Kumar, Inshad Ali Khan, Nitin Pal Kalia, Ram Vishwakarma. Novel diaamides as
potentiators of bioefficacy of drugs. (US patent applied NF0042/2011)
2. Ammed Kamal, Arutla Viswanath, Jayanti Naga Srirama Chandra Murthy, Farheen
Sultana, Gadupudi Ramakrishna; Inshad Ali Khan, Nitin Pal Kalia. Phenyl
nitrofurfuryl linked piperidino-oxadiazolone conjugates as anti-tubercular agents and process
for the preparation thereof. (US patent applied 2011)
3. Ahmed Kamal, Shaik Azeeza, Shaik Ahmed Ali, Malik, M Shaheer, Inshad Ali
Khan, Sheikh Tasduq Abdullah, Sandeep Sharma and Anshu Beulah Ram. A process
for the synthesis of new quinolylpiperazino substituted congeners of thiolactomycin
as anti-tubercular antibiotics. (US patent applied 0073NF2010/IN)
4. Ahmed Kamal, Rajesh VCRNC Shetti, P. Swapna, Shaik Azeeza, A. Malla Reddy,
Inshad Ali Khan, Sheikh Tasduq Abdullah, Sandeep Sharma, and Anshu Beulah
Ram. Synthesis of benzothiazole derivatives as potential anti-tubercular agents. (US
patent applied)
5. Subramanyam R., Du Thumm L., Qazi, G.N., Khan I.A., Suri, K.A., Satti, N.K., Ali,
F., Kalia, N.P. Chalcones as Enhancer of Antimicrobial Agents. (2011, WO
2011/2011/075136 A1)
6. Jorge C.S, Mathias H, Qazi G.N, Khan I.A, Suri K.A, Satti N.K. Substrate
impregnated with a composition comprising hydroxychavicol. (2009,US patent
applied)
7. Koul S., Reddy M. V., Thota N., Koul J. L., Sangwan P. L., Taneja S. C., Khan, I.
A., Kumar, A., Kalia, N. P., Abdullah T. S., Johri R. K., Pagoch S. S., Tikoo A. K.,
Tikoo M. K., Saxena A. K., Agrawal S. K., Mondhe D. M., Purnima B., Sharma
S., Singh S., Singh G. D., Bhusari S., Qazi G. N. Novel aromatic amides as
potentiators of bioefficacy of drugs. (Del-2496/2010)

8. Koul, S.; Niranjan, T.; Reddy, M.V.; Sangwan, P.L.; Taneja, S.C.; Khan, I.A.;
Kumar, A.; Raja, A.F.; Saxena, A.K.; Agrawal, S.K.; Johri, R.K.; Abdullah, T.S.;
Singh, G.; Rao, B.L.N.; Dhar, A.K.; Purnima, B.; and Qazi, G.N. Preparation of novel
efflux pump inhibitors. (Patent granted: WO/2009/110002)
9. Kaul, A.; Bani, S.; Suri, K.A.; Satti, N.; Kapahi, B. K.; Gupta, V. K.; Khan, I.A.;
Khan, B.; Dutt, P.; Ali, I.; Sehar I.; and Qazi, G. N. Plumieride: an
immunostimulating agent from Plumeria rubra leaves. (0107NF 2007, dated 10-07-
2007).
10. Koul, S.; Koul, J. L.; Taneja, S. C.; Gupta, P.; Khan, I. A.; Mirza, Z. M.; Kumar, A.;
Johri, R. K.; Pandita, M.; Khosa, A.; Tikko, A. K.; Sharma, S. C.; Verma, V.; and
Qazi, G. N. 2006. Aromatic amides as potentiators of bioefficacy of anti-infective
drugs (0472NF2004,US. Pre-grant Pub. No. 20070004645, WO 2006/103527A1).
11. Qazi, G.N.; Singh, J.; Malik, F.; Saxena, A.K.; Suri, K.A.; Satti, N.K.; Kumar, A.;
Kumar, A.; Bhushan, S.; Khan, I.A.; Mondhe, D.M.; Muthiah, S.; Chandra, H.;
Gupta, A.; Kumar, M.; Sharma, S.; and Singh, S. “A synergistic formulation from
Withania Somnifera useful for anti-cancer and TH1 dominant immune up-regulating
activities”. (0202NF2006 dated 06-09-2006)
12. Qazi, G.N.; Suri, O.P.; Bedi, K.L.; Khan, I.A.; Verma, V.; Johri, R.K.; Suri, K.A.;
Gupta, B.D.; Satti, N.K.; Tikoo, M.K.; Sharma, S.C.; and Tikoo, A.K. Use of herbal
agents as potentiators of anti infectives (Patent granted: US patent no. 7119075)
Papers Presented In Conferences/ Symposium:
(1) Presented a paper on " Molecular fingerprinting of Salmonella typhi" at XIX National
Congress of Indian Association of Medical Microbiologists, Pondicherry, 1995.
(2) Presented a paper on " Ribotyping of Salmonella typhi in New Delhi INDIA" at XX
National Congress of Indian Association of Medical Microbiologists, Agra, 1996.
(3) I.A. Khan*, S. Koul, S.C. Taneja, A. Kumar, I. Ali, V. Verma and G.N. Qazi. SK-20-
Potentiator of mupirocin‟s activity. Poster presented at 46 th annual conference of
association of microbiologists of India, Hyderabad, 8-10 December 2005.
(4) M. Kumar, I.A.Khan*, S. Sharma, V. Verma and G.N. Qazi. Application of nitrate
reductase assay in microtitre formate for rapid MIC determination of Mycobacterium
tuberculosis. Poster presented at XXIX- National congress of Indian Association of
Medical Microbiologists, Chennai, 21-23 October 2005.

(5) I.A.Khan*, Z.M. Mirza, I. Ali, V. Verma and G.N. Qazi. Piperine, a phytochemical
potentiator of ciprofloxacin aganisnt staphylococcus aureus. Poster presented at
XXIX- National congress of Indian Association of Medical Microbiologists, Chennai,
21-23 October 2005
(6) I.A. Khan*, F.G. Khan, M. Kumar, S. Sharma, L.R. Manhas, S. Bani, A. Koul and
G.N. Qazi. Plants based immunomodulator as adjunct to anti TB drugs. Poster
presented at International Symposium on new frontiers in tuberculosis research,
ICGEB, New Delhi on December 4-6, 2006.
(7) Kumar, M., I. A. Khan*, F. G. Khan, S. Sharma, A. B. Ram, and G. N. Qazi. An
efficient and rapid mycobacterial DNA extraction method from clinical samples for
early diagnosis of tuberculosis using polymerase chain reaction. Poster presented at.
International Conference on New Horizons in Biotechnology (NHBT-2007),
Trivandrum, 26-29 November 2007.
(8) A. Kumar, I.A. Khan*, P.R. Sharma, I. Ali, A.F. Raja and G.N. Qazi. Nitrate
reductase assay for antibiotic susceptibility determination of biofilm formed by
Staphylococcus aureus. Poster presented at International Conference on New
Horizons in Biotechnology (NHBT-2007), Trivandrum, 26-29 November 2007.
(9) A.F. Raja, I.A. Khan*, I. Ali, F. Ali, M. Kumar, A.R. Ram, B.A. Shah, S.C Taneja
and G.N. Qazi. Antimicrobial activities of boswellic acids from Boswellia serrata.
Poster presented at 48 th annual conference of association of microbiologists of India,
Chennai, 18-21 December 2007.
(10) M. Kumar, I.A.Khan*, F.G.Khan, S. Sharma and G.N. Qazi. Identification of
Mycobacterium tuberculosis genes uniquely expressed in tuberculosis patients. Poster
presented at International symposium on emerging trends in tuberculosis research:
biomarkers, drugs and vaccines, ICGEB, New Delhi on December 1-3, 2008.
(11) S. Sharma, I.A.Khan*, M. Kumar and A.B. Ram. Piperine as bioefficacy enhancer of
Rifampicin against Mycobacterium tuberculosis infection. Poster presented at
International symposium on emerging trends in tuberculosis research: biomarkers,
drugs and vaccines, ICGEB, New Delhi on December 1-3, 2008.
(12) F. Ali, I.A. Khan*, S. Sharma, I. Ali, A. Kumar, A.F. Raja, K.A. Suri, B.D. Gupta,
N, Kumar, P. Dutt and G.N. Qazi. Hydroxychavicol: a natural molecule from Piper
betle against oral cavity pathogens. Poster presented at International Congress of
Environmental research organized by Birla Institute of Technology and Science Pilani
(Goa), 18-20 December, 2008.
(13) I. Ali, I.A. Khan*, F. Ali, T. Ismail, H.M. Sampat Kumar and G.N. Qazi.
Hydroximoyl chloride: a novel synthetic molecule against fungal pathogens. Poster
presented at International Congress of Environmental research organized by Birla
Institute of Technology and Science Pilani (Goa), 18-20 December, 2008.

(14) S. Sharma, M. Kuamr, A.B. Ram, N.P. Kalia, J. Suri, A. Khajuria, P. Suden, S. Bani,
P.S. Chauhan and I.A.Khan*. Immunomodulatory activity of piperine leading to
enhanced protective efficacy of rifampicin against Mycobacterium tuberculosis
infection. Poster presented at International symposium on TB diagnostic: Innovating
to make an impact, ICGEB, December 16-17, 2010.
* Corresponding author
Publications (published):
1. Mirza ZM, Kumar A, Kalia NP, Zargar A, Khan IA* (2011) Piperine as an inhibitor
of MdeA efflux pump of Staphylococcus aureus. Journal of Medical Microbiology
(In press)
2. Ali F, Sangwan PL, Koul S, Pandey A, Bani S, Abdullah ST, Sharma PR, Kitchlu S
and Khan IA* (2011) 4-epi-Pimaric acid: A phytomolecule as a potent antibacterial
and anti–biofilm agent for oral cavity pathogens European Journal of Clinical
Microbiology and Infectious Diseases. (DOI 10.1007/s10096-011-1287-x)
3. Ali I, Sharma P, Suri KA, Satti NK, Dutt P, Afrin F and Khan IA*(2011) In vitro
antifungal activities of amphotericin B in combination with acteoside, a
phenylethanoid glycoside from Colebrookea oppositifolia. Journal of Medical
Microbiology 60: 1326-1336.
4. Kamal A, Rajesh V.C, Shetti R.N.C, Azeeza S, Swapna P, Naseer M, Khan I.A,
Sharma S and Abdullah S.T. (2011) Anti-tubercular Agents. Part 6: Synthesis and
antimycobacterial activity of novel arylsulfonamido conjugated oxazolidilones
European Journal of Medicinal Chemistry 46: 893-900
5. Kumar M., Khan F.G., Sharma S., Kumar R., Faujdar J., Sharma R., Chauhan D.S.,
Singh R., Magotra S.K. and Khan I.A* (2010) Identification of Mycobacterium
tuberculosis genes uniquely expressed in tuberculosis patients. Microbial
pathogensis 50: 31-38
6. Thota N., Reddy M.V., Kumar A., Khan I.A. Sangwan P.L., Kalia N.P., Koul J.L.,
and Koul S. (2010) Substituted dihydronaphthalenes as efflux pump inhibitors of
Staphylococcus aureus. European Journal of Medicinal Chemistry 45(9): 3607-3616.
7. Reddy M.V., Thota N., Sangwan P.L., Malhotra P., Ali F., Khan I.A., Chimni S.S.
and Koul S. (2010) Novel bisstyryl derivatives of bakuchiol: Targeting oral cavity
pathogens. European Journal of Medicinal Chemistry 45(7): 3125-3134.

8. Kamal A, Rajesh V.C, Shetti R.N.C, Azeeza S, Ahmed S.K, Swapna P, Reddy A.M,
Khan I.A, Sharma S and Abdullah S.T. (2010) Anti-tubercular Agents. Part 5:
Synthesis and Biological Evaluation of Benzothiadiazine 1,1-dioxide Based
Congeners European Journal of Medicinal Chemistry 45(10): 4545-4553
9. Naqvi T., Mahajan D., Sharma R.L., Khan I.A. and Kapoor K.K. (2010) Synthesis
and Biological Screening of 4-(3,3-Dimethylspiro{bicyclo[2.2.1]heptan-2,50isoxazoline-2}-30-yl)-2-aryl-2,3-dihydro-1H-1,5-benzodiazepines.
Journal of
Heterocyclic Chemistry (DOI 10.1002/jhet.194)
10. Sharma S, Kumar M, Sharma S, Nargotra A, Koul S and Khan I.A.* (2010) Piperine
as inhibitor of Rv1258c, a putative multidrug efflux pump of Mycobacterium
tuberculosis. Journal of Antimicrobial Chemotherapy 65: 1694-1701
11. Nargotra A., Sharma S., Koul J.L., Sangwan P.L., Khan I.A., Kumar A., Taneja S.C.,
Koul S. (2009) Quantitative Structure Activity Relationship (QSAR) of piperine
analogs for bacterial NorA efflux pump inhibitors. European Journal of Medicinal
Chemistry. 44: 4128-4135
12. Sharma S, I.A. Khan*, I. Ali, F.Ali, M. Kumar, A. Kumar, R.K. Johri, S.T.
Abdullah, S. Bani, A. Pandey, K.A. Suri, B.D. Gupta, N.K. Satti, P. Dutt and G.N.
Qazi (2009) Evaluation of hydroxychavicol for its antimicrobial, antioxidant and antiinflammatory
activity for its potential use as oral care agent. Antimicrobial Agents
and Chemotherapy 53(1): 216-222.
13. Nargotra A., Koul S., Sharma S., Khan I.A., Kumar A., Thota N., Koul J.L., Taneja
S.C., Qazi G.N. (2009) Quantitative structure activity relationship (QSAR) of aryl
alkenyl amides/imines for bacterial efflux pump inhibitors. European Journal of
Medicinal Chemistry 44: 229-238
14. Sangwan P.L., Koul J.L., Koul S., Reddy M.V., Thota N., Khan I.A., Kumar A.,
Kalia N.P., Qazi G.N. (2008) Piperine analogs as potent Staphylococcus aureus NorA
efflux pump inhibitors. Bioorganic Medicinal Chemistry 16: 9847-9857
15. Thota, N.; Koul, S.; Reddy, M. V.; Sangwan, P. L.; Khan, I. A.; Kumar, A.; Raja, A.
F.; Andotra, S. S.; Qazi, G. N. (2008) Citral derived amides as potent bacterial NorA
efflux pump inhibitors Bioorganic Medicinal Chemistry 16: 6535-6543.
16. Kumar A, Khan I.A*, Koul S, Koul J.L, Taneja S.C, Ali I, Ali F, Sharma S, Mirza
Z.M, Kumar M, Sangwan P.L, Gupta P, Thota N, Qazi G.N. (2008) Novel structural
analogues of piperine as inhibitors of NorA efflux pump of Staphylococccus aureus.
Journal of Antimicrobial Chemotherapy 61:1270–1276.

17. T Ismail, S Shafi, P.P. Singh, N.A. Qazi, S.D. Sawant, I. Ali, I.A. Khan, H.M.S.
Kumar, G.N. Qazi & M.S. Alam (2008) Biologically active hydroxymoyl chlorides as
antifungal agents. Indian Journal of Chemistry 47B: 740-747.
18. Kamal A, Ahmed S.K, Reddy K.S, Khan N.A, Rajesh V.C, Shetty N.C, Siddhardha
B, Murthy U.S.N, Khan I.A, Kumar M, Sharma S, Ram A.B.(2007) Anti-tubercular
agent. Part IV: Synthesis and antimycobacterial evaluation of nitroheterocyclic-based
1,2,4-benzothiadiazines Bioorganic Medicinal Chemistry Letters 17 : 5419-5422.
19. Khan I.A*., Z.M. Mirza, A. Kumar, V. Verma. and Q.N. Qazi. (2006) Piperine, A
Phytochemical Potentiator of Ciprofloxacin against Staphylococcus aureus.
Antimicrobial Agents Chemotherapy 50(2): 810-812
20. Manoj Kumar, I. A. Khan*, V. Verma, Narender. Kalyan and G. N. Qazi.(2005)
Rapid, Inexpensive MIC determination of Mycobacterium tuberculosis by using
Microplate Nitrate Reductase Assay. Diagnostic Microbiology and Infectious
Diseases 53: 121-124
21. Manoj-Kumar, I.A.Khan*, V.Verma and G.N. Qazi. (2005) Microplate nitrate
Reductase assay versus alamar blue assay for MIC Determination of Mycobacterium
tuberculosis. International Journal of Tubercle and Lung Diseases. 9(8): 939-941
22. Khan FG, Rattan A, Khan IA and Kalia A. (1998) Study of Pseudomonas aeruginosa
causing ventilator associated pneumonia. Indian Journal of Medical Research
107:68-74.
23. Khan F.G., Rattan A., Khan I.A. and Kalia A. (1996) Fingerprinting of Pseudomonas
aeruginosa: Comparison of pyocin typing and whole cell protein analysis by SDS-
PAGE: A preliminary study. Indian Journal of Medical Research 104: 342-348.
24. Khan I.A., Rattan A., Fatma T., Khan F.G. and Kalia A. (1996) Application of whole
cell protein analysis by SDS PAGE to establish the source of Salmonella typhimurium
Journal of Infection 33: 69-171.
25. Khan I.A., Rattan A., Fatma T., Khan F.G. and Kalia A. (1995) Fingerprinting of
Salmonella typhimurium: Comparison between traditional and molecular methods.
Indian Journal of Medical Microbiology 13(3): 141-144.
* Corresponding author