22.11.2018 Views

Systematic-Review-Drug-Efficiency-Dissertation-Sample-Work-Tutors-India

Idiopathic Pulmonary Fibrosis (IPF) as the name suggests is a progressive disorder with no known aetiology. It is characterised by the thickening of the alveoli due to scarring resulting in cough. It is known to primarily occur in older adults over 60 years of age. The findings of IPF have a known association of Usual Interstitial Pneumonia (UIP) (Raghu et al., 2011; Kawano-Dourado & Kairalla, 2013; Wells, 2013). It has been deemed that the prognosis is generally poor when UIP has been confirmed (King et al., 2001b). The median survival rate of IPF is 50%, typically around two years after diagnosis (Raghu et al., 2011; King et al., 2001b).

Idiopathic Pulmonary Fibrosis (IPF) as the name suggests is a progressive disorder with no known aetiology. It is characterised by the thickening of the alveoli due to scarring resulting in cough. It is known to primarily occur in older adults over 60 years of age. The findings of IPF have a known association of Usual Interstitial Pneumonia (UIP) (Raghu et al., 2011; Kawano-Dourado & Kairalla, 2013; Wells, 2013). It has been deemed that the prognosis is generally poor when UIP has been confirmed (King et al., 2001b). The median survival rate of IPF is 50%, typically around two years after diagnosis (Raghu et al., 2011; King et al., 2001b).

SHOW MORE
SHOW LESS

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

http://www.ncbi.nlm.nih.gov/pubmed/16244516.<br />

Reas, H.W. (1963). The effect of N-acetylcysteine on the viscosity of tracheobronchial<br />

secretions in cystic fibrosis of the pancreas. The Journal of pediatrics. [Online]. 62. pp.<br />

31–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/13973420.<br />

Renzoni, E., Lympany, P., Sestini, P., Pantelidis, P., Wells, A., Black, C., Welsh, K., Bunn,<br />

C., Knight, C., Foley, P. & Du Bois, R.M. (2000). Distribution of novel polymorphisms<br />

of the interleukin-8 and CXC receptor 1 and 2 genes in systemic sclerosis and<br />

cryptogenic fibrosing alveolitis. Arthritis & Rheumatism. [Online]. 43 (7). pp. 1633–<br />

1640. Available from: http://doi.wiley.com/10.1002/1529-<br />

0131%28200007%2943%3A7%3C1633%3A%3AAID-ANR29%3E3.0.CO%3B2-9.<br />

Richeldi, L., du Bois, R.M., Raghu, G., Azuma, A., Brown, K.K., Costabel, U., Cottin, V.,<br />

Flaherty, K.R., Hansell, D.M., Inoue, Y., Kim, D.S., Kolb, M., Nicholson, A.G., Noble,<br />

P.W., Selman, M., Taniguchi, H., Brun, M., Le Maulf, F., Girard, M., Stowasser, S.,<br />

Schlenker-Herceg, R., Disse, B., Collard, H.R. & INPULSIS Trial Investigators (2014).<br />

Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. The New England<br />

journal of medicine. [Online]. 370 (22). pp. 2071–82. Available from:<br />

http://www.ncbi.nlm.nih.gov/pubmed/24836310.<br />

Richter, A., Puddicombe, S.M., Lordan, J.L., Bucchieri, F., Wilson, S.J., Djukanovic, R.,<br />

Dent, G., Holgate, S.T. & Davies, D.E. (2001). The contribution of interleukin (IL)-4<br />

and IL-13 to the epithelial-mesenchymal trophic unit in asthma. American journal of<br />

respiratory cell and molecular biology. 25 (3). pp. 385–391.<br />

Riha, R.L., Yang, I.A., Rabnott, G.C., Tunnicliffe, A.M., Fong, K.M. & Zimmerman, P. V.<br />

(2004). Cytokine gene polymorphisms in idiopathic pulmonary fibrosis. Internal<br />

Medicine Journal. [Online]. 34 (3). pp. 126–129. Available from:<br />

http://doi.wiley.com/10.1111/j.1444-0903.2004.00503.x.<br />

Rindone, E. & Rosset, L. (2014). The Point on N-acetylcysteine in Idiopathic Pulmonary<br />

Fibrosis Treatment. Journal of Palliative Care & Medicine. [Online]. 4 (5). pp. 1–2.<br />

Available from: http://www.omicsgroup.org/journals/the-point-on-nacetylcysteine-inidiopathic-pulmonary-fibrosis-treatment-2165-7386.1000193.php?aid=32712.<br />

© 2017-2018 All Rights Reserved, No part of this document should be modified/used without prior consent<br />

<strong>Tutors</strong> <strong>India</strong> - Your trusted mentor since 2001<br />

www.tutorindia.com I UK # +44-1143520021, info@tutorsindia.com<br />

Page 156 of 172

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!