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Idiopathic Pulmonary Fibrosis (IPF) as the name suggests is a progressive disorder with no known aetiology. It is characterised by the thickening of the alveoli due to scarring resulting in cough. It is known to primarily occur in older adults over 60 years of age. The findings of IPF have a known association of Usual Interstitial Pneumonia (UIP) (Raghu et al., 2011; Kawano-Dourado & Kairalla, 2013; Wells, 2013). It has been deemed that the prognosis is generally poor when UIP has been confirmed (King et al., 2001b). The median survival rate of IPF is 50%, typically around two years after diagnosis (Raghu et al., 2011; King et al., 2001b).
Idiopathic Pulmonary Fibrosis (IPF) as the name suggests is a progressive disorder with no known aetiology. It is characterised by the thickening of the alveoli due to scarring resulting in cough. It is known to primarily occur in older adults over 60 years of age. The findings of IPF have a known association of Usual Interstitial Pneumonia (UIP) (Raghu et al., 2011; Kawano-Dourado & Kairalla, 2013; Wells, 2013). It has been deemed that the prognosis is generally poor when UIP has been confirmed (King et al., 2001b). The median survival rate of IPF is 50%, typically around two years after diagnosis (Raghu et al., 2011; King et al., 2001b).
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Nishimura, J. & Inoue, T. (2009). Assessment of prognosis of patients with idiopathic<br />
pulmonary fibrosis by computer-aided analysis of CT images. Journal of thoracic<br />
imaging. [Online]. 24 (3). pp. 216–22. Available from:<br />
http://www.ncbi.nlm.nih.gov/pubmed/19704326.<br />
Iyer, S.N., Gurujeyalakshmi, G. & Giri, S.N. (1999a). Effects of pirfenidone on procollagen<br />
gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis.<br />
The Journal of pharmacology and experimental therapeutics. [Online]. 289 (1). pp.<br />
211–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10087006.<br />
Iyer, S.N., Gurujeyalakshmi, G. & Giri, S.N. (1999b). Effects of pirfenidone on transforming<br />
growth factor-beta gene expression at the transcriptional level in bleomycin hamster<br />
model of lung fibrosis. The Journal of pharmacology and experimental therapeutics.<br />
[Online]. 291 (1). pp. 367–73. Available from:<br />
http://www.ncbi.nlm.nih.gov/pubmed/10490926.<br />
Iyer, S.N., Hyde, D.M. & Giri, S.N. (2000). Anti-Inflammatory Effect of Pirfenidone in the<br />
Bleomycin-Hamster Model of Lung Inflammation. Inflammation. [Online]. 24 (5). pp.<br />
477–491. Available from: http://link.springer.com/10.1023/A:1007068313370.<br />
Iyer, S.N., Margolin, S.B., Hyde, D.M. & Giri, S.N. (1998). Lung fibrosis is ameliorated by<br />
pirfenidone fed in diet after the second dose in a three-dose bleomycin-hamster model.<br />
Experimental lung research. [Online]. 24 (1). pp. 119–32. Available from:<br />
http://www.ncbi.nlm.nih.gov/pubmed/9457473.<br />
Iyer, S.N., Wild, J.S., Schiedt, M.J., Hyde, D.M., Margolin, S.B. & Giri, S.N. (1995). Dietary<br />
intake of pirfenidone ameliorates bleomycin-induced lung fibrosis in hamsters. The<br />
Journal of laboratory and clinical medicine. [Online]. 125 (6). pp. 779–85. Available<br />
from: http://www.ncbi.nlm.nih.gov/pubmed/7539478.<br />
Izbicki, G. & Breuer, R. (2003). IL-4 is not a key profibrotic cytokine in bleomycin-induced<br />
lung fibrosis model. Journal of immunology (Baltimore, Md. : 1950). 171 (6). pp. 2767–<br />
2768.<br />
Izumi, S., Iikura, M. & Hirano, S. (2012). Prednisone, azathioprine, and N-acetylcysteine for<br />
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