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Idiopathic Pulmonary Fibrosis (IPF) as the name suggests is a progressive disorder with no known aetiology. It is characterised by the thickening of the alveoli due to scarring resulting in cough. It is known to primarily occur in older adults over 60 years of age. The findings of IPF have a known association of Usual Interstitial Pneumonia (UIP) (Raghu et al., 2011; Kawano-Dourado & Kairalla, 2013; Wells, 2013). It has been deemed that the prognosis is generally poor when UIP has been confirmed (King et al., 2001b). The median survival rate of IPF is 50%, typically around two years after diagnosis (Raghu et al., 2011; King et al., 2001b).

Idiopathic Pulmonary Fibrosis (IPF) as the name suggests is a progressive disorder with no known aetiology. It is characterised by the thickening of the alveoli due to scarring resulting in cough. It is known to primarily occur in older adults over 60 years of age. The findings of IPF have a known association of Usual Interstitial Pneumonia (UIP) (Raghu et al., 2011; Kawano-Dourado & Kairalla, 2013; Wells, 2013). It has been deemed that the prognosis is generally poor when UIP has been confirmed (King et al., 2001b). The median survival rate of IPF is 50%, typically around two years after diagnosis (Raghu et al., 2011; King et al., 2001b).

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Increasing Global Mortality from Idiopathic Pulmonary Fibrosis in the Twenty-First<br />

Century. Annals of the American Thoracic Society. [Online]. 11 (8). pp. 1176–1185.<br />

Available from: http://www.atsjournals.org/doi/abs/10.1513/AnnalsATS.201404-145OC.<br />

Hutyrová, B., Pantelidis, P., Drábek, J., Zůrková, M., Kolek, V., Lenhart, K., Welsh, K.I., Du<br />

Bois, R.M. & Petrek, M. (2002a). Interleukin-1 gene cluster polymorphisms in<br />

sarcoidosis and idiopathic pulmonary fibrosis. American journal of respiratory and<br />

critical care medicine. 165 (2). pp. 148–151.<br />

Hutyrová, B., Pantelidis, P., Drábek, J., Žůrková, M., Kolek, V., Lenhart, K., Welsh, K.I., Du<br />

Bois, R.M. & Petřek, M. (2002b). Interleukin-1 Gene Cluster Polymorphisms in<br />

Sarcoidosis and Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and<br />

Critical Care Medicine. [Online]. 165 (2). pp. 148–151. Available from:<br />

http://www.atsjournals.org/doi/abs/10.1164/ajrccm.165.2.2106004.<br />

Hyldgaard, C., Hilberg, O., Muller, A. & Bendstrup, E. (2014). A cohort study of interstitial<br />

lung diseases in central Denmark. Respiratory Medicine. [Online]. 108 (5). pp. 793–799.<br />

Available from: http://linkinghub.elsevier.com/retrieve/pii/S0954611113003673.<br />

Iida, K., Kadota, J., Kawakami, K., Matsubara, Y., Shirai, R. & Kohno, S. (1997). Analysis<br />

of T cell subsets and beta chemokines in patients with pulmonary sarcoidosis. Thorax.<br />

52 (5). pp. 431–437.<br />

Ingram, J.L., Rice, A.B., Geisenhoffer, K., Madtes, D.K. & Bonner, J.C. (2004). IL-13 and<br />

IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-<br />

AA and PDGF-Ralpha. FASEB journal : official publication of the Federation of<br />

American Societies for Experimental Biology. 18 (10). pp. 1132–1134.<br />

Inomata, M., Kamio, K., Azuma, A., Matsuda, K., Kokuho, N., Miura, Y., Hayashi, H., Nei,<br />

T., Fujita, K., Saito, Y. & Gemma, A. (2014). Pirfenidone inhibits fibrocyte<br />

accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis. Respiratory<br />

Research. [Online]. 15 (1). pp. 16. Available from: http://respiratoryresearch.com/content/15/1/16.<br />

Iwasawa, T., Asakura, A., Sakai, F., Kanauchi, T., Gotoh, T., Ogura, T., Yazawa, T.,<br />

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