22.11.2018 Views

Systematic-Review-Drug-Efficiency-Dissertation-Sample-Work-Tutors-India

Idiopathic Pulmonary Fibrosis (IPF) as the name suggests is a progressive disorder with no known aetiology. It is characterised by the thickening of the alveoli due to scarring resulting in cough. It is known to primarily occur in older adults over 60 years of age. The findings of IPF have a known association of Usual Interstitial Pneumonia (UIP) (Raghu et al., 2011; Kawano-Dourado & Kairalla, 2013; Wells, 2013). It has been deemed that the prognosis is generally poor when UIP has been confirmed (King et al., 2001b). The median survival rate of IPF is 50%, typically around two years after diagnosis (Raghu et al., 2011; King et al., 2001b).

Idiopathic Pulmonary Fibrosis (IPF) as the name suggests is a progressive disorder with no known aetiology. It is characterised by the thickening of the alveoli due to scarring resulting in cough. It is known to primarily occur in older adults over 60 years of age. The findings of IPF have a known association of Usual Interstitial Pneumonia (UIP) (Raghu et al., 2011; Kawano-Dourado & Kairalla, 2013; Wells, 2013). It has been deemed that the prognosis is generally poor when UIP has been confirmed (King et al., 2001b). The median survival rate of IPF is 50%, typically around two years after diagnosis (Raghu et al., 2011; King et al., 2001b).

SHOW MORE
SHOW LESS

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

Flaherty, K.R., Andrei, A.-C., Murray, S., Fraley, C., Colby, T. V, Travis, W.D., Lama, V.,<br />

Kazerooni, E.A., Gross, B.H., Toews, G.B. & Martinez, F.J. (2006). Idiopathic<br />

pulmonary fibrosis: prognostic value of changes in physiology and six-minute-walk test.<br />

American journal of respiratory and critical care medicine. [Online]. 174 (7). pp. 803–9.<br />

Available from: http://www.ncbi.nlm.nih.gov/pubmed/16825656.<br />

Flaherty, K.R., Colby, T. V, Travis, W.D., Toews, G.B., Mumford, J., Murray, S., Thannickal,<br />

V.J., Kazerooni, E.A., Gross, B.H., Lynch, J.P. & Martinez, F.J. (2003a). Fibroblastic<br />

foci in usual interstitial pneumonia: idiopathic versus collagen vascular disease.<br />

American journal of respiratory and critical care medicine. 167 (10). pp. 1410–1415.<br />

Flaherty, K.R., Thwaite, E.L., Kazerooni, E.A., Gross, B.H., Toews, G.B., Colby, T. V,<br />

Travis, W.D., Mumford, J.A., Murray, S., Flint, A., Lynch, J.P. & Martinez, F.J. (2003b).<br />

Radiological versus histological diagnosis in UIP and NSIP: survival implications.<br />

Thorax. [Online]. 58 (2). pp. 143–8. Available from:<br />

http://www.ncbi.nlm.nih.gov/pubmed/12554898.<br />

Flaherty, K.R., Toews, G.B., Travis, W.D., Colby, T. V, Kazerooni, E.A., Gross, B.H., Jain,<br />

A., Strawderman, R.L., Paine, R., Flint, A., Lynch, J.P. & Martinez, F.J. (2002). Clinical<br />

significance of histological classification of idiopathic interstitial pneumonia. The<br />

European respiratory journal. [Online]. 19 (2). pp. 275–83. Available from:<br />

http://www.ncbi.nlm.nih.gov/pubmed/11866008.<br />

Flaherty, K.R., Travis, W.D., Colby, T. V, Toews, G.B., Kazerooni, E.A., Gross, B.H., Jain,<br />

A., Strawderman, R.L., Flint, A., Lynch, J.P. & Martinez, F.J. (2001). Histopathologic<br />

variability in usual and nonspecific interstitial pneumonias. American journal of<br />

respiratory and critical care medicine. [Online]. 164 (9). pp. 1722–7. Available from:<br />

http://www.ncbi.nlm.nih.gov/pubmed/11719316.<br />

Flood-Page, P., Menzies-Gow, A., Phipps, S., Ying, S., Wangoo, A., Ludwig, M.S., Barnes,<br />

N., Robinson, D. & Kay, A.B. (2003a). Anti-IL-5 treatment reduces deposition of ECM<br />

proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics.<br />

The Journal of clinical investigation. 112 (7). pp. 1029–1036.<br />

Flood-Page, P.T., Menzies-Gow, A.N., Kay, A.B. & Robinson, D.S. (2003b). Eosinophil’s<br />

© 2017-2018 All Rights Reserved, No part of this document should be modified/used without prior consent<br />

<strong>Tutors</strong> <strong>India</strong> - Your trusted mentor since 2001<br />

www.tutorindia.com I UK # +44-1143520021, info@tutorsindia.com<br />

Page 125 of 172

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!