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Idiopathic Pulmonary Fibrosis (IPF) as the name suggests is a progressive disorder with no known aetiology. It is characterised by the thickening of the alveoli due to scarring resulting in cough. It is known to primarily occur in older adults over 60 years of age. The findings of IPF have a known association of Usual Interstitial Pneumonia (UIP) (Raghu et al., 2011; Kawano-Dourado & Kairalla, 2013; Wells, 2013). It has been deemed that the prognosis is generally poor when UIP has been confirmed (King et al., 2001b). The median survival rate of IPF is 50%, typically around two years after diagnosis (Raghu et al., 2011; King et al., 2001b).
Idiopathic Pulmonary Fibrosis (IPF) as the name suggests is a progressive disorder with no known aetiology. It is characterised by the thickening of the alveoli due to scarring resulting in cough. It is known to primarily occur in older adults over 60 years of age. The findings of IPF have a known association of Usual Interstitial Pneumonia (UIP) (Raghu et al., 2011; Kawano-Dourado & Kairalla, 2013; Wells, 2013). It has been deemed that the prognosis is generally poor when UIP has been confirmed (King et al., 2001b). The median survival rate of IPF is 50%, typically around two years after diagnosis (Raghu et al., 2011; King et al., 2001b).
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espectively. However, one study by Behr et al 36 attempted to cover the efficacy of the<br />
combined drug treatment in eight nations which include Austria, Belgium, Denmark, France,<br />
Germany, Italy, Sweden, and the UK. The inclusion of these studies was based on crucial<br />
examination of the inclusion and exclusion criteria set wherein the PRISMA guidelines and<br />
flowchart are used. The CASP tool is then used for the assessment of the RCTs considered in<br />
the present research wherein all the studies are of moderate to good quality and hence the<br />
studies are reliable to be utilised for the systematic review. All studies considered for the<br />
research are RCTs wherein they all fall under the period of 2015-2016. Almost all studies<br />
revealed adverse effects with respect to the administration of combined therapy; however<br />
there were reduction in the PFS and FVC in the intervention group.<br />
36 https://www.ncbi.nlm.nih.gov/pubmed/27161257<br />
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