Program & Abstract Book - EPFL Latsis Symposium 2009

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EPFL Latsis Symposium 2009: Understanding Violence 58 P-4 February 11-13 2009 as s o c i a t i o n b e t w e e n e X p e r i e n c e o f a g g r e s s i o n a n D a n X i e t y in m a l e m i c e : ef f e c t s o f D i a z e p a m a n D b u s p i r o n e Bondar, Natalia 1 ; Kudryavtseva, Natalia 1 1 Neurogenetics of Social Behavior Sector, Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia The sensory contact technique increases aggressiveness in male mice and allows an aggressive type of behavior to be formed as a result of repeated experience of social victories in daily agonistic interactions. In the low aggressive and high emotion mice of CBA/Lac strain, repeated positive fighting experience leads to increased plus maze anxiety in the winners after 10 days of aggression experience and much more after 20 days. Aggressive motivation in the winners was significantly increased as revealed by parameters of partition test measuring behavioral reactivity to other conspecifics. Thus, anxiety as a consequence of repeated experience of aggression associates with the increase of aggressive motivation in CBA/Lac mice. Repeated experience of aggression is accompanied by the increase of anxiety and decrease of aggressive motivation in 20 days-winners of high aggressive C57BL/6J strain. It was concluded, that 1. Repeated experience of aggression provokes the development of anxiety in male mice. 2. The level of anxiety as well as it’s behavioral realization depends on the duration of aggressive experience and genetic strain. Anxiolytics buspirone (1 mg/kg, i.p) and diazepam (0.5 mg/kg, i.p) induced anxiogenic effect and reduced aggression in the winners with 3 days experience of aggression. No significant effects of buspirone on aggressive and anxious behaviors were found in mice with 20 days experience of aggression. In this group of winners diazepam produced anxiolytic and antiaggressive effects. Opioid receptor antagonist naltrexone (1 mg/ kg, i.p.) also had different effects in the winners with long and short experience of aggression. It was hypothesized that previous aggression experience modified animal sensitivity to drug treatment. This work was supported by grant No. 07-04-00014 from the Russian Foundation for Basic Research and grant MK-2109.2007.4 from Russian Federation President in support of young scientists.
EPFL Latsis Symposium 2009: Understanding Violence P-5 Poster Abstracts tr a n s D u c e r o f r e g u l a t e D creb a c t i v i t y 1 (torc1) : a r o l e in r e w a r D-r e l a t e D l e a r n i n g a n D m e m o r y a n D b e h a v i o r a l r e s p o n s e s t o e m o t i o n a l s t i m u l i ? Breuillaud, Lionel1 ; Pierre J., Magistretti,1 Olivier, Halfon2 ; 1 2 Jean-René, Cardinaux 1 Center for Psychiatric Neuroscience; 2 Service of Child and Ado- lescent Psychiatry The transcription factor cAMP-responsive element binding protein (CREB) has been shown to be essential for the generation of long lasting forms of synaptic plasticity that are associated with learning and memory and the gating of emotional responses in the CNS. TORC1 is a newly discovered CREB coactivator that strongly enhances its transcriptional activity. We have shown that TORC1 functions as a calcium- and cAMP-sensitive coincidence detector in neurons and that it is involved in the maintenance of late-phase long-term-potentiation (L-LTP) in the rat hippocampus (Kovács et al., 2007. PNAS 104, 4700-4705). Given the importance of synaptic integration of dopamine- and glutamate-mediated signals in rewardrelated learning and memory mechanisms, we decided to study the role of TORC1 in this context. To this end we have produced a mouse with a deficient Torc1 gene using a gene trap approach. We have obtained viable heterozygous and TORC1-null mice that we are currently phenotyping. We are focusing on a putative alteration in the acquisition of cocaine addiction (cocaine-conditioned place preference and cocaine self-administration paradigms) and a general characterization of their behavior (memory, depression and anxiety). The study of this mouse line could make a contribution to the understanding of the molecular basis of neuropsychiatric conditions. 59
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